- Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells
[作者：Ivanov, A; Beers, SA; Walshe, CA; Honeychurch, J; Alduaij, W; Cox, KL; Potter, KN; Murray, S; Chan, CHT; Klymenko, T; Erenpreisa, J; Glennie, MJ; Illidge, TM; Cragg, MS,期刊：Journal of clinical investigation, 页码：2143-2159 , 文章类型： Article，,卷期：2009年119-8]
- mAbs are becoming increasingly utilized in the treatment of lymphoid disorders. Although Fc-Fc gamma R interactions are thought to account for much of their therapeutic effect, this does not explain why certain mAb speci...
- HIF2 alpha cooperates with RAS to promote lung tumorigenesis in mice
[作者：Kim, WY; Perera, S; Zhou, B; Carretero, J; Yeh, JJ; Heathcote, SA; Jackson, AL; Nikolinakos, P; Ospina, B; Naumov, G; Brandstetter, KA; Weigman, VJ; Zaghlul, S; Hayes, DN; Padera, RF; Heymach, JV; Kung, AL; Sharpless, NE; Kaelin, WG; Wong, KK,期刊：Journal of clinical investigation, 页码：2160-2170 , 文章类型： Article，,卷期：2009年119-8]
- Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia. In non-small cell lung cancer (NSCLC), high HIF2 alpha levels correlate with decreased overall surv...
- RCP is a human breast cancer-promoting gene with Ras-activating function
[作者：Zhang, JQ; Liu, XJ; Datta, A; Govindarajan, K; Tam, WL; Han, JY; George, J; Wong, C; Ramnarayanan, K; Phua, TY; Leong, WY; Chan, YS; Palanisamy, N; Liu, ETB; Karuturi, KM; Lim, B; Miller, LD,期刊：Journal of clinical investigation, 页码：2171-2183 , 文章类型： Article，,卷期：2009年119-8]
- Aggressive forms of cancer are often defined by recurrent chromosomal alterations, yet in most cases, the causal or contributing genetic components remain poorly understood. Here, we utilized microarray informatics to id...
- The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8(+) T cells
[作者：Ruder, C; Hopken, UE; Wolf, J; Mittrucker, HW; Engels, B; Erdmann, B; Wollenzin, S; Uckert, W; Dorken, B; Rehm, A,期刊：Journal of clinical investigation, 页码：2184-2203 , 文章类型： Article，,卷期：2009年119-8]
- CTLs eliminate virus-infected and tumorigenic cells through exocytosis of cytotoxic agents from lytic granules. While insights into the intracellular mechanisms facilitating lytic granule release have been obtained throu...
- Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice
[作者：Matsuura, K; Honda, A; Nagai, T; Fukushima, N; Iwanaga, K; Tokunaga, M; Shimizu, T; Okano, T; Kasanuki, H; Hagiwara, N; Komuro, I,期刊：Journal of clinical investigation, 页码：2204-2217 , 文章类型： Article，,卷期：2009年119-8]
- Cardiac progenitor cells are a potential source of cell therapy for heart failure. Although recent studies have shown that transplantation of cardiac stem/progenitor cells improves function of infarcted hearts, the preci...
- Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity
[作者：Cubillos-Ruiz, JR; Engle, X; Scarlett, UK; Martinez, D; Barber, A; Elgueta, R; Wang, L; Nesbeth, Y; Durant, Y; Gewirtz, AT; Sentman, CL; Kedl, R; Conejo-Garcia, JR,期刊：Journal of clinical investigation, 页码：2231-2244 , 文章类型： Article，,卷期：2009年119-8]
- The success of clinically relevant immunotherapies requires reversing tumor-induced immunosuppression. Here we demonstrated that linear polyethylenimine-based (PEI-based) nanoparticles encapsulating siRNA were preferenti...
- Identification of heme oxygenase-1-specific regulatory CD8(+) T cells in cancer patients
[作者：Andersen, MH; Sorensen, RB; Brimnes, MK; Svane, IM; Becker, JC; Straten, PT,期刊：Journal of clinical investigation, 页码：2245-2256 , 文章类型： Article，,卷期：2009年119-8]
- Treg deficiencies are associated with autoimmunity. Conversely, CD4(+) and CD8(+) Tregs accumulate in the tumor microenviromnent and are associated with prevention of antitumor immunity and anticancer immunotherapy. Rece...
- The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice
[作者：Minami, T; Yano, K; Miura, M; Kobayashi, M; Suehiro, J; Reid, PC; Hamakubo, T; Ryeom, S; Aird, WC; Kodama, T,期刊：Journal of clinical investigation, 页码：2257-2270 , 文章类型： Article，,卷期：2009年119-8]
- Down syndrome critical region gene 1 (DSCR-1) short variant (DSCR-1s) is an inhibitor of calcineurin/NFAT signaling encoded by exons 4-7 of DSCR1. We previously reported that VEGF induces DSCR-1s expression in endothelia...
- Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs
[作者：Boretti, FS; Buehler, PW; D'Agnillo, F; Kluge, K; Glaus, T; Butt, OI; Jia, YP; Goede, J; Pereira, CP; Maggiorini, M; Schoedon, G; Alayash, AI; Schaer, DJ,期刊：Journal of clinical investigation, 页码：2271-2280 , 文章类型： Article，,卷期：2009年119-8]
- Release of hemoglobin (Hb) into the circulation is a central pathophysiologic event that contributes to morbidity and mortality in chronic hemolytic anemias and severe malaria. These toxicities arise from Hb-mediated vas...
- Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia
[作者：Shivakumar, P; Sabla, GE; Whitington, P; Chougnet, CA; Bezerra, JA,期刊：Journal of clinical investigation, 页码：2281-2290 , 文章类型： Article，,卷期：2009年119-8]
- Biliary atresia is a neonatal obstructive cholangiopathy that progresses to end-stage liver disease. Although the etiology is unknown, a neonatal adaptive immune signature has been mechanistically linked to obstruction o...
- Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents
[作者：Wallingford, N; Perroud, B; Gao, Q; Coppola, A; Gyengesi, E; Liu, ZW; Gao, XB; Diament, A; Haus, KA; Shariat-Madar, Z; Mahdi, F; Wardlaw, SL; Schmaier, AH; Warden, CH; Diano, S,期刊：Journal of clinical investigation, 页码：2291-2303 , 文章类型： Article，,卷期：2009年119-8]
- The anorexigenic neuromodulator alpha-melanocyte-stimulating hormone (alpha-MSH; referred to here as alpha-MSH1-13) undergoes extensive posttranslational processing, and its in vivo activity is short lived due to rapid i...
- A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice
[作者：He, SQ; Atkinson, C; Qiao, F; Cianflone, K; Chen, XP; Tomlinson, S,期刊：Journal of clinical investigation, 页码：2304-2316 , 文章类型： Article，,卷期：2009年119-8]
- Massive liver resection and small-for-size liver transplantation pose a therapeutic challenge, due to increased susceptibility of the remnant/graft to ischemia reperfusion injury (IRI) and impaired regeneration. We inves...
- CCR6 is required for IL-23-induced psoriasis-like inflammation in mice
[作者：Hedrick, MN; Lonsdorf, AS; Shirakawa, AK; Lee, CCR; Liao, F; Singh, SP; Zhang, HWH; Grinberg, A; Love, PE; Hwang, ST; Farber, JM,期刊：Journal of clinical investigation, 页码：2317-2329 , 文章类型： Article，,卷期：2009年119-8]
- Psoriasis is a common immune-mediated chronic inflammatory skin disorder, but the mechanisms of pathogenesis are still poorly understood. IL-23 is expressed in psoriatic skin, and IL-23 injection produces IL-22-dependent...
- CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice
[作者：Menke, J; Iwata, Y; Rabacal, WA; Basu, R; Yeung, YG; Humphreys, BD; Wada, T; Schwarting, A; Stanley, ER; Kelley, VR,期刊：Journal of clinical investigation, 页码：2330-2342 , 文章类型： Article，,卷期：2009年119-8]
- Tubular damage following ischemic renal injury is often reversible, and tubular epithelial cell (TEC) proliferation is a hallmark of tubular repair. Macrophages have been implicated in tissue repair, and CSF-1, the princ...
- Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells
[作者：Alvarez-Diaz, S; Valle, N; Garcia, JM; Pena, C; Freije, JMP; Quesada, V; Astudillo, A; Bonilla, F; Lopez-Otin, C; Munoz, A,期刊：Journal of clinical investigation, 页码：2343-2358 , 文章类型： Article，,卷期：2009年119-8]
- The active vitamin D metabolite 1 alpha,25-dihydroxyvitamin D-3 [1 alpha,25(OH)(2)D-3] has wide but not fully understood antitumor activity. A previous transcriptomic analysis of 1 alpha,25(OH)(2)D-3 action on human colo...
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