- Intravenously delivered glucocorticoid liposomes inhibit osteoclast activity and bone erosion in murine antigen-induced arthritis
[作者:Hofkens, W; Grevers, LC; Walgreen, B; de Vries, TJ; Leenen, PJM; Everts, V; Storm, G; van den Berg, WB; van Lent, PL,期刊:Journal of controlled release, 页码:363-369 , 文章类型: Article,,卷期:2011年152-3]
- The objective of this study was to determine the effect of systemic delivery of prednisolone phosphate (PLP) encapsulated within long circulating 'stealth' liposomes on bone erosion and osteoclast activity during experim...
- Anionic polymers for decreased toxicity and enhanced in vivo delivery of siRNA complexed with cationic liposomes
[作者:Schlegel, A; Largeau, C; Bigey, P; Bessodes, M; Lebozec, K; Scherman, D; Escriou, V,期刊:Journal of controlled release, 页码:393-401 , 文章类型: Article,,卷期:2011年152-3]
- We recently reported a cationic lipid-based vector of siRNA, termed siRNA lipoplex that was very efficient in specific gene silencing, both in cell culture and in mouse disease models. To be more efficient, this vector i...
- Reversal of doxorubicin-resistance by multifunctional nanoparticles in MCF-7/ADR cells
[作者:Shieh, MJ; Hsu, CY; Huang, LY; Chen, HY; Huang, FH; Lai, PS,期刊:Journal of controlled release, 页码:418-425 , 文章类型: Article,,卷期:2011年152-3]
- The efficacy of many chemotherapeutic agents is reduced in cells that have developed multiple drug resistance (MDR). To address this important problem, a biodegradable polymer was coupled to a photosensitizer and the res...
- Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes
[作者:Xiang, Y; Liang, L; Wang, XQ; Wang, JC; Zhang, X; Zhang, Q,期刊:Journal of controlled release, 页码:402-410 , 文章类型: Article,,卷期:2011年152-3]
- The chlorotoxin (CITx). a scorpion-derived peptide, binding to gliomas with high specificity, was firstly applied to establish the CITx-modified doxorubicin (DOX)-loaded liposome delivery system for targeting the brain g...
- Formulation and in vivo evaluation of sodium alendronate spray-dried microparticles intended for lung delivery
[作者:Cruz, L; Fattal, E; Tasso, L; Freitas, GC; Carregaro, AB; Guterres, SS; Pohlmann, AR; Tsapis, N,期刊:Journal of controlled release, 页码:370-375 , 文章类型: Article,,卷期:2011年152-3]
- Spray-dried powders for lung delivery of sodium alendronate (SA) were prepared from hydroalcoholic solutions. Formulations display geometric particle size below to 12 mu m and spherical shape associated to a hollow struc...
- A laboratory-scale device for the straightforward production of uniform, small sized cell microcapsules with long-term cell viability
[作者:Kontturi, LS; Yliperttula, M; Toivanen, P; Maatta, A; Maatta, AM; Urtti, A,期刊:Journal of controlled release, 页码:376-381 , 文章类型: Article,,卷期:2011年152-3]
- Microencapsulated and genetically engineered cells may be used for prolonged delivery of therapeutically active proteins. The objective of this study was to develop a simple, inexpensive and flexible laboratory-scale dev...
- The effect of dextrin-rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouse
[作者:Hardwicke, JT; Hart, J; Bell, A; Duncan, R; Thomas, DW; Moseley, R,期刊:Journal of controlled release, 页码:411-417 , 文章类型: Article,,卷期:2011年152-3]
- Chronic wounds, such as ulceration of the lower limb, represent a significant clinical challenge in today's ageing society. With the aim of identifying improved therapeutics, we have previously described a bioresponsive,...
- Tunable elastin-like polypeptide hollow sphere as a high payload and controlled delivery gene depot
[作者:Dash, BC; Mahor, S; Carroll, O; Mathew, A; Wang, WX; Woodhouse, KA; Pandit, A,期刊:Journal of controlled release, 页码:382-392 , 文章类型: Article,,卷期:2011年152-3]
- Self-assembly driven processes can be utilized to produce a variety of nanostructures useful for various in vitro and in vivo applications. Characteristics such as size, stability, biocompatibility, high therapeutic load...
- Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends
[作者:Polat, BE; Hart, D; Langer, R; Blankschtein, D,期刊:Journal of controlled release, 页码:330-348 , 文章类型: Review,,卷期:2011年152-3]
- The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoresis. The use of therapeutic and high frequencies of ultrasound (>= 0.7 MHz) for sonophoresis (HFS) d...
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