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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共22条记录   Computational Mapping of Anchoring Spots on Protein Surfaces [作者：Ben-Shimon, A; Eisenstein, M,期刊：Journal of Molecular Biology, 页码：259-277 , 文章类型： Article，,卷期：2010年402-1] Protein protein and protein peptide interactions are often controlled by few strong contacts that involve hot spot residues. Computational detection of such contacts, termed here anchoring spots, is important for underst... Long-Distance Communication in the HDV Ribozyme: Insights from Molecular Dynamics and Experiments [作者：Veeraraghavan, N; Bevilacqua, PC; Hammes-Schiffer, S,期刊：Journal of Molecular Biology, 页码：278-291 , 文章类型： Article，,卷期：2010年402-1] The hepatitis delta virus ribozyme is a small, self-cleaving RNA with a compact tertiary structure and buried active site that is important in the life cycle of the virus. The ribozyme's function in nature is to cleave a... Conformational Switching of the Diphtheria Toxin T Domain [作者：Rodnin, MV; Kyrychenko, A; Kienker, P; Sharma, O; Posokhov, YO; Collier, RJ; Finkelstein, A; Ladokhin, AS,期刊：Journal of Molecular Biology, 页码：1-7 , 文章类型： Article，,卷期：2010年402-1] The diphtheria toxin T domain translocates the catalytic C domain across the endosomal membrane in response to acidification. To elucidate the role of histidine protonation in modulating pH-dependent membrane action of t... Crystal Structure of the GerBC Component of a Bacillus subtilis Spore Germinant Receptor [作者：Li, YF; Setlow, B; Setlow, P; Hao, B,期刊：Journal of Molecular Biology, 页码：8-16 , 文章类型： Article，,卷期：2010年402-1] The nutrient germinant receptors (nGRs) of spores of Bacillus species are clusters of three proteins that play a critical role in triggering the germination of dormant spores in response to specific nutrient molecules... Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b [作者：Garcia, BL; Ramyar, KX; Tzekou, A; Ricklin, D; McWhorter, WJ; Lambris, JD; Geisbrecht, BV,期刊：Journal of Molecular Biology, 页码：17-29 , 文章类型： Article，,卷期：2010年402-1] The human complement system plays an essential role in innate and adaptive immunity by marking and eliminating microbial intruders. Activation of complement on foreign surfaces results in proteolytic cleavage of compleme... The M-Domain Controls Hsp104 Protein Remodeling Activity in an Hsp70/Hsp40-Dependent Manner [作者：Sielaff, B; Tsai, FTF,期刊：Journal of Molecular Biology, 页码：30-37 , 文章类型： Article，,卷期：2010年402-1] Yeast Hsp104 is a ring-forming ATP-dependent protein disaggregase that, together with the cognate Hsp70 chaperone system, has the remarkable ability to rescue stress-damaged proteins from a previously aggregated state. B... Nebulin: A Study of Protein Repeat Evolution [作者：Bjorklund, AK; Light, S; Sagit, R; Elofsson, A,期刊：Journal of Molecular Biology, 页码：38-51 , 文章类型： Article，,卷期：2010年402-1] Protein domain repeats are common in proteins that are central to the organization of a cell, in particular in eukaryotes. They are known to evolve through internal tandem duplications. However, the understanding of the ... Multiplexing RMCE: Versatile Extensions of the Flp-Recombinase-Mediated Cassette-Exchange Technology [作者：Turan, S; Kuehle, J; Schambach, A; Baum, C; Bode, J,期刊：Journal of Molecular Biology, 页码：52-69 , 文章类型： Article，,卷期：2010年402-1] There are strong indications, but as yet no proof, that extended 48-bp Flp recombinase targets (FRTs) represent unique targets in all eukaryotic genomes investigated, and that recombinase-mediated cassette exchange is no... Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O-6-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage [作者：Groth, P; Auslander, S; Majumder, MM; Schultz, N; Johansson, F; Petermann, E; Helleday, T,期刊：Journal of Molecular Biology, 页码：70-82 , 文章类型： Article，,卷期：2010年402-1] Even though DNA alkylating agents have been used for many decades in the treatment of cancer, it remains unclear what happens when replication forks encounter alkylated DNA. Here, we used the DNA fibre assay to study the... Molecular Basis for the Recognition of Phosphorylated STAT1 by Importin alpha 5 [作者：Nardozzi, J; Wenta, N; Yasuhara, N; Vinkemeier, U; Cingolani, G,期刊：Journal of Molecular Biology, 页码：83-100 , 文章类型： Article，,卷期：2010年402-1] Interferon-gamma stimulation triggers tyrosine phosphorylation of the transcription factor STAT1 at position 701, which is associated with switching from carrier-independent nucleocytoplasmic shuttling to carrier-mediate... Translation Driven by Picornavirus IRES Is Hampered from Sindbis Virus Replicons: Rescue by Poliovirus 2A Protease [作者：Sanz, MA; Welnowska, E; Redondo, N; Carrasco, L,期刊：Journal of Molecular Biology, 页码：101-117 , 文章类型： Article，,卷期：2010年402-1] Alphavirus replicons are very useful for analyzing different aspects of viral molecular biology. They are also useful tools in the development of new vaccines and highly efficient expression of heterologous genes. We hav... The Role of the T7 Gp2 Inhibitor of Host RNA Polymerase in Phage Development [作者：Savalia, D; Robins, W; Nechaev, S; Molineux, I; Severinov, K,期刊：Journal of Molecular Biology, 页码：118-126 , 文章类型： Article，,卷期：2010年402-1] Bacteriophage T7 relies on its own RNA polymerase (RNAp) to transcribe its middle and late genes. Early genes, which include the viral RNAp gene, are transcribed by the host RNAp from three closely spaced strong promoter... Orientation of Small Multidrug Resistance Transporter Subunits in the Membrane: Correlation with the Positive-Inside Rule [作者：Kolbusz, MA; ter Horst, R; Slotboom, DJ; Lolkema, JS,期刊：Journal of Molecular Biology, 页码：127-138 , 文章类型： Article，,卷期：2010年402-1] Small multidrug resistance (SMR) transport proteins provide a model for the evolution of larger two-domain transport proteins. The orientation in the membrane of 27 proteins from the SMR family was determined using the r... HIV Fusion Peptide Penetrates, Disorders, and Softens T-Cell Membrane Mimics [作者：Tristram-Nagle, S; Chan, R; Kooijman, E; Uppamoochikkal, P; Qiang, W; Weliky, DP; Nagle, JF,期刊：Journal of Molecular Biology, 页码：139-153 , 文章类型： Article，,卷期：2010年402-1] This work investigates the interaction of N-terminal gp41 fusion peptide (FP) of human immunodeficiency virus type 1 (HIV-1) with model membranes in order to elucidate how FP leads to fusion of HIV and T-cell membranes. ... Use of RNA Tertiary Interaction Modules for the Crystallisation of the Spliceosomal snRNP Core Domain [作者：Leung, AKW; Kambach, C; Kondo, Y; Kampmann, M; Jinek, M; Nagai, K,期刊：Journal of Molecular Biology, 页码：154-164 , 文章类型： Article，,卷期：2010年402-1] RNA is known to perform diverse roles in the cell, often as ribonucleoprotein (RNP) particles. While the crystal structure of these RNP particles could provide crucial insights into their functions, crystallographic work... Cooperative Binding of MgATP and MgADP in the Trimeric P-II Protein GlnK2 from Archaeoglobus fulgidus [作者：Helfmann, S; Lu, W; Litz, C; Andrade, SLA,期刊：Journal of Molecular Biology, 页码：165-177 , 文章类型： Article，,卷期：2010年402-1] P-II-like proteins, such as GlnK, found in a wide variety of organisms from prokaryotes to plants constitute a family of cytoplasmic signaling proteins that play a central regulatory role in the assimilation of nitrogen ...