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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation [作者：Sriram, G; Reichman, C; Tunceroglu, A; Kaushal, N; Saleh, T; Machida, K; Mayer, B; Ge, Q; Li, J; Hornbeck, P; Kalodimos, CG; Birge, RB,期刊：Oncogene, 页码：4645-4655 , 文章类型： Article，,卷期：2011年30-46] Here, we report the identification and characterization of a novel tyrosine phosphorylation site in the carboxyterminal Src Homology 3 (SH3) (SH3C) domain of the Crk adaptor protein. Y251 is located in the highly conserv... TP63 P2 promoter functional analysis identifies beta-catenin as a key regulator of Delta Np63 expression [作者：Ruptier, C; De Gasperis, A; Ansieau, S; Granjon, A; Taniere, P; Lafosse, I; Shi, H; Petitjean, A; Taranchon-Clermont, E; Tribollet, V; Voeltzel, T; Scoazec, JY; Maguer-Satta, V; Puisieux, A; Hainaut, P; Cavard, C; de Fromentel, CC,期刊：Oncogene, 页码：4656-4665 , 文章类型： Article，,卷期：2011年30-46] The Delta Np63 protein, a product of the TP63 gene that lacks the N-terminal domain, has a critical role in the maintenance of self renewal and progenitor capacity in several types of epithelial tissues. Delta Np63 is fr... Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma [作者：Watt, SA; Pourreyron, C; Purdie, K; Hogan, C; Cole, CL; Foster, N; Pratt, N; Bourdon, JC; Appleyard, V; Murray, K; Thompson, AM; Mao, X; Mein, C; Bruckner-Tuderman, L; Evans, A; McGrath, JA; Proby, CM; Foerster, J; Leigh, IM; South, AP,期刊：Oncogene, 页码：4666-4677 , 文章类型： Article，,卷期：2011年30-46] Identifying therapeutic targets for cancer treatment relies on consistent changes within particular types or sub-types of malignancy. The ability to define either consistent changes or sub-types of malignancy is often ma... Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3 [作者：Aziz, MH; Shen, H; Maki, CG,期刊：Oncogene, 页码：4678-4686 , 文章类型： Article，,卷期：2011年30-46] Wild-type p53 is a stress-responsive tumor suppressor and potent growth inhibitor. Genotoxic stresses (for example, ionizing and ultraviolet radiation or chemotherapeutic drug treatment) can activate p53, but also induce... Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: distinct, overlapping or same populations [作者：Floor, S; van Staveren, WCG; Larsimont, D; Dumont, JE; Maenhaut, C,期刊：Oncogene, 页码：4609-4621 , 文章类型： Review，,卷期：2011年30-46] Cell populations of solid cancers and their distant models, the cancer cell lines, have been categorized in sub-populations: cancer stem-tumor-propagating cells (CSC-TPC) versus derived cells, epithelial-versus mesenchym... Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression [作者：Lushnikova, T; Bouska, A; Odvody, J; Dupont, WD; Eischen, CM,期刊：Oncogene, 页码：4622-4631 , 文章类型： Article，,卷期：2011年30-46] Aging is thought to negatively affect multiple cellular processes including the ability to maintain chromosome stability. Chromosome instability (CIN) is a common property of cancer cells and may be a contributing factor... Evidence for the transmission of neoplastic properties from transformed to normal human stem cells [作者：Werbowetski-Ogilvie, TE; Schnerch, A; Rampalli, S; Mills, CE; Lee, JB; Hong, SH; Levadoux-Martin, M; Bhatia, M,期刊：Oncogene, 页码：4632-4644 , 文章类型： Article，,卷期：2011年30-46] The in vivo relationship between human tumor cells and interacting normal cells in their local environment is poorly understood. Here, using a uniquely developed in vitro co-culture system for human embryonic stem cells ...