- Quantitative Proteomic Analysis of Ribosome Assembly and Turnover In Vivo
[作者:Sykes, MT; Shajani, Z; Sperling, E; Beck, AH; Williamson, JR,期刊:Journal of Molecular Biology, 页码:331-345 , 文章类型: Article,,卷期:2010年403-3]
- Although high-resolution structures of the ribosome have been solved in a series of functional states, relatively little is known about how the ribosome assembles, particularly in vivo. Here, a general method is presente...
- A Structural Hinge in Eukaryotic MutY Homologues Mediates Catalytic Activity and Rad9-Rad1-Hus1 Checkpoint Complex Interactions
[作者:Luncsford, PJ; Chang, DY; Shi, GL; Bernstein, J; Madabushi, A; Patterson, DN; Lu, AL; Toth, EA,期刊:Journal of Molecular Biology, 页码:351-370 , 文章类型: Article,,卷期:2010年403-3]
- The DNA glycosylase MutY homologue (MYH or MUTYH) removes adenines misincorporated opposite 8-oxoguanine as part of the base excision repair pathway. Importantly, defects in human MYH (hMYH) activity cause the inherited ...
- Computational Design of a Chain-Specific Tetracycline Repressor Heterodimer
[作者:Stiebritz, MT; Wengrzik, S; Klein, DL; Richter, JP; Srebrzynski, A; Weiler, S; Muller, YA,期刊:Journal of Molecular Biology, 页码:371-385 , 文章类型: Article,,卷期:2010年403-3]
- The specificity and selectivity of protein protein interactions are of central importance for many biological processes, including signal transduction and transcription control. We used the in-house side-chain packing pr...
- Identification and Characterization of a Misfolded Monomeric Serpin Formed at Physiological Temperature
[作者:Pearce, MC; Powers, GA; Feil, SC; Hansen, G; Parker, MW; Bottomley, SP,期刊:Journal of Molecular Biology, 页码:459-467 , 文章类型: Article,,卷期:2010年403-3]
- The native serpin state is kinetically trapped. However, under mildly destabilizing conditions, the conformational landscape changes, and a number of nonnative conformations with increased stability can be readily formed...
- The Solution Structure of the C-Terminal Ig-like Domain of the Bacteriophage lambda Tail Tube Protein
[作者:Pell, LG; Gasmi-Seabrook, GMC; Morais, M; Neudecker, P; Kanelis, V; Bona, D; Donaldson, LW; Edwards, AM; Howell, PL; Davidson, AR; Maxwel, KL,期刊:Journal of Molecular Biology, 页码:468-479 , 文章类型: Article,,卷期:2010年403-3]
- Immunoglobulin (Ig)-like domains are found frequently on the surface of tailed double-stranded DNA bacteriophages, yet their functional role remains obscure. Here, we have investigated the structure and function of the C...
- The Evolution and Structure Prediction of Coiled Coils across All Genomes
[作者:Rackham, OJL; Madera, M; Armstrong, CT; Vincent, TL; Woolfson, DN; Gough, J,期刊:Journal of Molecular Biology, 页码:480-493 , 文章类型: Article,,卷期:2010年403-3]
- Coiled coils are a-helical interactions found in many natural proteins. Various sequence-based coiled-coil predictors are available, but key issues remain: oligomeric state and protein protein interface prediction and ex...
|