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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   A20 is overexpressed in glioma cells and may serve as a potential therapeutic target [作者：Guo, QD; Dong, H; Liu, XN; Wang, CM; Liu, NN; Zhang, JN; Li, B; Cao, WD; Ding, TB; Yang, ZY; Zhang, X,期刊：Expert Opinion on Therapeutic Targets, 页码：733-741 , 文章类型： Article，,卷期：2009年13-7] Objective: A20 is a TNF-inducible primary response gene, which has been found to have antiapoptotic function in several cancer cells. This study investigates A20 expression in human glioma tissues and four glioma cell li... Atorvastatin affects low density lipoprotein and non-high density lipoprotein cholesterol relations with apolipoprotein B in type 2 diabetes mellitus: modification by triglycerides and cholesteryl ester transfer protein [作者：Kappelle, PJWH; Zwang, L; Huisman, MV; Banga, JD; Sluiter, WJ; Dallinga-Thie, GM; Dullaart, RPF,期刊：Expert Opinion on Therapeutic Targets, 页码：743-751 , 文章类型： Article，,卷期：2009年13-7] Objectives: Non-HDL-cholesterol (non-HDL-C) and apolipoprotein (apo) B are proposed as treatment targets. The extent to which statin therapy affects relationships of LDL-C and non-HDL-C with apoB was examined in type 2 d... Peptide deformylase - a promising therapeutic target for tuberculosis and antibacterial drug discovery [作者：Sharma, A; Khuller, GK; Sharma, S,期刊：Expert Opinion on Therapeutic Targets, 页码：753-765 , 文章类型： Review，,卷期：2009年13-7] Background: Tuberculosis (TB) remains the most important infectious disease causing morbidity and death, due to the human pathogen Mycobacterium tuberculosis. The emergence of multi-drug-resistant and extensively-drug-re... Targeting histone deacetylases for heart failure [作者：Bush, EW; McKinsey, TA,期刊：Expert Opinion on Therapeutic Targets, 页码：767-784 , 文章类型： Review，,卷期：2009年13-7] Background: Stresses such as chronic hypertension and myocardial infarction can trigger the heart to undergo a remodeling process characterized by myocyte hypertrophy, myocyte death and fibrosis, often resulting in impai... Targeting the Nrf2 pathway against cardiovascular disease [作者：Li, JQ; Ichikawa, T; Janicki, JS; Cui, TX,期刊：Expert Opinion on Therapeutic Targets, 页码：785-794 , 文章类型： Review，,卷期：2009年13-7] Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that controls the basal and inducible expression of a battery of antioxidant genes and other cytoprotective Phase II detoxifying enzymes. Nrf2 is ubiqui... Potential therapeutic targets in obstructive sleep apnoea [作者：Saboisky, JP; Chamberlin, NL; Malhotra, A,期刊：Expert Opinion on Therapeutic Targets, 页码：795-809 , 文章类型： Review，,卷期：2009年13-7] Obstructive sleep apnoea (OSA) is a disease of ever-increasing importance due to its association with multiple impairments and rising prevalence in an increasingly susceptible demographic. The syndrome is linked with lou... EMP3 as a candidate tumor suppressor gene for solid tumors [作者：Fumoto, S; Tanimoto, K; Hiyama, E; Noguchi, T; Nishiyama, M; Hiyama, K,期刊：Expert Opinion on Therapeutic Targets, 页码：811-822 , 文章类型： Review，,卷期：2009年13-7] Background: Epithelial membrane protein 3 (EMP3), was recently reported to be a tumor suppressor gene for several solid tumors, and is drawing attention as a novel prognostic marker, since its expression level or hyperme... Targeting CD133 antigen in cancer [作者：Ferrandina, G; Petrillo, M; Bonanno, G; Scambia, G,期刊：Expert Opinion on Therapeutic Targets, 页码：823-837 , 文章类型： Review，,卷期：2009年13-7] Background: Much attention has been focused on CD133 as a marker of cancer cells with stem-cell-like ability. In the cancer stem cells (CSCs) model, only a small proportion of tumour cells are able to self-renew extensiv... Dickkopf-1: a suitable target for the management of myeloma bone disease [作者：Gavriatopoulou, M; Dimopoulos, MA; Christoulas, D; Migkou, M; Iakovaki, M; Gkotzamanidou, M; Terpos, E,期刊：Expert Opinion on Therapeutic Targets, 页码：839-848 , 文章类型： Review，,卷期：2009年13-7] Bone disease remains a major problem in the management of patients with multiple myeloma (MM) and is characterized by the presence of lytic lesions due to increased osteoclastic activity and reduced osteoblast function. ... Prostaglandin E-2 synthase inhibition as a therapeutic target [作者：Iyer, JP; Srivastava, PK; Dev, R; Dastidar, SG; Ray, A,期刊：Expert Opinion on Therapeutic Targets, 页码：849-865 , 文章类型： Review，,卷期：2009年13-7] Background: Most NSAIDs function by inhibiting biosynthesis of PGE(2) by inhibition of COX-1 and/or COX-2. Since COX-1 has a protective function in the gastro-intestinal tract (GIT), non-selective inhibition of both cycl... Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models [作者：Kapitulnik, J; Pelkonen, O; Gundert-Remy, U; Dahl, SG; Boobis, AR,期刊：Expert Opinion on Therapeutic Targets, 页码：867-887 , 文章类型： Review，,卷期：2009年13-7] Biologically active molecules, that is pharmaceuticals and other chemical substances, exert their therapeutic and/or toxic effects by complex interactions with their biological targets/active sites. This review discusses...