- Enhancement of surface ligand display on PLGA nanoparticles with amphiphilic ligand conjugates
[作者:Park, J; Mattessich, T; Jay, SM; Agawu, A; Saltzman, WM; Fahmy, TM,期刊:Journal of controlled release, 页码:109-115 , 文章类型: Article,,卷期:2011年156-1]
- Biodegradable polymeric nanoparticles are widely recognized as efficacious drug delivery vehicles, yet the rational engineering of nanoparticle surfaces in order to improve biodistribution, reduce clearance, and/or impro...
- Biodegradable nanocomposite microparticles as drug delivering injectable cell scaffolds
[作者:Wen, YH; Gallego, MR; Nielsen, LF; Jorgensen, L; Everland, H; Moller, EH; Nielsen, HM,期刊:Journal of controlled release, 页码:11-20 , 文章类型: Article,,卷期:2011年156-1]
- Injectable cell scaffolds play a dual role in tissue engineering by supporting cellular functions and delivering bioactive molecules. The present study aimed at developing biodegradable nanocomposite microparticles with ...
- Recent advances in artificial nerve conduit design: Strategies for the delivery of luminal fillers
[作者:Pabari, A; Yang, SY; Mosahebi, A; Seifalian, AM,期刊:Journal of controlled release, 页码:2-10 , 文章类型: Review,,卷期:2011年156-1]
- Artificial nerve conduits offer an attractive alternative to nerve autografts for the repair of peripheral nerve injuries and several commercially-available conduits are currently on the market. However, at present, util...
- Enhancement of the fraction of the active form of an antitumor drug topotecan via an injectable hydrogel
[作者:Chang, GT; Ci, TY; Yu, L; Ding, JD,期刊:Journal of controlled release, 页码:21-27 , 文章类型: Article,,卷期:2011年156-1]
- Poly(D, L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(D, L-lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) hydrogels were tried as implants to encapsulate antitumor drug topotecan (TPT), a derivative of ca...
- Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels
[作者:Zieris, A; Chwalek, K; Prokoph, S; Levental, KR; Welzel, PB; Freudenberg, U; Werner, C,期刊:Journal of controlled release, 页码:28-36 , 文章类型: Article,,卷期:2011年156-1]
- Effective vascularization is a prerequisite for the success of various different tissue engineering concepts. While simultaneous administration of basic fibroblast growth factor (FGF-2) and vascular endothelial growth fa...
- Sequential release kinetics of two (gentamicin and BMP-2) or three (gentamicin, IGF-I and BMP-2) substances from a one-component polymeric coating on implants
[作者:Strobel, C; Bormann, N; Kadow-Romacker, A; Schmidmaier, G; Wildemann, B,期刊:Journal of controlled release, 页码:37-45 , 文章类型: Article,,卷期:2011年156-1]
- The local application of antibiotics in combination with timely controlled growth factor delivery might be beneficial for the prevention of infections and to stimulate bone healing. Therefore, in this study a variable se...
- Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination
[作者:Verheul, RJ; Slutter, B; Bal, SM; Bouwstra, JA; Jiskoot, W; Hennink, WE,期刊:Journal of controlled release, 页码:46-52 , 文章类型: Article,,卷期:2011年156-1]
- The physical stability of polyelectrolyte nanocomplexes composed of trimethyl chitosan (TMC) and hyaluronic acid (HA) is limited in physiological conditions. This may minimize the favorable adjuvant effects associated wi...
- Combined delivery of dexamethasone and plasmid DNA in an animal model of LPS-induced acute lung injury
[作者:Kim, HA; Park, JH; Lee, S; Choi, JS; Rhim, T; Lee, M,期刊:Journal of controlled release, 页码:60-69 , 文章类型: Article,,卷期:2011年156-1]
- Dexamethasone was conjugated to low molecular weight polyethylenimine (2 kDa, PEI2k). Dexamethasone conjugated PEI2k (PEI2k-Dexa) was evaluated as a combined delivery carrier of dexamethasone and plasmid DNA (pDNA) in an...
- Functionalized organic nanotubes as tubular nonviral gene transfer vector
[作者:Ding, WX; Wada, M; Kameta, N; Minamikawa, H; Shimizu, T; Masuda, M,期刊:Journal of controlled release, 页码:70-75 , 文章类型: Article,,卷期:2011年156-1]
- Tubular nanomaterials are expected to represent a novel nonviral gene transfer vectors due to the unique morphology and potential biological functionalities. Here we rationally constructed functionalized organic nanotube...
- Protein kinase A inhibition modulates the intracellular routing of gene delivery vehicles in HeLa cells, leading to productive transfection
[作者:Rehman, ZU; Hoekstra, D; Zuhorn, IS,期刊:Journal of controlled release, 页码:76-84 , 文章类型: Article,,卷期:2011年156-1]
- Cellular entry of nanoparticles for drug- and gene delivery relies on various endocytic pathways, including clathrin-and caveolae-mediated endocytosis. To improve delivery, i.e., the therapeutic and/or cell biological im...
- Combined MUC1-specific nanobody-tagged PEG-polyethylenimine polyplex targeting and transcriptional targeting of tBid transgene for directed killing of MUC1 over-expressing tumour cells
[作者:Sadeqzadeh, E; Rahbarizadeh, F; Ahmadvand, D; Rasaee, MJ; Parhamifar, L; Moghimi, SM,期刊:Journal of controlled release, 页码:85-91 , 文章类型: Article,,卷期:2011年156-1]
- We provide evidence for combining a single domain antibody (nanobody)-based targeting approach with transcriptional targeting as a safe way to deliver lethal transgenes to MUC1 over-expressing cancer cells. From a nanobo...
- Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure
[作者:Checa-Casalengua, P; Jiang, CH; Bravo-Osuna, I; Tucker, BA; Molina-Martinez, IT; Young, MJ; Herrero-Vanrell, R,期刊:Journal of controlled release, 页码:92-100 , 文章类型: Article,,卷期:2011年156-1]
- The present experimental work describes the use of a novel protein encapsulation method to achieve protection of the biological factor during the microencapsulation procedure. With this aim, the protein is included in po...
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