- In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery
[作者:Cu, Y; Booth, CJ; Saltzman, WM,期刊:Journal of controlled release, 页码:258-264 , 文章类型: Article,,卷期:2011年156-2]
- Intravaginal (ivag) delivery, which is a proven way to confer local protection against STDs contracted via the reproductive tract, is complicated by the mucus gel barrier, the hormone cycle, and the harsh mucosal environ...
- Near-infrared light modulated photothermal effect increases vascular perfusion and enhances polymeric drug delivery
[作者:Melancon, MP; Elliott, AM; Shetty, A; Huang, Q; Stafford, RJ; Li, C,期刊:Journal of controlled release, 页码:265-272 , 文章类型: Article,,卷期:2011年156-2]
- Hyperthermia, which is heating of tumors above 43 degrees C for about 30 min, has been known to modulate vascular permeability for enhanced chemotherapy. However, it is not clear whether a similar effect exists when temp...
- Preparation of polyion complex micelles from poly(ethylene glycol)-block-polyions
[作者:Bayo-Puxan, N; Dufresne, MH; Felber, AE; Castagner, B; Leroux, JC,期刊:Journal of controlled release, 页码:118-127 , 文章类型: Article,,卷期:2011年156-2]
- Polyion complex micelles (PICMs) arise from the spontaneous self-assembly of ionic polymers of opposite charges to form a condensate that is dispersed in aqueous media by a hydrophilic segment, usually poly (ethylene gly...
- Systemic delivery of BH4 anti-apoptotic peptide using CPPs prevents cardiac ischemia-reperfusion injuries in vivo
[作者:Boisguerin, P; Redt-Clouet, C; Franck-Miclo, A; Licheheb, S; Nargeot, J; Barrere-Lemaire, S; Lebleu, B,期刊:Journal of controlled release, 页码:146-153 , 文章类型: Article,,卷期:2011年156-2]
- There is an obvious need to develop pharmacological strategies to protect the heart in patients suffering from acute myocardial infarction. Apoptosis was evidenced as a main contributor of myocardial ischemia-reperfusion...
- Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival
[作者:Dane, KY; Nembrini, C; Tomei, AA; Eby, JK; O'Neil, CP; Velluto, D; Swartz, MA; Inverardi, L; Hubbell, JA,期刊:Journal of controlled release, 页码:154-160 , 文章类型: Article,,卷期:2011年156-2]
- By delivering immunomodulatory drugs in vivo directly to lymph nodes draining an injection site, an opportunity exists to increase drug bioavailability to local immune cells. Importantly, particles smaller than 100 nm ar...
- Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc
[作者:Forbes, CJ; Lowry, D; Geer, L; Veazey, RS; Shattock, RJ; Klasse, PJ; Mitchnick, M; Goldman, L; Doyle, LA; Muldoon, BCO; Woolfson, AD; Moore, JP; Malcolm, RK,期刊:Journal of controlled release, 页码:161-169 , 文章类型: Article,,卷期:2011年156-2]
- Aqueous semi-solid polymeric gels, such as those based on hydroxyethylcellulose (HEC) and polyacrylic acid (e.g. Carbopol (R)), have a long history of use in vaginal drug delivery. However, despite their ubiquity, they o...
- Anthracycline-GnRH derivative bioconjugates with different linkages: Synthesis, in vitro drug release and cytostatic effect
[作者:Schlage, P; Mezo, G; Orban, E; Bosze, S; Manea, M,期刊:Journal of controlled release, 页码:170-178 , 文章类型: Article,,卷期:2011年156-2]
- To increase the selectivity and consequently to minimize the side effects of chemotherapeutic agents, receptor mediated tumor targeting approaches have been developed. In the present work, various anthracycline-GnRH deri...
- Inkjet printing as a novel medicine formulation technique
[作者:Scoutaris, N; Alexander, MR; Gellert, PR; Roberts, CJ,期刊:Journal of controlled release, 页码:179-185 , 文章类型: Article,,卷期:2011年156-2]
- We demonstrate the viability of using an ink-jet printer to produce a formulation capable of controlling the release of a drug. This is shown for the drug felodipine, an antihypertensive, with polyvinyl pirrolidone (PVP)...
- Physical crosslinking modulates sustained drug release from recombinant silk-elastinlike protein polymer for ophthalmic applications
[作者:Teng, WB; Cappello, J; Wu, XY,期刊:Journal of controlled release, 页码:186-194 , 文章类型: Article,,卷期:2011年156-2]
- We evaluated the drug release capability of optically transparent recombinant silk-elastinlike protein polymer, SELP-47K, films to sustainably deliver the common ocular antibiotic, ciprofloxacin. The ciprofloxacin releas...
- Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells
[作者:Chang, KL; Higuchi, Y; Kawakami, S; Yamashita, F; Hashida, M,期刊:Journal of controlled release, 页码:195-202 , 文章类型: Article,,卷期:2011年156-2]
- Chitosan has potential as a biocompatible gene carrier. However, its gene transfection efficiency is low because of its slow endosomal escape rate. Histidine has buffering capacity in the pH range of endosomes/lysosomes....
- Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy
[作者:Yang, XZ; Dou, S; Sun, TM; Mao, CQ; Wang, HX; Wang, J,期刊:Journal of controlled release, 页码:203-211 , 文章类型: Article,,卷期:2011年156-2]
- Delivery of small interfering RNA (siRNA) has been one of the major hurdles for the application of RNA interference in therapeutics. Here, we describe a cationic lipid assisted polymeric nanoparticle system with stealthy...
- Nanoparticle mediated delivery of pure P53 supercoiled plasmid DNA for gene therapy
[作者:Gaspar, VM; Correia, IJ; Sousa, A; Silva, F; Paquete, CM; Queiroz, JA; Sousa, F,期刊:Journal of controlled release, 页码:212-222 , 文章类型: Article,,卷期:2011年156-2]
- The translation of non-viral gene replacement therapies for cancer into clinical application is currently hindered due to known issues associated with the effectiveness of plasmid DNA (pDNA) expression vectors and the pr...
- Ultrasound and microbubble-assisted gene delivery in Achilles tendons: Long lasting gene expression and restoration of fibromodulin KO phenotype
[作者:Delalande, A; Bouakaz, A; Renault, G; Tabareau, F; Kotopoulis, S; Midoux, P; Arbeille, B; Uzbekov, R; Chakravarti, S; Postema, M; Pichon, C,期刊:Journal of controlled release, 页码:223-230 , 文章类型: Article,,卷期:2011年156-2]
- The aim of this study is to deliver genes in Achilles tendons using ultrasound and microbubbles. The rationale is to combine ultrasound-assisted delivery and the stimulation of protein expression induced by US. We found ...
- Hyaluronan-coated nanoparticles: The influence of the molecular weight on CD44-hyaluronan interactions and on the immune response
[作者:Mizrahy, S; Raz, SR; Hasgaard, M; Liu, H; Soffer-Tsur, N; Cohen, K; Dvash, R; Landsman-Milo, D; Bremer, MGEG; Moghimi, SM; Peer, D,期刊:Journal of controlled release, 页码:231-238 , 文章类型: Article,,卷期:2011年156-2]
- Hyaluronan (HA), a naturally occurring glycosaminoglycan, exerts different biological functions depending on its molecular weight ranging from 4000-10M Da. While high Mw HA (HMw-HA) is considered as anti-inflammatory, lo...
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