- Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models
[作者：Maione, F; Molla, F; Meda, C; Latini, R; Zentilin, L; Giacca, M; Seano, G; Serini, G; Bussolino, F; Giraudo, E,期刊：Journal of clinical investigation, 页码：3356-3372 , 文章类型： Article，,卷期：2009年119-11]
- Tumor growth and progression rely upon angiogenesis, which is regulated by pro- and antiangiogenic factors, including members of the semaphorin family. By analyzing 3 different mouse models of multistep carcinogenesis, w...
- The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice
[作者：Weidemann, A; Kerdiles, YM; Knaup, KX; Rafie, CA; Boutin, AT; Stockmann, C; Takeda, N; Scadeng, M; Shih, AY; Haase, VH; Simon, MC; Kleinfeld, D; Johnson, RS,期刊：Journal of clinical investigation, 页码：3373-3383 , 文章类型： Article，,卷期：2009年119-11]
- A key adaptation to environmental hypoxia. is an increase in erythropoiesis, driven by the hormone erythropoietin (EPO) through what is traditionally thought to be primarily a renal response. However, both neurons and as...
- Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis
[作者：Jacovina, AT; Deora, AB; Ling, Q; Broekman, MJ; Almeida, D; Greenberg, CB; Marcus, AJ; Smith, JD; Hajjar, KA,期刊：Journal of clinical investigation, 页码：3384-3394 , 文章类型： Article，,卷期：2009年119-11]
- When plasma levels of homocysteine (HC), a thiol amino acid formed upon methionine demethylation, exceed 12 mu M, individuals are at increased risk of developing large vessel atherothrombosis and small vessel dysfunction...
- Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
[作者：Taylor, JG; Cheuk, AT; Tsang, PS; Chung, JY; Song, YK; Desai, K; Yu, YL; Chen, QR; Shah, K; Youngblood, V; Fang, J; Kim, SY; Yeung, C; Helman, LJ; Mendoza, A; Ngo, V; Staudt, LM; Wei, JS; Khanna, C; Catchpoole, D; Qualman, SJ; Hewitt, SM; Merlino, G; Chanock, SJ; Khan, J,期刊：Journal of clinical investigation, 页码：3395-3407 , 文章类型： Article，,卷期：2009年119-11]
- Rhabdomyosarcoma (RMS) is a childhood cancer originating from skeletal muscle, and patient survival is poor in the presence of metastatic disease. Few determinants that regulate metastasis development have been identifie...
- Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation
[作者：Bornstein, S; White, R; Malkoski, S; Oka, M; Han, GW; Cleaver, T; Reh, D; Andersen, P; Gross, N; Olson, S; Deng, CX; Lu, SL; Wang, XJ,期刊：Journal of clinical investigation, 页码：3408-3419 , 文章类型： Article，,卷期：2009年119-11]
- Smad4 is a central mediator of TGF-beta signaling, and its expression is downregulated or lost at the malignant stage in several cancer types. In this study, we found that Smad4 was frequently downregulated not only in h...
- Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers
[作者：Levin, MD; Lu, MM; Petrenko, NB; Hawkins, BJ; Gupta, TH; Lang, D; Buckley, PT; Jochems, J; Liu, F; Spurney, CF; Yuan, LJ; Jacobson, JT; Brown, CB; Huang, L; Beermann, F; Margulies, KB; Madesh, M; Eberwine, JH; Epstein, JA; Patel, VV,期刊：Journal of clinical investigation, 页码：3420-3436 , 文章类型： Article，,卷期：2009年119-11]
- Atrial fibrillation is the most common clinical cardiac arrhythmia. It is often initiated by ectopic beats arising from the pulmonary veins and atrium, but the source and mechanism of these beats remains unclear. The mel...
- Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
[作者：Zhong, ZH; Ilieva, H; Hallagan, L; Bell, R; Singh, I; Paquette, N; Thiyagarajan, M; Deane, R; Fernandez, JA; Lane, S; Zlokovic, AB; Liu, T; Griffin, JH; Chow, N; Castellino, FJ; Stojanovic, K; Cleveland, DW; Zlokovic, BV,期刊：Journal of clinical investigation, 页码：3437-3449 , 文章类型： Article，,卷期：2009年119-11]
- Activated protein C (APC) is a signaling protease with anticoagulant activity. Here, we have used mice expressing a mutation in superoxide dismutase-1 (SOD1) that is linked to amyotrophic lateral sclerosis (ALS) to show ...
- Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
[作者：Looney, MR; Nguyen, JX; Hu, YM; Van Ziffle, JA; Lowell, CA; Matthay, MA,期刊：Journal of clinical investigation, 页码：3450-3461 , 文章类型： Article，,卷期：2009年119-11]
- Transfusion-related acute lung injury (TRA-LI) is the leading cause of transfusion-associated mortality in the US. Previously, we established an immune-mediated TRALI mouse model, wherein mice with cognate antigen were c...
- The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization
[作者：Shen, Q; Little, SC; Xu, MQ; Haupt, J; Ast, C; Katagiri, T; Mundlos, S; Seemann, P; Kaplan, FS; Mullins, MC; Shore, EM,期刊：Journal of clinical investigation, 页码：3462-3472 , 文章类型： Article，,卷期：2009年119-11]
- Patients with classic fibrodysplasia ossificans progressiva, a disorder characterized by extensive extraskeletal endochondral bone formation, share a recurrent mutation (R206H) within the glycine/serine-rich domain of AC...
- Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation
[作者：Yang, HC; Xing, SF; Shan, L; O'Connell, K; Dinoso, J; Shen, AD; Zhou, Y; Shrum, CK; Han, YF; Liu, JO; Zhang, H; Margolick, JB; Siliciano, RF,期刊：Journal of clinical investigation, 页码：3473-3486 , 文章类型： Article，,卷期：2009年119-11]
- The development of highly active antiretroviral therapy (HAART) to treat individuals infected with HIV-1 has dramatically improved patient outcomes, but HAART still fails to cure the infection. The latent viral reservoir...
- Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia
[作者：Park, SO; Wankhede, M; Lee, YJ; Choi, EJ; Fliess, N; Choe, SW; Oh, SH; Walter, G; Raizada, MK; Sorg, BS; Oh, SP,期刊：Journal of clinical investigation, 页码：3487-3496 , 文章类型： Article，,卷期：2009年119-11]
- Arteriovenous malformations (AVMs) are vascular anomahes where arteries and veins are directly connected through a complex, tangled web of abnormal arteries and veins instead of a normal capillary network. AVMs in the br...
- The APCs of neuroprotection
[作者：Esmon, CT; Glass, JD,期刊：Journal of clinical investigation, 页码：3205-3208 , 文章类型： Editorial Material，,卷期：2009年119-11]
- Mutations in the enzyme superoxide dismutase 1 (SOD1) have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). In this issue of the JCI, Zhong et al. report that the endogenous anticoagulant...
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