- Nanodiscs versus Macrodiscs for NMR of Membrane Proteins
[作者：Park, SH; Berkamp, S; Cook, GA; Chan, MK; Viadiu, H; Opella, SJ,期刊：Biochemistry, 页码：8983-8985 , 文章类型： Article，,卷期：2011年50-42]
- It is challenging to find membrane mimics that stabilize the native structures, dynamics, and functions of membrane proteins. In a recent advance, nanodiscs have been shown to provide a bilayer environment compatible wit...
- In Vitro Phosphinate Methylation by PhpK from Kitasatospora phosalacinea
[作者：Werner, WJ; Allen, KD; Hu, KF; Helms, GL; Chen, BS; Wang, SC,期刊：Biochemistry, 页码：8986-8988 , 文章类型： Article，,卷期：2011年50-42]
- Radical S-adenosyl-L-methionine, cobalamin-dependent methyltransferases have been proposed. to catalyze the methylations of unreactive carbon or phosphorus atoms in antibiotic biosynthetic pathways. To date, none of thes...
- Ultrafast Fluorescence Decay Profiles Reveal Differential Unstacking of 2-Aminopurine from Neighboring Bases in Single-Stranded DNA-Binding Protein Subsites
[作者：Nguyen, HN; Zhao, L; Gray, CW; Gray, DM; Xia, TB,期刊：Biochemistry, 页码：8989-9001 , 文章类型： Article，,卷期：2011年50-42]
- Gene 5 protein (g5p) is a dimeric single-stranded DNA-binding protein encoded by Ff strains of Escherichia cob bacteriophages. The 2-fold rotationally symmetric binding sites of a g5p dimer each bind to four nucleotides,...
- Altering Residues N125 and D149 Impacts Sugar Effector Binding and Allosteric Parameters in Escherichia coli Lactose Repressor
[作者：Xu, J; Liu, S; Chen, MZ; Ma, JP; Matthews, KS,期刊：Biochemistry, 页码：9002-9013 , 文章类型： Article，,卷期：2011年50-42]
- Lactose repressor protein (Lacl), a negative transcriptional regulator in Escherichia coil, relies on an allosteric conformational change for its function. The Lad effector isopropyl-beta,D-thiogalactoside (IPTG) promote...
- Dissociation between the Processivity and Total Activity of gamma-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations
[作者：Quintero-Monzon, O; Martin, MM; Fernandez, MA; Cappello, CA; Krzysiak, AJ; Osenkowski, P; Wolfe, MS,期刊：Biochemistry, 页码：9023-9035 , 文章类型： Article，,卷期：2011年50-42]
- The amyloid beta-peptide (A beta), strongly implicated in the pathogenesis of Alzheimer's disease (AD), is produced from the amyloid beta-protein precursor (APP) through consecutive proteolysis by beta- and gamma-secreta...
- Spectroscopic Characterization of the Metal-Binding Sites in the Periplasmic Metal-Sensor Domain of CnrX from Cupriavidus metallidurans CH34
[作者：Trepreau, J; de Rosny, E; Duboc, C; Sarret, G; Petit-Hartlein, I; Maillard, AP; Imberty, A; Proux, O; Coves, J,期刊：Biochemistry, 页码：9036-9045 , 文章类型： Article，,卷期：2011年50-42]
- CnrX, the dimeric metal sensor of the three-protein transmembrane signal transduction complex CnrYXH of Cupriavidus metallidurans CH34, contains one metal-binding site per monomer. Both Ni and Co elicit a biological resp...
- Substitution of the Human alpha C Region with the Analogous Chicken Domain Generates a Fibrinogen with Severely Impaired Lateral Aggregation: Fibrin Monomers Assemble into Protofibrils but Protofibrils Do Not Assemble into Fibers
[作者：Ping, LF; Huang, LH; Cardinali, B; Profumo, A; Gorkun, OV; Lord, ST,期刊：Biochemistry, 页码：9066-9075 , 文章类型： Article，,卷期：2011年50-42]
- Fibrin polymerization occurs in two steps: the assembly of fibrin monomers into protofibrils and the lateral aggregation of protofibrils into fibers. Here we describe a novel fibrinogen that apparently impairs only later...
- Independent Interactions of Ubiquitin-Binding Domains in a Ubiquitin-Mediated Ternary Complex
[作者：Garner, TP; Strachan, J; Shedden, EC; Long, JE; Cavey, JR; Shaw, B; Layfield, R; Searle, MS,期刊：Biochemistry, 页码：9076-9087 , 文章类型： Article，,卷期：2011年50-42]
- Ubiquitin (Ub) modifications are transduced by receptor proteins that use Ub-binding domains (UBDs) to recognize distinct interaction faces on the Ub surface. We report the nuclear magnetic resonance (NMR) solution struc...
- Thermodynamics of Nucleic Acid "Shape Readout" by an Aminosugar
[作者：Xi, HJ; Davis, E; Ranjan, N; Xue, L; Hyde-Volpe, D; Arya, DP,期刊：Biochemistry, 页码：9088-9113 , 文章类型： Article，,卷期：2011年50-42]
- Recognition of nucleic acids is important for our understanding of nucleic acid structure as well as for our understanding of nucleic acid protein interactions. In addition to the direct readout mechanisms of nucleic aci...
- Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase
[作者：Xia, SL; Wang, MN; Blaha, G; Konigsberg, WH; Wang, JM,期刊：Biochemistry, 页码：9114-9124 , 文章类型： Article，,卷期：2011年50-42]
- We have captured a preinsertion ternary complex of RB69 DNA polymerase (RB69pol) containing the 3' hydroxyl group at the terminus of an extendable primer (ptO3') and a nonhydrolyzable 2'-deoxyuridine 5'-alpha,beta-substi...
- Structural and Kinetic Studies on Metallo-beta-lactamase IMP-1
[作者：Griffin, DH; Richmond, TK; Sanchez, C; Moller, AJ; Breece, RM; Tierney, DL; Bennett, B; Crowder, MW,期刊：Biochemistry, 页码：9125-9134 , 文章类型： Article，,卷期：2011年50-42]
- In an effort to probe for metal binding to metallo-beta-lactamase (m beta L) IMP-1, the enzyme was overexpressed, purified, and characterized. The resulting enzyme was shown to bind 2 equiv of Zn(II), exhibit significant...
- Characterization of Sulfolipids of Mycobacterium tuberculosis H37Rv by Multiple-Stage Linear Ion-Trap High-Resolution Mass Spectrometry with Electrospray Ionization Reveals That the Family of Sulfolipid II Predominates
[作者：Rhoades, ER; Streeter, C; Turk, J; Hsu, FF,期刊：Biochemistry, 页码：9135-9147 , 文章类型： Article，,卷期：2011年50-42]
- Mycobacterium tuberculosis, the causative agent of tuberculosis, is unique among bacterial pathogens in that it contains a wide array of complex lipids and lipoglycans on its cell wall. Among them, the sulfated glycolipi...
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