- beta-Barrel Topology of Alzheimer's beta-Amyloid Ion Channels
[作者:Jang, H; Arce, FT; Ramachandran, S; Capone, R; Lal, R; Nussinov, R,期刊:Journal of Molecular Biology, 页码:917-934 , 文章类型: Article,,卷期:2010年404-5]
- Emerging evidence supports the ion channel mechanism for Alzheimer's disease pathophysiology wherein small beta-amyloid (A beta) oligomers insert into the cell membrane, forming toxic ion channels and destabilizing the c...
- Structure of a Conserved Retroviral RNA Packaging Element by NMR Spectroscopy and Cryo-Electron Tomography
[作者:Miyazaki, Y; Irobalieva, RN; Tolbert, BS; Smalls-Mantey, A; Iyalla, K; Loeliger, K; D'Souza, V; Khant, H; Schmid, MF; Garcia, EL; Telesnitsky, A; Chiu, W; Summers, MF,期刊:Journal of Molecular Biology, 页码:751-772 , 文章类型: Article,,卷期:2010年404-5]
- The 5'-untranslated regions of all gammaretroviruses contain a conserved "double-hairpin motif" (Psi(CD)) that is required for genome packaging Both hairpins (SL-C and SL-D) contain GACG tetraloops that, in isolated RNAs...
- Reversal of a Mutator Activity by a Nearby Fidelity-Neutral Substitution in the RB69 DNA Polymerase Binding Pocket
[作者:Trzemecka, A; Jacewicz, A; Carver, GT; Drake, JW; Bebenek, A,期刊:Journal of Molecular Biology, 页码:778-793 , 文章类型: Article,,卷期:2010年404-5]
- Phage RB69 B-family DNA polymerase is responsible for the overall high fidelity of RB69 DNA synthesis Fidelity is compromised when conserved Tyr567, one of the residues that form the nascent polymerase base-pair binding ...
- SAM Recognition and Conformational Switching Mechanism in the Bacillus subtilis yitJ S Box/SAM-I Riboswitch
[作者:Lu, CR; Ding, F; Chowdhury, A; Pradhan, V; Tomsic, J; Holmes, WM; Henkin, TM; Ke, AL,期刊:Journal of Molecular Biology, 页码:803-818 , 文章类型: Article,,卷期:2010年404-5]
- S-box (SAM-I) nboswitches are a widespread class of nboswitches involved in the regulation of sulfur metabolism in Gram-positive bacteria We report here the 3 0-angstrom crystal structure of the aptamer domain of the Bac...
- The Extended Conformation of the 2.9-angstrom Crystal Structure of the Three-PASTA Domain of a Ser/Thr Kinase from the Human Pathogen Staphylococcus aureus
[作者:Paracuellos, P; Ballandras, A; Robert, X; Kahn, R; Herve, M; Mengin-Lecreulx, D; Cozzone, AJ; Duclos, B; Gouet, P,期刊:Journal of Molecular Biology, 页码:847-858 , 文章类型: Article,,卷期:2010年404-5]
- PASTA (penicillin-binding protein and serine/threonine kinase associated) modules are found in penicillin-binding proteins and bacterial serine/threonine kinases mainly from Gram-positive Firmicutes and Actinobacteria Th...
- Enhanced Specificity of Mint Geranyl Pyrophosphate Synthase by Modifying the R-Loop Interactions
[作者:Hsieh, FL; Chang, TH; Ko, TP; Wang, AHJ,期刊:Journal of Molecular Biology, 页码:859-873 , 文章类型: Article,,卷期:2010年404-5]
- Isoprenoids, most of them synthesized by prenyltransferases (PTSs), are a class of important biologically active compounds with diverse functions The mint geranyl pyrophosphate synthase (GPPS) is a heterotetramer compose...
- Crystal Structures of NodS N-Methyltransferase from Bradyrhizobium japonicum in Ligand-Free Form and as SAH Complex
[作者:Cakici, O; Sikorski, M; Stepkowski, T; Bujacz, G; Jaskolski, M,期刊:Journal of Molecular Biology, 页码:874-889 , 文章类型: Article,,卷期:2010年404-5]
- NodS is an S-adenosyl-L-methionine (SAM)-dependent N-methyltransferase that is involved in the biosynthesis of Nod factor (NF) in rhizobia, which are bacterial symbionts of legume plants NF is a modified chitooligosaccha...
- Molecular Mechanisms Modulating Glutamate Kinase Activity. Identification of the Proline Feedback Inhibitor Binding Site
[作者:Perez-Arellano, I; Carmona-Alvarez, F; Gallego, J; Cervera, J,期刊:Journal of Molecular Biology, 页码:890-901 , 文章类型: Article,,卷期:2010年404-5]
- Proline, the feedback inhibitor of bacterial glutamate kinase (GK) and plant pyrroline-5-carboxylate synthase (P5CS) enzymes, is a key regulator of the osmotic and redox balance of cells Using kinetic assays, site-direct...
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