- Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1
[作者:Glatt, H; Rost, K; Frank, H; Seidel, A; Kollock, R,期刊:Archives of Biochemistry and Biophysics , 页码:196-205 , 文章类型: Article,,卷期:2008年477-2]
- Methylated polycyclic aromatic hydrocarbons can be metabolically activated via benzylic hydroxylation and sulpho Conjugation to reactive esters, which can induce mutations and tumours. Yet, further oxidation of the alcoh...
- Calpain inhibition delays neutrophil apoptosis via cyclic AMP-independent activation of protein kinase A and protein kinase A-mediated stabilization of Mcl-1 and X-linked inhibitor of apoptosis (XIAP)
[作者:Ozaki, Y; Kato, T; Kitagawa, M; Fujita, H; Kitagawa, S,期刊:Archives of Biochemistry and Biophysics , 页码:227-231 , 文章类型: Article,,卷期:2008年477-2]
- Human neutrophils underwent spontaneous apoptosis, which was accompanied with proteasome-mediated degradation of Mcl-1 and X-linked inhibitor of apoptosis (XIAP). Calpain inhibitors (PD150606 and N-acetyl-LeU-Leu-Nle-CHO...
- Characterization of human DHRS4: An inducible short-chain dehydrogenase/reductase enzyme with 3 beta-hydroxysteroid dehydrogenase activity
[作者:Matsunaga, T; Endo, S; Maeda, S; Ishikura, S; Tajima, K; Tanaka, N; Nakamura, KT; Imamura, Y; Hara, A,期刊:Archives of Biochemistry and Biophysics , 页码:339-347 , 文章类型: Article,,卷期:2008年477-2]
- Human DHRS4 is a peroxisomal member of the short-chain dehydrogenase/reductase superfamily, but its enzymatic properties, except for displaying NADP(H)-dependent retinol dehydrogenase/reductase activity, are unknown. We ...
- Mass spectrometric investigation of the DNA-binding properties of an anthracycline with two trisaccharide chains
[作者:Kelso, C; Tillott, V; Rojas, JD; Furlan, RLA; Padilla, G; Beck, JL,期刊:Archives of Biochemistry and Biophysics , 页码:348-355 , 文章类型: Article,,卷期:2008年477-2]
- Cosmomycin D (CosD) is an anthracycline that has two trisaccharide chains linked to its ring system. Gel electrophoresis showed that CosD formed stable complexes with plasmid DNA under conditions where daunorubicin (Dn) ...
- Structural analysis of PI3-kinase isoforms: Identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors
[作者:Zvelebil, MJ; Waterfield, MD; Shuttleworth, SJ,期刊:Archives of Biochemistry and Biophysics , 页码:404-410 , 文章类型: Article,,卷期:2008年477-2]
- A series of small molecule, ATP-competitive phosphoinositide 3-kinase inhibitors have been examined in homology models of the four class 1 isoforms, p110 alpha, p110 beta, p110 delta and p110 gamma. This analysis provide...
- Pilosulin 5, a novel histamine-releasing peptide of the Australian ant, Myrmecia pilosula (Jack Jumper Ant)
[作者:Inagaki, H; Akagi, M; Imai, HT; Taylor, RW; Wiese, MD; Davies, NW; Kubo, T,期刊:Archives of Biochemistry and Biophysics , 页码:411-416 , 文章类型: Article,,卷期:2008年477-2]
- Venom of the Australian ant species Myrmecia pilosula contains a number of allergenic peptides including pilosulins. To obtain novel cDNA clones that encode the pilosulin-related bioactive peptides, mRNA of M. pilosula s...
- The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal
[作者:Forman, HJ; Fukuto, JM; Miller, T; Zhang, HQ; Rinna, A; Levy, S,期刊:Archives of Biochemistry and Biophysics , 页码:183-195 , 文章类型: Review,,卷期:2008年477-2]
- During the past several years, major advances have been made in understanding how reactive oxygen species (ROS) and nitrogen species (RNS) participate in signal transduction. Identification of the specific targets and th...
- Characterization of a cysteine protease from Tritrichomonas foetus that induces host-cell apoptosis
[作者:Lucas, JJ; Hayes, GR; Kalsi, HK; Gilbert, RO; Choe, Y; Craik, CS; Singh, BN,期刊:Archives of Biochemistry and Biophysics , 页码:239-243 , 文章类型: Article,,卷期:2008年477-2]
- Tritrichomonas foetus is a serious veterinary pathogen, causing bovine trichomoniasis and affecting cattle herds world-wide, resulting in inflammation of the genital tract, infertility and huge economic losses. The paras...
- Purinergic (ATP) signaling stimulates JNK1 but not JNK2 MAPK in osteoblast-like cells: Contribution of intracellular Ca2+ release, stress activated and L-voltage-dependent calcium influx, PKC and Src kinases
[作者:Katz, S; Boland, R; Santillan, G,期刊:Archives of Biochemistry and Biophysics , 页码:244-252 , 文章类型: Article,,卷期:2008年477-2]
- This work shows that ATP activates JNK1, but not JNK2, in rat osteoblasts and RCS-A 17/2.8 osteoblast-like cells. In RCS-A 17/2.8 cells ATP induced JNK1 phosphorylation in a close- and time-dependent manner. JNK1 phospho...
- PASK (proline-alanine-rich Ste20-related kinase) binds to tubulin and microtubules and is involved in microtubule stabilization
[作者:Tsutsumi, T; Kosaka, T; Ushiro, H; Kimura, K; Honda, T; Kayahara, T; Mizoguchi, A,期刊:Archives of Biochemistry and Biophysics , 页码:267-278 , 文章类型: Article,,卷期:2008年477-2]
- Proline-alanine-rich Ste20-related kinase (PASK, also referred to as SPAK) has been linked to ion transport regulation. Here, we report two novel activities of PASK: binding to tubulin and microtubules and the promotion ...
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