- Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I
[作者:Kruse, M; Schulze-Bahr, E; Corfield, V; Beckmann, A; Stallmeyer, B; Kurtbay, G; Ohmert, I; Schulze-Bahr, E; Brink, P; Pongs, O,期刊:Journal of clinical investigation, 页码:2737-2744 , 文章类型: Article,,卷期:2009年119-9]
- Progressive familial heart block type I (PFHBI) is a progressive cardiac bundle branch disease in the His-Purkinje system that exhibits autosomal-dominant inheritance. In 3 branches of a large South African Afrikaner ped...
- Extracellular K+ concentration controls cell surface density of I-Kr in rabbit hearts and of the HERG channel in human cell lines
[作者:Guo, J; Massaeli, H; Xu, JM; Jia, ZC; Wigle, JT; Mesaeli, N; Zhang, ST,期刊:Journal of clinical investigation, 页码:2745-2757 , 文章类型: Article,,卷期:2009年119-9]
- Although the modulation of ion channel gating by hormones and drugs has been extensively studied, much less is known about how cell surface ion channel expression levels are regulated. Here, we demonstrate that the cell ...
- Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
[作者:Sundaresan, NR; Gupta, M; Kim, G; Rajamohan, SB; Isbatan, A; Gupta, MP,期刊:Journal of clinical investigation, 页码:2758-2771 , 文章类型: Article,,卷期:2009年119-9]
- Sirtuin 3 (SIRT3) is a member of the sirtuin family of proteins that promote longevity in many organisms. increased expression of SIRT3 has been linked to an extended life span in humans. Here, we have shown that Sirt3 p...
- MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
[作者:Callis, TE; Pandya, K; Seok, HY; Tang, RH; Tatsuguchi, M; Huang, ZP; Chen, JF; Deng, ZL; Gunn, B; Shumate, J; Willis, MS; Selzman, CH; Wang, DZ,期刊:Journal of clinical investigation, 页码:2772-2786 , 文章类型: Article,,卷期:2009年119-9]
- MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Here, we investigated the function and molecular mechanisms of the miR-208 family of miRNAs in ad...
- Transfusion of minor histocompatibility antigen-mismatched platelets induces rejection of bone marrow transplants in mice
[作者:Patel, SR; Cadwell, CM; Medford, A; Zimring, JC,期刊:Journal of clinical investigation, 页码:2787-2794 , 文章类型: Article,,卷期:2009年119-9]
- Bone marrow transplantation (BMT) represents a cure for nonmalignant hematological disorders. However, compared with the stringent conditioning regimens used when performing BMT to treat hematological malignancies, the r...
- A role for pericytes as microenvironmental regulators of human skin tissue regeneration
[作者:Paquet-Fifield, S; Schluter, H; Li, A; Aitken, T; Gangatirkar, P; Blashki, D; Koelmeyer, R; Pouliot, N; Palatsides, M; Ellis, S; Brouard, N; Zannettino, A; Saunders, N; Thompson, N; Li, J; Kaur, P,期刊:Journal of clinical investigation, 页码:2795-2806 , 文章类型: Article,,卷期:2009年119-9]
- The cellular and molecular microenvironment of epithelial stem and progenitor cells is poorly characterized despite well-documented roles in homeostatic tissue renewal, wound healing, and cancer progression. Here, we dem...
- The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts
[作者:Yoshizawa, T; Hinoi, E; Jung, DY; Kajimura, D; Ferron, M; Seo, J; Graff, JM; Kim, JK; Karsenty, G,期刊:Journal of clinical investigation, 页码:2807-2817 , 文章类型: Article,,卷期:2009年119-9]
- The recent demonstration that osteoblasts have a role in controlling energy metabolism suggests that they express cell-specific regulatory genes involved in this process. Activating transcription factor 4 (ATF4) is a tra...
- Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth
[作者:Soman, NR; Baldwin, SL; Hu, G; Marsh, JN; Lanza, GM; Heuser, JE; Arbeit, JM; Wickline, SA; Schlesinger, PH,期刊:Journal of clinical investigation, 页码:2830-2842 , 文章类型: Article,,卷期:2009年119-9]
- The in vivo application of cytolytic peptides for cancer therapeutics is hampered by toxicity, nonspecificity, and degradation. We previously developed a specific strategy to synthesize a nanoscale delivery vehicle for c...
- CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope (vol 118, pg 3390, 2008)
[作者:Skowera, A; Ellis, RJ; Varela-Calvino, R; Arif, S; Huang, GC; Van-Krinks, C; Zaremba, A; Rackham, C; Allen, JS; Tree, TIM; Zhao, M; Dayan, CM; Sewell, AK; Unger, WW; Drijfhout, JW; Ossendorp, F; Roep, BO; Peakman, M,期刊:Journal of clinical investigation, 页码:2843-2843 , 文章类型: Correction,,卷期:2009年119-9]
-
|