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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Dissecting the Structure, Thermodynamic Stability, and Aggregation Properties of the A25T Transthyretin (A25T-TTR) Variant Involved in Leptomeningeal Amyloidosis: Identifying Protein Partners That Co-Aggregate during A25T-TTR Fibrillogenesis in Cerebrospinal Fluid [作者：Azevedo, EPC; Pereira, HM; Garratt, RC; Kelly, JW; Foguel, D; Palhano, FL,期刊：Biochemistry, 页码：11070-11083 , 文章类型： Article，,卷期：2011年50-51] Deposition of amorphous aggregates and fibrils of transthyretin (TTR) in leptomeninges and subarachnoid vessels is a characteristic of leptomeningeal amyloidosis (LA), a currently untreatable cerebral angiopathy. Herein,... Nondegradative Ubiquitination of Apoptosis Inducing Factor (AIF) by X-Linked Inhibitor of Apoptosis at a Residue Critical for AIF-Mediated Chromatin Degradation [作者：Lewis, EM; Wilkinson, AS; Davis, NY; Horita, DA; Wilkinson, JC,期刊：Biochemistry, 页码：11084-11096 , 文章类型： Article，,卷期：2011年50-51] Apoptosis inducing factor (AIF) is a mediator of caspase-independent cell death that is also necessary for mitochondrial energy production. How these seemingly opposite cellular functions of AIF are controlled is poorly ... Using Infrared Spectroscopy of Cyanylated Cysteine To Map the Membrane Binding Structure and Orientation of the Hybrid Antimicrobial Peptide CM15 [作者：Alfieri, KN; Vienneau, AR; Londergan, CH,期刊：Biochemistry, 页码：11097-11108 , 文章类型： Article，,卷期：2011年50-51] The synthetic antimicrobial peptide CM15, a hybrid of N-terminal sequences from cecropin and melittin peptides, has been shown to be extremely potent. Its mechanism of action has been thought to involve pore formation ba... Protonation States of Important Acidic Residues in the Central Ca(2+) Ion Binding Sites of the Ca(2+)-ATPase: A Molecular Modeling Study [作者：Musgaard, M; Thogersen, L; Schiott, B,期刊：Biochemistry, 页码：11109-11120 , 文章类型： Article，,卷期：2011年50-51] The P-type ATPases are responsible for the transport of cations across cell membranes. The sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) transports two Ca(2+) ions from the cytoplasm to the lumen of the sarco(endo)p... Structure and Dynamics of Mycobacterium tuberculosis Truncated Hemoglobin N: Insights from NMR Spectroscopy and Molecular Dynamics Simulations [作者：Savard, PY; Daigle, R; Morin, S; Sebilo, A; Meindre, F; Lague, P; Guertin, M; Gagne, SM,期刊：Biochemistry, 页码：11121-11130 , 文章类型： Article，,卷期：2011年50-51] The potent nitric oxide dioxygenase (NOD) activity (trHbN-Fe(2+)-O(2) + (center dot)NO -> trHbN-Fe(3+)-OH(2) + NO(3)(-)) of Mycobacterium tuberculosis truncated hemoglobin N (trHbN) protects aerobic respiration from inhi... Tryptophan 697 Modulates Hydride and Interflavin Electron Transfer in Human Methionine Synthase Reductase [作者：Meints, CE; Gustafsson, FS; Scrutton, NS; Woltherst, KR,期刊：Biochemistry, 页码：11131-11142 , 文章类型： Article，,卷期：2011年50-51] Human methionine synthase reductase (MSR), a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase (MS) activity. MSR catalyzes the oxidation of NADPH and shutt... Phosphatidylinositol 3,4,5-Trisphosphate Activity Probes for the Labeling and Proteomic Characterization of Protein Binding Partners [作者：Rowland, MM; Bostic, HE; Gong, DH; Speers, AE; Lucas, N; Cho, WH; Cravatt, BF; Best, MD,期刊：Biochemistry, 页码：11143-11161 , 文章类型： Article，,卷期：2011年50-51] Phosphatidylinositol polyphosphate lipids, such as phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P(3)], regulate critical biological processes, many of which are aberrant in disease. These lipids often act as site-s... On the Collective Nature of Phytochrome Photoactivation [作者：Song, C; Psakis, G; Lang, C; Mailliet, J; Zaanen, J; Gartner, W; Hughes, J; Matysik, J,期刊：Biochemistry, 页码：10987-10989 , 文章类型： Article，,卷期：2011年50-51] The red/far-red-sensing biological photoreceptor phytochrome is a paradigmatic two-state signaling system. The two thermally stable states are interconverted via a photoreaction of the covalently bound tetrapyrrole chrom... Dimerization-Induced Folding of MST1 SARAH and the Influence of the Intrinsically Unstructured Inhibitory Domain: Low Thermodynamic Stability of Monomer [作者：Aruxandei, DC; Makbul, C; Koturenkiene, A; Ludemann, MB; Herrmann, C,期刊：Biochemistry, 页码：10990-11000 , 文章类型： Article，,卷期：2011年50-51] The serine/threonine mammalian sterile 20-like kinase (MST1) is involved in promotion of caspase-dependent and independent apoptosis. Phosphorylation and oligomerization are required for its activation. The oligomerizati... The Structure, Dynamics, and Binding of the LA45 Module Pair of the Low-Density Lipoprotein Receptor Suggest an Important Role for LA4 in Ligand Release [作者：Guttman, M; Komives, EA,期刊：Biochemistry, 页码：11001-11008 , 文章类型： Article，,卷期：2011年50-51] The low-density lipoprotein receptor (LDLR), the primary receptor for cholesterol uptake, binds ligands through its seven LDL-A modules (LAs). We present nuclear magnetic resonance (NMR) and ligand binding measurements o... Sugar Recognition by CscB and LacY [作者：Sugihara, J; Smirnova, I; Kasho, V; Kaback, HR,期刊：Biochemistry, 页码：11009-11014 , 文章类型： Article，,卷期：2011年50-51] The sucrose permease (CscB) and lactose permease (LacY) of Escherichia colt belong to the oligosaccharide/H(+) symporter subfamily of the major facilitator superfamily, and both catalyze sugar/H(+) symport across the cyt... Lipid-Mediated Unfolding of 3 beta-Hydroxysteroid Dehydrogenase 2 Is Essential for Steroidogenic Activity [作者：Rajapaksha, M; Thomas, JL; Streeter, M; Prasad, M; Whittal, RM; Bell, JD; Bose, HS,期刊：Biochemistry, 页码：11015-11024 , 文章类型： Article，,卷期：2011年50-51] For inner mitochondrial membrane (IMM) proteins that do not undergo N-terminal cleavage, the activity may occur in the absence of a receptor present in the mitochondrial membrane. One such protein is human 3 beta-hydroxy... Ligand-Specific Structural Changes in the Vitamin D Receptor in Solution [作者：Singarapu, KK; Zhu, JG; Tonelli, M; Rao, HY; Assadi-Porter, FM; Westler, WM; DeLuca, HF; Markley, JL,期刊：Biochemistry, 页码：11025-11033 , 文章类型： Article，,卷期：2011年50-51] Vitamin D receptor (VDR) is a member of the nuclear hormone receptor superfamily. When bound to a variety of vitamin D analogues, VDR manifests a wide diversity of physiological actions. The molecular mechanism by which ... Double Reduction of Plastoquinone to Plastoquinol in Photosystem 1 [作者：McConnell, MD; Cowgill, JB; Baker, PL; Rappaport, F; Redding, KE,期刊：Biochemistry, 页码：11034-11046 , 文章类型： Article，,卷期：2011年50-51] In Photosystem 1 (PS1), phylloquinone (PhQ) acts as a secondary electron acceptor from chlorophyll ec(3) and also as an electron donor to the iron-sulfur cluster F(x). PSI possesses two virtually equivalent branches of e... Ribose 5-Phosphate Glycation Reduces Cytochrome c Respiratory Activity and Membrane Affinity [作者：Hildick-Smith, GJ; Downey, MC; Gretebeck, LM; Gersten, RA; Sandwick, RK,期刊：Biochemistry, 页码：11047-11057 , 文章类型： Article，,卷期：2011年50-51] Spontaneous glycation of bovine heart cytochrome c (cyt c) by the sugar ribose 5-phosphate (RSP) weakens the ability of the heme protein to transfer electrons in the respiratory pathway and to bind to membranes. Trypsin ... Analysis of Substrate Access to Active Sites in Bacterial Multicomponent Monooxygenase Hydroxylases: X-ray Crystal Structure of Xenon-Pressurized Phenol Hydroxylase from Pseudomonas sp OX1 [作者：McCormick, MS; Lippard, SJ,期刊：Biochemistry, 页码：11058-11069 , 文章类型： Article，,卷期：2011年50-51] In all structurally characterized bacterial multicomponent monooxygenase (BMM) hydroxylase proteins, a series of hydrophobic cavities in the alpha-subunit trace a conserved path from the protein exterior to the carboxyla...