- Structure and Function Relationship of Murine Insulin-like Peptide 5 (INSL5): Free C-Terminus Is Essential for RXFP4 Receptor Binding and Activation
[作者:Begi, A; Hossain, MA; Shabanpoor, F; Chan, LD; Zhang, SD; Bathgate, RAD; Tregear, GW; Wade, JD,期刊:Biochemistry, 页码:8352-8361 , 文章类型: Article,,卷期:2011年50-39]
- Insulin-like peptide 5 (INSL5) is a member of insulin/relaxin superfamily of peptides. It has recently been identified as the cognate ligand for the G-protein-coupled receptor, RXFP4. Although the complete physiological ...
- Leader Peptide-Directed Processing of Labyrinthopeptin A2 Precursor Peptide by the Modifying Enzyme LabKC
[作者:Muller, WM; Ensle, P; Krawczyk, B; Sussmuth, RD,期刊:Biochemistry, 页码:8362-8373 , 文章类型: Article,,卷期:2011年50-39]
- Lantibiotics are peptide antibiotics, realizing their unique secondary structure by posttranslational modifications, the most important one being the formation of the characteristic amino acid lanthionine. Like other rib...
- Structural and Biochemical Characterization of Zhul Aromatase/Cyclase from the R1128 Polyketide Pathway
[作者:Ames, BD; Lee, MY; Moody, C; Zhang, WJ; Tang, Y; Tsai, SC,期刊:Biochemistry, 页码:8392-8406 , 文章类型: Article,,卷期:2011年50-39]
- Aromatic polyketides comprise an important class of natural products that possess a wide range of biological activities. The cyclization of the polyketide chain is a critical control point in the biosynthesis of aromatic...
- Investigating the Molecular Determinants for Substrate Channeling in BphI-BphJ, an Aldolase-Dehydrogenase Complex from the Polychlorinated Biphenyls Degradation Pathway
[作者:Carere, J; Baker, P; Seah, SYK,期刊:Biochemistry, 页码:8407-8416 , 文章类型: Article,,卷期:2011年50-39]
- BphI-BphJ, an aldolase-dehydrogenase complex from the polychlorinated biphenyls (PCBs) degradation pathway, cleaves 4-hydroxy-2-oxoacids to pyruvate and an aldehyde. The enzyme complex was shown to exhibit substrate chan...
- Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor
[作者:Petrenko, N; Khafizov, K; Tvrdonova, V; Skorinkin, A; Giniatullin, R,期刊:Biochemistry, 页码:8427-8436 , 文章类型: Article,,卷期:2011年50-39]
- ATP-activated P2X3 receptors expressed in nociceptive sensory neurons play an important role in pain signaling. Basic properties of this receptor subtype, including very strong desensitization, depend on the rate of diss...
- Reversible Heme-Dependent Regulation of Human Cystathionine beta-Synthase by a Flavoprotein Oxidoreductase
[作者:Kabil, O; Weeks, CL; Carballal, S; Gherasim, C; Alvarez, B; Spiro, TG; Banerjee, R,期刊:Biochemistry, 页码:8261-8263 , 文章类型: Article,,卷期:2011年50-39]
- Human CBS is a PLP-dependent enzyme that clears homocysteine, gates the flow of sulfur into glutathione, and contributes to the biogenesis of H(2)S. The presence of a heme cofactor in CBS is enigmatic, and its conversion...
- The Original Michaelis Constant: Translation of the 1913 Michaelis-Menten Paper
[作者:Johnson, KA; Goody, RS,期刊:Biochemistry, 页码:8264-8269 , 文章类型: Article,,卷期:2011年50-39]
- Nearly 100 years ago Michaelis and Menten published their now classic paper [Michaelis, L., and Menten, M. L. (1913) Die Kinetik der Invertinwirkung. Biochem. Z. 49, 333-369] in which they showed that the rate of an enzy...
- Investigating Deinococcus radiodurans RecA Protein Filament Formation on Double-Stranded DNA by a Real-Time Single-Molecule Approach
[作者:Hsu, HF; Ngo, KV; Chitteni-Pattu, S; Cox, MM; Li, HW,期刊:Biochemistry, 页码:8270-8280 , 文章类型: Article,,卷期:2011年50-39]
- With the aid of an efficient, precise, and almost error-free DNA repair system, Deinococcus radiodurans can survive hundreds of double strand breaks inflicted by high doses of irradiation or desiccation. RecA of D. radio...
- Fibrillation of the Major Curli Subunit CsgA under a Wide Range of Conditions Implies a Robust Design of Aggregation
[作者:Dueholm, MS; Nielsen, SB; Hein, KL; Nissen, P; Chapman, M; Christiansen, G; Nielsen, PH; Otzen, DE,期刊:Biochemistry, 页码:8281-8290 , 文章类型: Article,,卷期:2011年50-39]
- The amyloid fold is usually considered a result of protein misfolding. However, a number of studies have recently shown that the amyloid structure is also used in nature for functional purposes. CsgA is the major subunit...
- Trolox, a Water-Soluble Analogue of alpha-Tocopherol, Photoprotects the Surface-Exposed Regions of the Photosystem II Reaction Center in Vitro. Is This Physiologically Relevant?
[作者:Arellano, JB; Li, H; Gonzalez-Perez, S; Gutierrez, J; Melo, TB; Vacha, F; Naqvi, KR,期刊:Biochemistry, 页码:8291-8301 , 文章类型: Article,,卷期:2011年50-39]
- Can Trolox, a water-soluble analogue of alpha-tocopherol and a scavenger of singlet oxygen ((1)O(2)), provide photoprotection, under high irradiance, to the isolated photosystem II (PSII) reaction center (RC)? To answer ...
- Role of a Mutated Residue at the Entrance of the Substrate Access Channel in Cytochrome P450 Engineered for Vitamin D(3) Hydroxylation Activity
[作者:Fukunishi, H; Yagi, H; Kamijo, K; Shimada, J,期刊:Biochemistry, 页码:8302-8310 , 文章类型: Article,,卷期:2011年50-39]
- The cytochrome P450 enzyme engineered for enhancement of vitamin D(3) (VD(3)) hydroxylation activity, Vdh-K1, includes four mutations (T70R, V156L, E216M, and E384R) compared to the wild-type enzyme. Plausible roles for ...
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