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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Structure Determination and Interception of Biosynthetic Intermediates for the Plantazolicin Class of Highly Discriminating Antibiotics [作者：MOLOHON KATIE J; MELBY JOEL O; LEE JAEHEON; EVANS BRADLEY S; DUNBAR KYLE L; BUMPUS STEFANIE B; KELLEHER NEIL L; MITCHELL DOUGLAS A,期刊：ACS CHEMICAL BIOLOGY, 页码：1307-1313 , 文章类型： Article，,卷期：2011年6-12] The soil-dwelling, plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42 is a prolific producer of complex natural products. Recently, a new FZB42 metabolite, plantazolicin (PZN), has been described as a memb... A Map of Minor Groove Shape and Electrostatic Potential from Hydroxyl Radical Cleavage Patterns of DNA [作者：BISHOP ERIC P; ROHS REMO; PARKER STEPHEN C J; WEST SEAN M; LIU PENG; MANN RICHARD S; HONIG BARRY; TULLIUS THOMAS D,期刊：ACS CHEMICAL BIOLOGY, 页码：1314-1320 , 文章类型： Article，,卷期：2011年6-12] DNA shape variation and the associated variation in minor groove electrostatic, potential are widely exploited by proteins for DNA recognition. Here we show that the hydroxyl radical cleavage pattern is a quantitative me... Caught in the Act: Covalent Cross-Linking Captures Activator-Coactivator Interactions in Vivo [作者：KRISHNAMURTHY MALATHY; DUGAN AMANDA; NWOKOYE ADAORA; FUNG YIKHONG; LANCIA JODY K; MAJMUDAR CHINMAY Y; MAPP ANNA K,期刊：ACS CHEMICAL BIOLOGY, 页码：1321-1326 , 文章类型： Article，,卷期：2011年6-12] Currently there are few methods suitable for the discovery and characterization of transient, moderate affinity protein-protein interactions in their native environment, despite their prominent role in a host of cellular... Immune Interference in Mycobacterium tuberculosis Intracellular Iron Acquisition through Siderocalin Recognition of Carboxymycobactins [作者：HOETTE TRISHA M; CLIFTON MATTHEW C; ZAWADZKA ANNA M; HOLMES MEG A; STRONG ROLAND K; RAYMOND KENNETH N,期刊：ACS CHEMICAL BIOLOGY, 页码：1327-1331 , 文章类型： Article，,卷期：2011年6-12] The innate immune system antibacterial protein Siderocalin (Scn) binds ferric carboxymycobactin (CMB) and also several catecholate siderophores. Although the recognition of catecholates by Scn has been thoroughly investi... Temporal and Spatial Regulation of MicroRNA Activity with Photoactivatable Cantimirs [作者：ZHENG GENHUA; COCHELLA LUISA; LIU JIE; HOBERT OLIVER; LI WENHONG,期刊：ACS CHEMICAL BIOLOGY, 页码：1332-1338 , 文章类型： Article，,卷期：2011年6-12] MicroRNAs (miRNAs) are small non-coding RNAs that play numerous important roles in physiology and human diseases. During animal development, many miRNAs are expressed continuously from early embryos throughout adults, ye... Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies [作者：DAY JAMES E H; SHARP SWEE Y; ROWLANDS MARTIN G; AHERNE WYNNE; HAYES ANGELA; RAYNAUD FLORENCE I; LEWIS WILLIAM; ROE S MARK; PRODROMOU CHRISOSTOMOS; PEARL LAURENCE H; WORKMAN PAUL; MOODY CHRISTOPHER J,期刊：ACS CHEMICAL BIOLOGY, 页码：1339-1347 , 文章类型： Article，,卷期：2011年6-12] A series of resorcylic acid macrolactams, nitrogen analogues of the naturally occurring macrolactone radicicol, have been prepared by chemical synthesis and evaluated as inhibitors of heat shock protein 90 (Hsp90), an em... Attenuation of Virulence in Pathogenic Bacteria Using Synthetic Quorum-Sensing Modulators under Native Conditions on Plant Hosts [作者：PALMER ANDREW G; STRENG EVAN; BLACKWELL HELEN E,期刊：ACS CHEMICAL BIOLOGY, 页码：1348-1356 , 文章类型： Article，,卷期：2011年6-12] Quorum sensing (QS) is often critical in both pathogenic and mutualistic relationships between bacteria and their eukaryotic hosts. Gram-negative bacteria typically use N-acylated L-homoserine lactone (AHL) signals for Q... Macrocycles That Inhibit the Binding between Heat Shock Protein 90 and TPR-Containing Proteins [作者：ARDI VERONICA C; ALEXANDER LESLIE D; JOHNSON VICTORIA A; MCALPINE SHELLI R,期刊：ACS CHEMICAL BIOLOGY, 页码：1357-1366 , 文章类型： Article，,卷期：2011年6-12] Heat shock protein 90 (Hsp90) accounts for 1-2% of the total proteins in normal cells and functions as a molecular chaperone that folds, assembles, and stabilizes client proteins. Hsp90 is over-expressed (3- to 6-fold in... Protein Side-Chain Translocation Mutagenesis via Incorporation of Peptoid Residues [作者：LEE BYOUNGCHUL; ZUCKERMANN RONALD N,期刊：ACS CHEMICAL BIOLOGY, 页码：1367-1374 , 文章类型： Article，,卷期：2011年6-12] For the last few decades, chemistry has played an important role in protein engineering by providing a variety of synthetic tools such as chemoselective side-chain modifications, chemical conjugation, incorporation of no... Development and in Vitro Characterization of a Novel Bifunctional mu-Agonist/delta-Antagonist Opioid Tetrapeptide [作者：PURINGTON LAUREN C; SOBCZYKKOJIRO KATARZYNA; POGOZHEVA IRINA D; TRAYNOR JOHN R; MOSBERG HENRY I,期刊：ACS CHEMICAL BIOLOGY, 页码：1375-1381 , 文章类型： Article，,卷期：2011年6-12] The development of tolerance to and dependence on opioid analgesics greatly reduces their long-term usefulness. Previous studies have demonstrated that co-administration of a mu-opioid receptor (MOB.) agonist and delta-o... A Small Molecule Mimicking a Phosphatidylinositol (4,5)-Bisphosphate Binding Pleckstrin Homology Domain [作者：MAK LOK HANG; GEORGIADES SAVVAS N; ROSIVATZ EVELYN; WHYTE GILLIAN F; MIRABELLI MARIANNA; VILAR RAMON; WOSCHOLSKI RUDIGER,期刊：ACS CHEMICAL BIOLOGY, 页码：1382-1390 , 文章类型： Article，,卷期：2011年6-12] Inositol phospholipids have emerged as important key players in a wide variety of cellular functions. Among the seven existing inositol phospholipids, phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P(2)) has attracted m... Parsimonious Discovery of Synergistic Drug Combinations [作者：SEVERYN BRYAN; LIEHR ROBERT A; WOLICKI ALEX; NGUYEN KEVIN H; HUDAK EDWARD M; FERRER MARC; CALDWELL JEREMY S; HERMES JEFFREY D; LI JING; TUDOR MATTHEW,期刊：ACS CHEMICAL BIOLOGY, 页码：1391-1398 , 文章类型： Article，,卷期：2011年6-12] Combination therapies that enhance efficacy or permit reduced dosages to be administered have seen great success in a variety of therapeutic applications. More fundamentally, the discovery of epistatic pathway interactio... Cellobiose Dehydrogenase and a Copper-Dependent Polysaccharide Monooxygenase Potentiate Cellulose Degradation by Neurospora crassa [作者：PHILLIPS CHRISTOPHER M; BEESON WILLIAM T; CATE JAMIE H; MARLETTA MICHAEL A,期刊：ACS CHEMICAL BIOLOGY, 页码：1399-1406 , 文章类型： Article，,卷期：2011年6-12] The high cost of enzymes for saccharification of lignocellulosic biomass is a major barrier to the production of second generation biofuels. Using a combination of genetic and biochemical techniques, we report that filam...