- Insulin exocytosis in Goto-Kakizaki rat beta-cells subjected to long-term glinide or sulfonylurea treatment
[作者:Kawai, J; Ohara-Imaizumi, M; Nakamichi, Y; Okamurai, T; Akimoto, Y; Matsushimai, S; Aoyagi, K; Kawakami, H; Watanabe, T; Watada, H; Kawamori, R; Nagamatsu, S,期刊:Biochemical Journal, 页码:93-101 , 文章类型: Article,,卷期:2008年412-1]
- Sulfonylurea and glinide drugs display different effects on insulin granule motion in single beta-cells in vitro. We therefore investigated the different effects that these drugs manifest towards insulin release in an in...
- Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E-2 release via C/EBP beta in human bronchial epithelial cells
[作者:He, DH; Natarajan, V; Stern, R; Gorshkova, IA; Solway, J; Spannhake, EW; Zhao, YT,期刊:Biochemical Journal, 页码:153-162 , 文章类型: Article,,卷期:2008年412-1]
- We have demonstrated that LPA (lysophosphatidic acid)induced IL (interleukin)-8 secretion was partly mediated via transactivation of EGFR [EGF (epidermal growth factor) receptor] in HBEpCs (human bronchial epithelial pri...
- Intracellular copper deficiency increases amyloid-ss secretion by diverse mechanisms
[作者:Cater, MA; McInnes, KT; Li, QX; Volitakis, I; La Fontaine, S; Mercer, JFB; Bush, AI,期刊:Biochemical Journal, 页码:141-152 , 文章类型: Article,,卷期:2008年412-1]
- In Alzheimer's disease there is abnormal brain copper distribution, with accumulation of copper in amyloid plaques and a deficiency of copper in neighbouring cells. Excess copper inhibits A (amyloid-peptide) production, ...
- Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release
[作者:Jones, PP; Jiang, DW; Bolstad, J; Hunt, DJ; Zhang, L; Demaurex, N; Chen, SRW,期刊:Biochemical Journal, 页码:171-178 , 文章类型: Article,,卷期:2008年412-1]
- A number of RyR2 (cardiac ryanodine receptor) mutations linked to ventricular arrhythmia and sudden death are located within the last C-terminal similar to 500 amino acid residues, which is believed to constitute the ion...
- Calsenilin and CALP interact with the cytoplasmic tail of UDP-Gal: GA2/GM2/GD2 beta-1,3-galactosyltransferase
[作者:Quintero, CA; Valdez-Taubas, J; Ferrari, ML; Haedo, SD; Maccioni, HJF,期刊:Biochemical Journal, 页码:19-26 , 文章类型: Article,,卷期:2008年412-1]
- GalT2 (UDP-Gal:GA2/GM2/GD2 beta-1,3-galactosyltransferase) is a Golgi-resident type 11 membrane protein that participates in the synthesis of glycosphingolipids. The molecular determinants for traffic and localization of...
- Site-directed mulagenesis of firefly luciferase: implication of conserved residue(s) in bioluminescence emission spectra among firefly luciferases
[作者:Tafreshi, NK; Sadeghizadehi, M; Emamzadeh, R; Rawbar, B; Naderi-Manesh, H; Hosseinkhani, S,期刊:Biochemical Journal, 页码:27-33 , 文章类型: Article,,卷期:2008年412-1]
- The bioluminescence colours of firefly luciferases are determined by assay conditions and luciferase structure. Owing to red light having lower energy than green light and being less absorbed by biological tissues, red-e...
- N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)
[作者:He, YW; Ramsay, AJ; Hunt, ML; Whitbread, AK; Myers, SA; Hooper, JD,期刊:Biochemical Journal, 页码:45-55 , 文章类型: Article,,卷期:2008年412-1]
- The Tweety proteins are a family of recently identified putative Cl- channels predicted to be modified by N-glycosylation and, controversially, to contain five or six membrane-spanning domains, leading to the contentious...
- DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites
[作者:Jagelska, EB; Brazda, V; Pecinka, P; Palecek, E; Fojta, M,期刊:Biochemical Journal, 页码:57-63 , 文章类型: Article,,卷期:2008年412-1]
- The tumour suppressor protein p53 is one of the most important factors regulating cell proliferation, differentiation and programmed cell death in response to a variety of cellular stress signals. P53 is a nuclear phosph...
- Prostaglndin E1 inhibits IL-6-induced MCM expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation
[作者:Sobota, RM; Muller, PJ; Heinrich, PC; Schaper, F,期刊:Biochemical Journal, 页码:65-72 , 文章类型: Article,,卷期:2008年412-1]
- IL (interleukin)-6 exerts pro- as well as anti-inflammatory activities. Beside many other activities, IL-6 is the major inducer of acute phase proteins in the liver, acts as a differentiation factor for blood cells, as m...
- The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant
[作者:Trotter, EW; Rand, JD; Vickerstaff, J; Grant, CM,期刊:Biochemical Journal, 页码:73-80 , 文章类型: Article,,卷期:2008年412-1]
- The yeast Tsa1 peroxiredoxin, like other 2-Cys peroxiredoxins, has dual activities as a peroxidase and as a molecular chaperone. Its peroxidase function predominates in lower-molecular-mass forms, whereas a super-chapero...
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