- Alternative Oligomeric States of the Yeast Rvb1/Rvb2 Complex Induced by Histidine Tags
[作者:Cheung, KLY; Huen, J; Kakihara, Y; Houry, WA; Ortega, J,期刊:Journal of Molecular Biology, 页码:478-492 , 文章类型: Article,,卷期:2010年404-3]
- Rvb1 and Rvb2 are essential AAA(+) (ATPases associated with diverse cellular activities) helicases, which are important components of critical complexes such as chromatin remodeling and telomerase complexes. The oligomer...
- Gradual Adaptive Changes of a Protein Facing High Salt Concentrations
[作者:Coquelle, N; Talon, R; Juers, DH; Girard, E; Kahn, R; Madern, D,期刊:Journal of Molecular Biology, 页码:493-505 , 文章类型: Article,,卷期:2010年404-3]
- Several experimental techniques were applied to unravel fine molecular details of protein adaptation to high salinity. We compared four homologous enzymes, which suggested a new halo-adaptive state in the process of mole...
- Coupling Trans location with Nucleic Acid Unwinding by NS3 Helicase
[作者:Yu, J; Cheng, W; Bustamante, C; Oster, G,期刊:Journal of Molecular Biology, 页码:439-455 , 文章类型: Article,,卷期:2010年404-3]
- We present a semiquantitative model for translocation and unwinding activities of monomeric nonstructural protein 3 (N53) helicase. The model is based on structural, biochemical, and single-molecule measurements. The mod...
- The Clp Chaperones and Proteases of the Human Malaria Parasite Plasmodium falciparum
[作者:El Bakkouri, M; Pow, A; Mulichak, A; Cheung, KLY; Artz, JD; Amani, M; Fell, S; de Koning-Ward, TF; Goodman, CD; McFaddens, GI; Ortega, J; Hui, R; Houry, WA,期刊:Journal of Molecular Biology, 页码:456-477 , 文章类型: Article,,卷期:2010年404-3]
- The Clp chaperones and proteases play an important role in protein homeostasis in the cell. They are highly conserved across prokaryotes and found also in the mitochondria of eukaryotes and the chloroplasts of plants. Th...
- The Three-Dimensional Structure of AKR11B4, a Glycerol Dehydrogenase from Gluconobacter oxydans, Reveals a Tryptophan Residue as an Accelerator of Reaction Turnover
[作者:Richter, N; Breicha, K; Hummel, W; Niefind, K,期刊:Journal of Molecular Biology, 页码:353-362 , 文章类型: Article,,卷期:2010年404-3]
- The NADP-dependent glycerol dehydrogenase (EC 1.1.1.72) from Gluconobacter oxydans is a member of family 11 of the aldo-keto reductase (AKR) enzyme superfamily; according to the systematic nomenclature within the AICR su...
- Mouse ApoM Displays an Unprecedented Seven-Stranded Lipocalin Fold: Folding Decoy or Alternative Native Fold?
[作者:Sevvana, M; Kassler, K; Ahnstrom, J; Weiler, S; Dahlback, B; Sticht, H; Muller, YA,期刊:Journal of Molecular Biology, 页码:363-371 , 文章类型: Article,,卷期:2010年404-3]
- Mouse apolipoprotein M (m-apoM) displays a 79% sequence identity to human apolipoprotein M (h-apoM). Both proteins are apolipoproteins associated with high-density lipoproteins, with similar anticipated biological functi...
- Insights into Substrate Specificity of Geranylgeranyl Reductases Revealed by the Structure of Digeranylgeranylglycerophospholipid Reductase, an Essential Enzyme in the Biosynthesis of Archaeal Membrane Lipids
[作者:Xu, QP; Eguchi, T; Mathews, II; Rife, CL; Chiu, HJ; Farr, CL; Feuerhelm, J; Jaroszewski, L; Klock, HE; Knuth, MW; Miller, MD; Weekes, D; Elsliger, MA; Deacon, AM; Godzik, A; Lesley, SA; Wilson, IA,期刊:Journal of Molecular Biology, 页码:403-417 , 文章类型: Article,,卷期:2010年404-3]
- Archaeal membrane lipids consist of branched, saturated hydrocarbons distinct from those found in bacteria and eukaryotes. Digeranylgeranylglycerophospholipid reductase (DGGR) catalyzes the hydrogenation process that con...
- A Divergent Substrate-Binding Loop within the Pro-oncogenic Protein Anterior Gradient-2 Forms a Docking Site for Reptin
[作者:Maslon, MM; Hrstka, R; Vojtesek, B; Hupp, TR,期刊:Journal of Molecular Biology, 页码:418-438 , 文章类型: Article,,卷期:2010年404-3]
- Anterior gradient-2 (AGR2) functions in a range of biological systems, including goblet cell formation, limb regeneration, inhibition of p53, and metastasis. There are no well-validated binding proteins for AGR2 protein ...
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