个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共31条记录   2.6 angstrom X-ray Crystal Structure of Human p53R2, a p53-Inducible Ribonucleotide Reductase [作者：Smith, P; Zhou, BS; Ho, N; Yuan, YC; Su, L; Tsai, SC; Yen, Y,期刊：Biochemistry, 页码：11134-11141 , 文章类型： Article，,卷期：2009年48-46] Human p53R2 (hp53R2) is a 351-residue p53-inducible ribonucleotide reductase (RNR) small subunit. It shares >80% sequence identity with hRRM2, the small RNR subunit responsible for normal maintenance of the deoxyribonucl... Hypochlorous Acid Reacts with the N-Terminal Methionines of Proteins To Give Dehydromethionine, a Potential Biomarker for Neutrophil-Induced Oxidative Stress [作者：Beal, JL; Foster, SB; Ashby, MT,期刊：Biochemistry, 页码：11142-11148 , 文章类型： Article，,卷期：2009年48-46] Electrophilic halogenating agents, including hypohalous acids and haloamines, oxidize free methionine and the N-terminal methionines of peptides and proteins (e.g., Met-1 of anti-inflammatory peptide 1 and ubiquitin) to ... Enterobactin Synthetase-Catalyzed Formation of P-1,P-3-Diadenosine-5 '-tetraphosphate [作者：Sikora, AL; Cahill, SM; Blanchard, JS,期刊：Biochemistry, 页码：10827-10829 , 文章类型： Article，,卷期：2009年48-46] The EntE enzyme, involved in the synthesis of the iron siderophore enterobactin, catalyzes the adenylation of 2,3-dihydroxybenzoic acid, followed by its transfer to the phosphopantetheine arm of holo-EntB, an aryl carrie... Updated Biological Roles for Matrix Metalloproteinases and New "Intracellular" Substrates Revealed by Degradomics [作者：Butler, GS; Overall, CM,期刊：Biochemistry, 页码：10830-10845 , 文章类型： Review，,卷期：2009年48-46] Shotgun proteomics techniques are conceptually unbiased, but data interpretation and follow-Lip experiments are often constrained by dogma, established beliefs that are accepted without question, that can dilute the powe... Universal Convergence of the Specific Volume Changes of Globular Proteins upon Unfolding [作者：Schweiker, KL; Fitz, VW; Makhatadze, GI,期刊：Biochemistry, 页码：10846-10851 , 文章类型： Article，,卷期：2009年48-46] Both pressure and temperature are important environmental variables, and to obtain a complete understanding or the mechanisms of protein folding, it is necessary to determine how protein stability is dependent on these f... H2A.Z and H3.3 Histone Variants Affect Nucleosome Structure: Biochemical and Biophysical Studies [作者：Thakar, A; Gupta, P; Ishibashi, T; Finn, R; Silva-Moreno, B; Uchiyama, S; Fukui, K; Tomschik, M; Ausio, J; Zlatanova, J,期刊：Biochemistry, 页码：10852-10857 , 文章类型： Article，,卷期：2009年48-46] Histone variants play important roles in regulation of chromatin structure and function. To understand the structural role played by historic variants H2A.Z and H3.3, both of which are implicated in transcription regulat... Single-Molecule Analysis of the Human Telomerase RNA center dot Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations [作者：Ashbridge, B; Orte, A; Yeoman, JA; Kirwan, M; Vulliamy, T; Dokal, I; Klenerman, D; Balasubramanian, S,期刊：Biochemistry, 页码：10858-10865 , 文章类型： Article，,卷期：2009年48-46] It has been proposed that human telomerase RNA (hTR) interacts with dyskerin, prior to assembly of the telomerase holoenzyme. The direct interaction of dyskerin and hTR has not been demonstrated and is an experimentally ... Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase [作者：Urban, M; Joubert, N; Hocek, M; Alexander, RE; Kuchta, RD,期刊：Biochemistry, 页码：10866-10881 , 文章类型： Article，,卷期：2009年48-46] Herpes simplex virus-1 primase misincorporates the natural NTPs at frequencies of around one error per 30 NTPs polymerized, making it one of the least accurate polymerases known. We used a series of nucleotide analogues ... Chemical Synthesis of LNA-2-thiouridine and Its Influence on Stability and Selectivity of Oligonucleotide Binding to RNA [作者：Carlucci, M; Kierzek, E; Olejnik, A; Turner, DH; Kierzek, R,期刊：Biochemistry, 页码：10882-10893 , 文章类型： Article，,卷期：2009年48-46] Hybridization to RNA is important for many applications, including antisense therapeutics, RNA interference, and microarray screening. Similar thermodynamic stabilities of A-U and G-U base pairs result in difficulties in... An NSAID-like Compound, FT-9, Preferentially Inhibits gamma-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1 [作者：Frigerio, CS; Kukar, TL; Fauq, A; Engel, PC; Golde, TE; Walsh, DM,期刊：Biochemistry, 页码：10894-10904 , 文章类型： Article，,卷期：2009年48-46] Inhibition of gamma-secretase cleavage of the amyloid precursor protein (APP) is a prime target for the development of therapeutics for treating Alzheimer's disease; however, complete inhibition of this activity would al... Design of Nontoxic Analogues of Cathelicidin-Derived Bovine Antimicrobial Peptide BMAP-27: The Role of Leucine as Well as Phenylalanine Zipper Sequences in Determining Its Toxicity [作者：Ahmad, A; Azmi, S; Srivastava, RM; Srivastava, S; Pandey, BK; Saxena, R; Bajpai, VK; Ghosh, JK,期刊：Biochemistry, 页码：10905-10917 , 文章类型： Article，,卷期：2009年48-46] BMAP-27 is a cathelicidin-derived bovine antimicrobial peptide, which shows moderate cytotoxicity and potent antibacterial activity against a wide variety of microorganisms. Despite a number of studies, very little is kn... Impaired Processing of Human Pro-Islet Amyloid Polypeptide Is Not a Causative Factor for Fibril Formation or Membrane Damage in Vitro [作者：Khemtemourian, L; Casarramona, GL; Suylen, DPL; Hackeng, TM; Meeldijk, JD; de Kruijff, B; Hoppener, JWM; Killian, JA,期刊：Biochemistry, 页码：10918-10925 , 文章类型： Article，,卷期：2009年48-46] Human islet amyloid polypeptide (hIAPP) forms amyloid fibrils in pancreatic islets of patients with type 2 diabetes mellitus (DM2). hIAPP is synthesized by islet beta-cells initially as a preprohormone, processing of whi... PIP2-Binding Site in Kir Channels: Definition by Multiscale Biomolecular Simulations [作者：Stansfeld, PJ; Hopkinson, R; Ashcroft, FM; Sansom, MSP,期刊：Biochemistry, 页码：10926-10933 , 文章类型： Article，,卷期：2009年48-46] Phosphatidylinositol bisphosphate (PIP2) is an activator of mammalian inwardly rectifying potassium (Kir) channels. Multiscale simulations, via a sequential combination of coarse-grained and atomistic molecular dynamics,... Denaturant-Dependent Conformational Changes in a beta-Trefoil Protein: Global and Residue-Specific Aspects of an Equilibrium Denaturation Process [作者：Latypov, RF; Liu, DJ; Jacob, J; Harvey, TS; Bondarenko, PV; Kleemann, GR; Brems, DN; Raibekas, AA,期刊：Biochemistry, 页码：10934-10947 , 文章类型： Article，,卷期：2009年48-46] Conformational properties of the folded and unfolded ensembles of human interleukin-1 receptor antagonist (IL-1ra) are strongly denaturant-dependent as evidenced by high-resolution two-dimensional nuclear magnetic resona... Reconstitution of Gloeobacter violaceus Rhodopsin with a Light-Harvesting Carotenoid Antenna [作者：Imasheva, ES; Balashov, SP; Choi, AR; Jung, KH; Lanyi, JK,期刊：Biochemistry, 页码：10948-10955 , 文章类型： Article，,卷期：2009年48-46] We show that salinixanthin, the light-harvesting carotenoid antenna of xanthorhodopsin, can be reconstituted into the retinal protein from Gloeobacter violaceus expressed in Escherichia coli. Reconstitution of gloeobacte... Reengineering the Signaling Properties of a Src Family Kinase [作者：Yadav, SS; Yeh, BJ; Craddock, BP; Lim, WA; Miller, WT,期刊：Biochemistry, 页码：10956-10962 , 文章类型： Article，,卷期：2009年48-46] Src family kinases (SFKs) are modular signaling proteins possessing SH3, SH2, and tyrosine kinase domains. The SH3 and SH2 domains of SFKs have dual roles: they regulate the activity of the kinases, and they also target ...