- Internalizing Cancer Antibodies from Phage Libraries Selected on Tumor Cells and Yeast-Displayed Tumor Antigens
[作者:Zhou, Y; Zou, H; Zhang, SY; Marks, JD,期刊:Journal of Molecular Biology, 页码:88-99 , 文章类型: Article,,卷期:2010年404-1]
- A number of approaches have been utilized to generate antibodies to cancer cell surface receptors that can be used as potential therapeutics. A number of these therapeutic approaches, including antibody drug conjugates, ...
- Structural and Biochemical Studies Elucidate the Mechanism of Rhamnogalacturonan Lyase from Aspergillus aculeatus
[作者:Jensen, MH; Otten, H; Christensen, U; Borchert, TV; Christensen, LLH; Larsen, S; Lo Leggiol, L,期刊:Journal of Molecular Biology, 页码:100-111 , 文章类型: Article,,卷期:2010年404-1]
- We present here the first experimental evidence for bound substrate in the active site of a rhamnogalacturonan lyase belonging to family 4 of polysaccharide lyases, Aspergillus aculeatus rhamnogalacturonan lyase (RGL4). ...
- Structural Characterization of the Stem-Stem Dimerization Interface between Prolactin Receptor Chains Complexed with the Natural Hormone
[作者:van Agthoven, J; Zhang, C; Tallet, E; Raynal, B; Hoos, S; Baron, B; England, P; Goffin, V; Broutin, I,期刊:Journal of Molecular Biology, 页码:112-126 , 文章类型: Article,,卷期:2010年404-1]
- The most promising approach to targeting the tumor-growth-promoting actions of prolactin (PRL) mediated by its autocrine/paracrine pathway has been the development of specific PRL receptor (PRLR) antagonists. However, th...
- High-Resolution Structure of the Nitrile Reductase QueF Combined with Molecular Simulations Provide Insight into Enzyme Mechanism
[作者:Kim, Y; Zhou, M; Moy, S; Morales, J; Cunningham, MA; Joachimiak, A,期刊:Journal of Molecular Biology, 页码:127-137 , 文章类型: Article,,卷期:2010年404-1]
- Here, we report the 1.53-angstrom crystal structure of the enzyme 7-cyano-7-deazaguanine reductase (QueF) from Vibrio cholerae, which is responsible for the complete reduction of a nitrile (C N) bond to a primary amine ...
- Coevolution Predicts Direct Interactions between mtDNA-Encoded and nDNA-Encoded Subunits of Oxidative Phosphorylation Complex I
[作者:Gershoni, M; Fuchs, A; Shani, N; Fridman, Y; Corral-Debrinski, M; Aharoni, A; Frishman, D; Mishmar, D,期刊:Journal of Molecular Biology, 页码:158-171 , 文章类型: Article,,卷期:2010年404-1]
- Despite years of research, the structure of the largest mammalian oxidative phosphorylation (OXPHOS) complex, NADH ubiquinone oxidoreductase (complex I), and the interactions among its 45 subunits are not fully understoo...
- Peroxisome Proliferator-Activated Receptor alpha Controls Hepatic Heme Biosynthesis Through ALAS1 (Retraction of vol 388, pg 225, 2009)
[作者:Degenhardt, T; Vaisanen, S; Rakhshandehroo, M; Kersten, S; Carlberg, C,期刊:Journal of Molecular Biology, 页码:172-172 , 文章类型: Correction,,卷期:2010年404-1]
- The Transcription Factor Spn1 Regulates Gene Expression via a Highly Conserved Novel Structural Motif
[作者:Pujari, V; Radebaugh, CA; Chodaparambil, JV; Muthurajan, UM; Almeida, AR; Fischbeck, JA; Luger, K; Stargell, LA,期刊:Journal of Molecular Biology, 页码:1-15 , 文章类型: Article,,卷期:2010年404-1]
- Spn1/Iws1 plays essential roles in the regulation of gene expression by RNA polymerase II (RNAPII), and it is highly conserved in organisms ranging from yeast to humans. Spn1 physically and/or genetically interacts with ...
- Sin Resolvase Catalytic Activity and Oligomerization State are Tightly Coupled
[作者:Mouw, KW; Steiner, AM; Ghirlando, R; Li, NS; Rowland, SJ; Boocock, MR; Stark, WM; Piccirilli, JA; Rice, PA,期刊:Journal of Molecular Biology, 页码:16-33 , 文章类型: Article,,卷期:2010年404-1]
- Serine recombinases promote specific DNA rearrangements by a cut-and-paste mechanism that involves cleavage of all four DNA strands at two sites recognized by the enzyme. Dissecting the order and timing of these cleavage...
- Translesion Synthesis across Abasic Lesions by Human B-Family and Y-Family DNA Polymerases alpha, delta, eta, I, K, and REV1
[作者:Choi, JY; Lim, S; Kim, EJ; Jo, A; Guengerich, FP,期刊:Journal of Molecular Biology, 页码:34-44 , 文章类型: Article,,卷期:2010年404-1]
- Abasic (apurinic/apyrimidinic, AP) sites are the most common DNA lesions formed in cells, induce severe blocks to DNA replication, and are highly mutagenic. Human Y-family translesion DNA polymerases (pols) such as pols ...
- Loop-Swapped Chimeras of the Agouti-Related Protein and the Agouti Signaling Protein Identify Contacts Required for Melanocortin 1 Receptor Selectivity and Antagonism
[作者:Patel, MP; Fabersunne, CSC; Yang, YK; Kaelin, CB; Barsh, GS; Millhauser, GL,期刊:Journal of Molecular Biology, 页码:45-55 , 文章类型: Article,,卷期:2010年404-1]
- Agouti-related protein (AgRP) and agouti signaling protein (ASIP) are homologs that play critical roles in energy balance and pigmentation, respectively, by functioning as antagonistic ligands at their cognate melanocort...
- Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution
[作者:Campeotto, I; Bolt, AH; Harman, TA; Dennis, C; Trinh, CH; Phillips, SEV; Nelson, A; Pearson, AR; Berry, A,期刊:Journal of Molecular Biology, 页码:56-69 , 文章类型: Article,,卷期:2010年404-1]
- The substrate specificity of Escherichia coli N-acetylneuraminic acid lyase was previously switched from the natural condensation of pyruvate with N-acetylmannosamine, yielding N-acetylneuraminic acid, to the aldol conde...
|