个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共26条记录   An Oxygen-Sensing Diguanylate Cyclase and Phosphodiesterase Couple for c-di-GMP Control [作者：Tuckerman, JR; Gonzalez, G; Sousa, EHS; Wan, XH; Saito, JA; Alam, M; Gilles-Gonzalez, MA,期刊：Biochemistry, 页码：9764-9774 , 文章类型： Article，,卷期：2009年48-41] A commonly observed coupling of sensory domains to GGDEF-class diguanylate cyclases and EAL-class phosphodiesterases has long suggested that c-di-GMP synthesizing and degrading enzyme sense environmental signals. Neverth... Novel Binding Motif of ACTH Analogues at the Melanocortin Receptors [作者：Yang, YK; Hruby, VJ; Chen, M; Crasto, C; Cai, MY; Harmon, CM,期刊：Biochemistry, 页码：9775-9784 , 文章类型： Article，,卷期：2009年48-41] The melanocortin receptor (MCR) subtype family is a member of the GPCR superfamily, and each of them has a different pharmacological profile with regard to the relative potency of the endoganous and synthetic melanocorti... Anopheles gambiae Alkaline Phosphatase Is a Functional Receptor of Bacillus thuringiensis jegathesan Cry11Ba Toxin [作者：Hua, G; Zhang, R; Bayyareddy, K; Adang, MJ,期刊：Biochemistry, 页码：9785-9793 , 文章类型： Article，,卷期：2009年48-41] Alkaline phosphatases (ALPs, EC 3131) isolated from lepidopteran and dipteran species are identified as receptors for Cry1Ac an Cry11Aa toxins, respectively [Jurat-Fuentes, J. L., and Adang, M.J. (2004) Eur. J. Biochem. ... Biochemical Characterization of the Multidrug Regulator QacR Distinguishes Residues That Are Crucial to Multidrug Binding and Induction of qacA Transcription [作者：Peters, KM; Sharbeen, G; Theis, T; Skurray, RA; Brown, MH,期刊：Biochemistry, 页码：9794-9800 , 文章类型： Article，,卷期：2009年48-41] Slaphylococcus aureus transcription factor QacR regulates expression of the qacA multidrug efflux determinant. In response to binding cationic lipophilic compounds, including ethidium and rhodamine 60, QacR dissociates f... Disruption of the Proton Relay Network in the Class 2 Dihydroorotate Dehydrogenase from Escherichia coli [作者：Kow, RL; Whicher, JR; McDonald, CA; Palfey, BA; Fagan, RL,期刊：Biochemistry, 页码：9801-9809 , 文章类型： Article，,卷期：2009年48-41] Dihydroorotate dehydrogenases (DHODs) are FMN-containing enzymes that catalyze the conversion of dihydroorotate (DHO) to orotate in the de novo synthesis of pyrimidines. During the reaction, a proton is transferred from ... Structure and Inhibition of Human Diamine Oxidase [作者：McGrath, AP; Hilmer, KM; Collyer, CA; Shepard, EM; Elmore, BO; Brown, DE; Dooley, DM; Guss, JM,期刊：Biochemistry, 页码：9810-9822 , 文章类型： Article，,卷期：2009年48-41] Humans have three functioning genes that encode copper-containing amine oxidases. The product of the AOC1 gene is a so-called diamine oxidase (hDAO), named for its substrate preference for diamines, particularly histamin... Characterization of the CHK1 Allosteric Inhibitor Binding Site [作者：Vanderpool, D; Johnson, TO; Ping, C; Bergqvist, S; Alton, G; Phonephaly, S; Rui, E; Luo, C; Deng, YL; Grant, S; Quenzer, T; Margosiak, S; Register, J; Brown, E; Ermolieff, J,期刊：Biochemistry, 页码：9823-9830 , 文章类型： Article，,卷期：2009年48-41] Checkpoint kinase 1 (CHK1) is a key element in the DNA damage response pathway and plays a crucial role in the S-G(2)-phase checkpoint, Inhibiting CHK1 is a therapeutic strategy involving abrogation of the G2/M mitotic c... Lipidic Sponge Phase Crystal Structure of a Photosynthetic Reaction Center Reveals Lipids on the Protein Surface [作者：Wohri, AB; Wahlgren, WY; Malmerberg, E; Johansson, LC; Neutze, R; Katona, G,期刊：Biochemistry, 页码：9831-9838 , 文章类型： Article，,卷期：2009年48-41] Membrane proteins are embedded in a lipid bilayer and maintain strong interactions with lipid molecules, Tightly bound lipids are responsible for vertical positioning and integration of proteins in the membrane and for a... Matrix Metalloproteinase 2 Inhibition: Combined Quantum Mechanics and Molecular Mechanics Studies of the Inhibition Mechanism of (4-Phenoxyphenylsulfonyl)methylthiirane and Its Oxirane Analogue [作者：Tao, P; Fisher, JF; Shi, QC; Vreven, T; Mobashery, S; Schlegel, HB,期刊：Biochemistry, 页码：9839-9847 , 文章类型： Article，,卷期：2009年48-41] The inhibition mechanism of matrix metalloproteinase 2 (MMP2) by the selective inhibitor (4-phenoxyphenylsulfonyl)methylthiirane (SB-3CT) and its oxirane analogue is investigated computationally. The inhibition mechanism... Effects of pH on the Rieske Protein from Thermus thermophilus: A Spectroscopic and Structural Analysis [作者：Konkle, ME; Muellner, SK; Schwander, AL; Dious, MM; Pokhrel, R; Britt, RD; Taylor, AB; Hunsicker-Wang, LM,期刊：Biochemistry, 页码：9848-9857 , 文章类型： Article，,卷期：2009年48-41] The Rieske protein from Thermus, thermophilus (TtRp) and a truncated version OF the protein (truncTtRp), produced to achieve a low-pH crystallization condition, have been characterized using UV-visible and circular dichr... A New Class of Isothiocyanate-Based Irreversible Inhibitors of Macrophage Migration Inhibitory Factor [作者：Ouertatani-Sakouhi, H; El-Turk, F; Fauvet, B; Roger, T; Le Roy, D; Karpinar, DP; Leng, L; Bucala, R; Zweckstetter, M; Calandra, T; Lashuel, HA,期刊：Biochemistry, 页码：9858-9870 , 文章类型： Article，,卷期：2009年48-41] Macrophage migration inhibitory factor (MIF) is a homotrimerte multifunctional proinflammatrory cytokine that has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. Current therapeutic s... Copper Binding to beta-2-Microglobulin and Its Pre-Amyloid Oligomer [作者：Srikanth, R; Mendoza, VL; Bridgewater, JD; Zhang, GS; Vachet, RW,期刊：Biochemistry, 页码：9871-9881 , 文章类型： Article，,卷期：2009年48-41] beta-2-Microglobulin (beta 2m) deposits as amyloid fibrils in the musculoskeletal system of patients undergoing long-term dialysis treatment as a result of kidney failure. Previous work has shown that Cu(II) binding paus... Correctors Enhance Maturation of Delta F508 CFTR by Promoting Interactions between the Two Halves of the Molecule [作者：Loo, TW; Bartlett, MC; Clarke, DM,期刊：Biochemistry, 页码：9882-9890 , 文章类型： Article，,卷期：2009年48-41] Deletion or Phe508 in cystic fibrosis transmembrane conductance regulator (Delta F508 CFTR) causes cystic fibrosis. CFTR consists of two homologous halves with each containing 4 nucleotide-binding domain (NBD) and a tran... Structural Insights into Glucan Phosphatase Dynamics Using Amide Hydrogen-Deuterium Exchange Mass Spectrometry [作者：Hsu, S; Kim, Y; Li, S; Durrant, ES; Pace, RM; Woods, VL; Gentry, MS,期刊：Biochemistry, 页码：9891-9902 , 文章类型： Article，,卷期：2009年48-41] Laforin an(l starch excess 4 (SEX4) are founding members of it class of phosphatases that dephosphorylate phosphoglucans. Each protein contains a carbohydrate binding module (CBM) and a dual specificity phosphatase (DSP)... Real Time Monitoring of Sickle Cell Hemoglobin Fiber Formation by UV Resonance Raman Spectroscopy [作者：Knee, KM; Mukerji, I,期刊：Biochemistry, 页码：9903-9911 , 文章类型： Article，,卷期：2009年48-41] In sickle cell hemoglobin, individual tetramers associate into long fibers as a consequence of the mutation at the 6 position. In this study UV resonance Ranan spectroscopy is used to monitor the formation of Hb S fibers... Why the Extended-Spectrum beta-Lactamases SHV-2 and SHV-5 Are "Hypersusceptible" to Mechanism-Based Inhibitors [作者：Kalp, M; Bethel, CR; Bonomo, RA; Carey, PR,期刊：Biochemistry, 页码：9912-9920 , 文章类型： Article，,卷期：2009年48-41] Extended-spectrum beta-lactamases (ESBLs) are derivatives of enzymes such as SHV-1 and TEM-1 that have undergone site-specific mutations that enable them to hydrolyze, and thus inactivate, oxyimino-cephalosporins, such a...