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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   The Need to Redefine Antimicrobial Drug Discovery [作者：Mylonakis, E,期刊：Current Pharmaceutical Design, 页码：1223-1224 , 文章类型： Editorial Material，,卷期：2011年17-13] Caenorhabditis elegans-based Model Systems for Antifungal Drug Discovery [作者：Anastassopoulou, CG; Fuchs, BB; Mylonakis, E,期刊：Current Pharmaceutical Design, 页码：1225-1233 , 文章类型： Review，,卷期：2011年17-13] The substantial morbidity and mortality associated with invasive fungal infections constitute undisputed tokens of their severity. The continued expansion of susceptible population groups (such as immunocompromised indiv... Application of Cell-free Hemolymph of Horseshoe Crab in Antimicrobial Drug Screening [作者：Du, RJ; Ho, B; Ding, JL,期刊：Current Pharmaceutical Design, 页码：1234-1239 , 文章类型： Review，,卷期：2011年17-13] Horseshoe crabs are an ancient invertebrate which possesses powerful innate immune defense against microbes. The simplicity, specificity and rapidity of its antimicrobial response have accorded the horseshoe crab as an e... ANTI-infective Therapeutics from the Lepidopteran Model Host Galleria mellonella [作者：Vilcinskas, A,期刊：Current Pharmaceutical Design, 页码：1240-1245 , 文章类型： Review，,卷期：2011年17-13] The larvae of the greater wax moth Galleria mellonella prosper in use both as surrogate alternative model hosts for human pathogens and as a whole-animal-high-throughput-system for in vivo testing of antibiotics or mutan... Drosophila melanogaster As a Model Host for the Study of Microbial Pathogenicity And the Discovery of Novel Antimicrobial Compounds [作者：Chamilos, G; Samonis, G; Kontoyiannis, DP,期刊：Current Pharmaceutical Design, 页码：1246-1253 , 文章类型： Review，,卷期：2011年17-13] The past few decades have seen alarming rates of antimicrobial drug resistance. This trend paralleled a lack of conventional methods of discovery of antibiotics with novel mechanisms of action. Although use of mammalian ... Host Stress and Virulence Expression in Intestinal Pathogens: Development of Therapeutic Strategies Using Mice and C. elegans [作者：Zaborina, O; Zaborin, A; Romanowski, K; Babrowski, T; Alverdy, J,期刊：Current Pharmaceutical Design, 页码：1254-1260 , 文章类型： Review，,卷期：2011年17-13] The intestinal tract of a host exposed to extreme physiologic stress and modern medical intervention represents a relatively unexplored yet important area of infection research, given the frequency with which this site b... Humanized SCID Mice Models of SLE [作者：Kerekov, N; Mihaylova, N; Prechl, J; Tchorbanov, A,期刊：Current Pharmaceutical Design, 页码：1261-1266 , 文章类型： Review，,卷期：2011年17-13] The pathological DNA-specific B cells in Systemic lupus erythematosus are a logical target for a selected therapeutic intervention. It has been recently shown that complement receptor type 1 on human B and T-lymphocytes ... Natural Resins and Bioactive Natural Products thereof as Potential Anitimicrobial Agents [作者：Termentzi, A; Fokialakis, N; Skaltsounis, AL,期刊：Current Pharmaceutical Design, 页码：1267-1290 , 文章类型： Review，,卷期：2011年17-13] Natural products and their derivatives have historically been invaluable as a source of therapeutic agents and have contributed to the discovery of antimicrobial agents. However, today with the development of drug-resist... Microbial Efflux Pump Inhibition: Tactics and Strategies [作者：Tegos, GP; Haynes, M; Strouse, J; Khan, MMT; Bologa, CG; Oprea, TI; Sklar, LA,期刊：Current Pharmaceutical Design, 页码：1291-1302 , 文章类型： Review，,卷期：2011年17-13] Traditional antimicrobials are increasingly suffering from the emergence of multidrug resistance among pathogenic microorganisms. To overcome these deficiencies, a range of novel approaches to control microbial infection... Drug Discovery of Antimicrobial Photosensitizers Using Animal Models [作者：Sharma, SK; Dai, TH; Kharkwal, GB; Huang, YY; Huang, LY; De Arce, VJB; Tegos, GP; Hamblin, MR,期刊：Current Pharmaceutical Design, 页码：1303-1319 , 文章类型： Review，,卷期：2011年17-13] Antimicrobial photodynamic therapy (aPDT) is an emerging alternative to antibiotics motivated by growing problems with multi-drug resistant pathogens. aPDT uses non-toxic dyes or photosensitizers (PS) in combination with...