- The Enzyme Function Initiative
[作者:Gerlt, JA; Allen, KN; Almo, SC; Armstrong, RN; Babbitt, PC; Cronan, JE; Dunaway-Mariano, D; Imker, HJ; Jacobson, MP; Minor, W; Poulter, CD; Raushel, FM; Sali, A; Shoichet, BK; Sweedler, JV,期刊:Biochemistry, 页码:9950-9962 , 文章类型: Article,,卷期:2011年50-46]
- The Enzyme Function Initiative (EFI) was recently established to address the challenge of assigning reliable functions to enzymes discovered in bacterial genome projects; in this Current Topic, we review the structure an...
- Post-Translational Modifications and Lipid Binding Profile of Insect Cell-Expressed Full-Length Mammalian Synaptotagmin 1
[作者:Vrljic, M; Strop, P; Hill, RC; Hansen, KC; Chu, S; Brunger, AT,期刊:Biochemistry, 页码:9998-10012 , 文章类型: Article,,卷期:2011年50-46]
- Synaptotagmin 1 (Syt1) is a Ca(2+) sensor for SNARE-mediated, Ca(2+)-triggered synaptic vesicle fusion in neurons. It is composed of luminal, transmembrane, linker, and two Ca(2+)-binding (C2) domains. Here we describe e...
- Allosteric Activation of Cytochrome P450 3A4 by alpha-Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis
[作者:Woods, CM; Fernandez, C; Kunze, KL; Atkins, WM,期刊:Biochemistry, 页码:10041-10051 , 文章类型: Article,,卷期:2011年50-46]
- Cytochrome P450 3A4 (CYP3A4) is the dominant xenobiotic metabolizing CYP. Despite great interest in CYP enzymology, two in vitro aspects of CYP3A4 catalysis are still not well understood, namely, sequential metabolism an...
- Increasing Stability and Toxicity of Pseudomonas Exotoxin by Attaching an Antiproteasic Peptide
[作者:Mere, J; Chopard, C; Bonhoure, A; Morlon-Guyot, J; Beaumelle, B,期刊:Biochemistry, 页码:10052-10060 , 文章类型: Article,,卷期:2011年50-46]
- Trypsin-like activities are present within the endocytic pathway and allow cells to inactivate a fraction of incoming toxins, such as Pseudomonas exotoxin (PE), that require endocytic uptake before reaching the cytosol t...
- Substrate Specificity of Low-Molecular Mass Bacterial DD-Peptidases
[作者:Nemmara, VV; Dzhekieva, L; Sarkar, KS; Adediran, SA; Duez, C; Nicholas, RA; Prattt, RF,期刊:Biochemistry, 页码:10091-10101 , 文章类型: Article,,卷期:2011年50-46]
- The bacterial DD-peptidases or penicillin-binding proteins (PBPs) catalyze the formation and regulation of cross-links in peptidoglycan biosynthesis. They are classified into two groups, the high-molecular mass (HMM) and...
- Characterization of Purified New Delhi Metallo-beta-lactamase-1
[作者:Thomas, PW; Zheng, M; Wu, SS; Guo, H; Liu, DL; Xu, DG; Fast, W,期刊:Biochemistry, 页码:10102-10113 , 文章类型: Article,,卷期:2011年50-46]
- New Delhi metallo-beta-lactmase-1 (NDM-1) has recently emerged as a global threat because of its ability to confer resistance to almost all clinically used beta-lactam antibiotics, its presence within an easily transmiss...
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