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  • Helix Formation in Arrestin Accompanies Recognition of Photoactivated Rhodopsin
    [作者:Feuerstein, SE; Pulvermuller, A; Hartmann, R; Granzin, J; Stoldt, M; Henklein, P; Ernst, OP; Heck, M; Willbold, D; Koenig, BW,期刊:Biochemistry, 页码:10733-10742 , 文章类型: Article,,卷期:2009年48-45]
  • Binding of arrestin to photoactivated phosphorylated rhodopsin terminates the amplification of visual signals in photoreceptor cells. Currently, there is no crystal structure of a rhodopsin-arrestin complex available, al...
  • Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays
    [作者:Godemann, R; Madden, J; Kramer, J; Smith, M; Fritz, U; Hesterkamp, T; Barker, J; Hoppner, S; Hallett, D; Cesura, A; Ebneth, A; Kemp, J,期刊:Biochemistry, 页码:10743-10751 , 文章类型: Article,,卷期:2009年48-45]
  • Novel nonpeptidic inhibitors of beta-secretase (BACE1) have been discovered by employing a fragment-based biochemical screening approach. A diverse library of 20000 low-molecular weight compounds were screened and yielde...