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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification [作者：Davies, AH; Barrett, I; Pambid, MR; Hu, K; Stratford, AL; Freeman, S; Berquin, IM; Pelech, S; Hieter, P; Maxwell, C; Dunn, SE,期刊：Oncogene, 页码：3649-3660 , 文章类型： Article，,卷期：2011年30-34] Y-box binding protein-1 (YB-1) expression in the mammary gland promotes breast carcinoma that demonstrates a high degree of genomic instability. In the present study, we developed a model of pre-malignancy to characteriz... The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral [作者：Osei-Sarfo, K; Martello, L; Ibrahim, S; Pellicer, A,期刊：Oncogene, 页码：3661-3671 , 文章类型： Article，,卷期：2011年30-34] The Ras superfamily of GTPases is involved in the modification of many cellular processes including cellular motility, proliferation and differentiation. Our laboratory has previously identified the RalGDS-related (Rgr) ... Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers [作者：Gibert, B; Hadchity, E; Czekalla, A; Aloy, MT; Colas, P; Rodriguez-Lafrasse, C; Arrigo, AP; Diaz-Latoud, C,期刊：Oncogene, 页码：3672-3681 , 文章类型： Article，,卷期：2011年30-34] Human heat shock protein 27 (Hsp27, HspB1) is an antiapoptotic protein characterized for its tumorigenic and metastatic properties, and now referenced as a major therapeutic target in many types of cancer. Hsp27 biochemi... SCUBE3 is an endogenous TGF-beta receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer [作者：Wu, YY; Peck, K; Chang, YL; Pan, SH; Cheng, YF; Lin, JC; Yang, RB; Hong, TM; Yang, PC,期刊：Oncogene, 页码：3682-3693 , 文章类型： Article，,卷期：2011年30-34] Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is a secreted glycoprotein that is overexpressed in lung cancer tumor tissues and is correlated with the invasive ability in a lung cancer cell line model.... beta-Catenin is required for Ron receptor-induced mammary tumorigenesis [作者：Wagh, PK; Gray, JK; Zinser, GM; Vasiliauskas, J; James, L; Monga, SP; Waltz, SE,期刊：Oncogene, 页码：3694-3704 , 文章类型： Article，,卷期：2011年30-34] Our previous studies demonstrated that selective overexpression of the Ron receptor tyrosine kinase in the murine mammary epithelium leads to mammary tumor formation. Biochemical analysis of mammary tumor lysates showed ... Mutant K-Ras increases GSK-3 beta gene expression via an ETS-p300 transcriptional complex in pancreatic cancer [作者：Zhang, JS; Koenig, A; Harrison, A; Ugolkov, AV; Fernandez-Zapico, ME; Couch, FJ; Billadeau, DD,期刊：Oncogene, 页码：3705-3715 , 文章类型： Article，,卷期：2011年30-34] Glycogen synthase kinase-3 beta (GSK-3 beta) is overexpressed in a number of human malignancies and has been shown to contribute to tumor cell proliferation and survival. Although regulation of GSK-3 beta activity has be... Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress [作者：Dong, L; Jiang, CC; Thorne, RF; Croft, A; Yang, F; Liu, H; de Bock, CE; Hersey, P; Zhang, XD,期刊：Oncogene, 页码：3716-3726 , 文章类型： Article，,卷期：2011年30-34] Past studies have shown that upregulation of the antiapoptotic Bcl-2 family protein Mcl-1 is a major adaptive mechanism of melanoma cells to endoplasmic reticulum (ER) stress, and has an important role in resistance of t... New model systems provide insights into Myc-induced transformation [作者：Wasylishen, AR; Stojanova, A; Oliveri, S; Rust, AC; Schimmer, AD; Penn, LZ,期刊：Oncogene, 页码：3727-3734 , 文章类型： Article，,卷期：2011年30-34] The ability of Myc to promote cellular transformation is well established; however, a better understanding of the mechanisms through which Myc mediates tumorigenesis is essential for the development of therapeutic approa...