- Vibrio vulnificus rpoS Expression Is Repressed by Direct Binding of cAMP-cAMP Receptor Protein Complex to Its Two Promoter Regions
[作者:Lee, HJ; Park, SJ; Choi, SH; Lee, KH,期刊:Journal of Biological Chemistry, 页码:30438-30450 , 文章类型: Article,,卷期:2008年283-45]
- Vibrio vulnificus, a septicemia-causing pathogenic bacterium, acquires resistance against various stresses and expresses virulence factors via an rpoS gene product. In this study, we investigated the transcriptional char...
- Complement Factor H Binds to Denatured Rather than to Native Pentameric C-reactive Protein
[作者:Hakobyan, S; Harris, CL; van den Berg, CW; Fernandez-Alonso, MC; de Jorge, EG; de Cordoba, SR; Rivas, G; Mangione, P; Pepys, MB; Morgan, BP,期刊:Journal of Biological Chemistry, 页码:30451-30460 , 文章类型: Article,,卷期:2008年283-45]
- Binding of the complement regulatory protein, factor H, to C-reactive protein has been reported and implicated as the biological basis for association of the H402 polymorphic variant of factor H with macular degeneration...
- UCP2 Modulates Cell Proliferation through the MAPK/ERK Pathway during Erythropoiesis and Has No Effect on Heme Biosynthesis
[作者:Elorza, A; Hyde, B; Mikkola, HK; Collins, S; Shirihai, OS,期刊:Journal of Biological Chemistry, 页码:30461-30470 , 文章类型: Article,,卷期:2008年283-45]
- UCP2, an inner membrane mitochondrial protein, has been implicated in bioenergetics and reactive oxygen species (ROS) modulation. High levels of UCP2 mRNA were recently found in erythroid cells where UCP2 is hypothesized...
- The Human Cathelicidin LL-37 Modulates the Activities of the P2X(7) Receptor in a Structure-dependent Manner
[作者:Tomasinsig, L; Pizzirani, C; Skerlavaj, B; Pellegatti, P; Gulinelli, S; Tossi, A; Di Virgilio, F; Zanetti, M,期刊:Journal of Biological Chemistry, 页码:30471-30481 , 文章类型: Article,,卷期:2008年283-45]
- Extracellular ATP, released at sites of inflammation or tissue damage, activates the P2X(7) receptor, which in turn triggers a range of responses also including cell proliferation. In this study the ability of the human ...
- Dissociation of Activated Protein C Functions by Elimination of Protein S Cofactor Enhancement
[作者:Harmon, S; Preston, RJS; Ainle, FN; Johnson, JA; Cunningham, MS; Smith, OP; White, B; O'Donnell, JS,期刊:Journal of Biological Chemistry, 页码:30531-30539 , 文章类型: Article,,卷期:2008年283-45]
- Activated protein C (APC) plays a critical anticoagulant role in vivo by inactivating procoagulant factor Va and factor VIIIa and thus down-regulating thrombin generation. In addition, APC bound to the endothelial cell p...
- Paradoxical Effect of Mitochondrial Respiratory Chain Impairment on Insulin Signaling and Glucose Transport in Adipose Cells
[作者:Shi, XR; Burkart, A; Nicoloro, SM; Czech, MP; Straubhaar, J; Corvera, S,期刊:Journal of Biological Chemistry, 页码:30658-30667 , 文章类型: Article,,卷期:2008年283-45]
- Adipocyte function is crucial for the control of whole body energy homeostasis. Pathway analysis of differentiating 3T3-L1 adipocytes reveals that major metabolic pathways induced during differentiation involve mitochond...
- Homomeric and Heteromeric Assembly of KCNQ (Kv7) K+ Channels Assayed by Total Internal Reflection Fluorescence/Fluorescence Resonance Energy Transfer and Patch Clamp Analysis
[作者:Bal, M; Zhang, J; Zaika, O; Hernandez, CC; Shapiro, MS,期刊:Journal of Biological Chemistry, 页码:30668-30676 , 文章类型: Article,,卷期:2008年283-45]
- M-type K+ channels, consisting of KCNQ1-5 (Kv7.1-7.5) subunits, form a variety of homomeric and heteromeric channels. Whereas all the subunits can assemble into homomeric channels, the ability of the subunits to assemble...
- Syntaxin 6, a Regulator of the Protein Trafficking Machinery and a Target of the p53 Family, Is Required for Cell Adhesion and Survival
[作者:Zhang, YH; Shu, LM; Chen, XB,期刊:Journal of Biological Chemistry, 页码:30689-30698 , 文章类型: Article,,卷期:2008年283-45]
- The p53 family consists of p53, p63, and p73. It has been well characterized that all of the p53 family proteins are transcription factors and capable of regulating cell cycle and apoptosis. To determine whether the p53 ...
- Protection of Cardiomyocytes from Ischemic/Hypoxic Cell Death via Drbp1 and pMe(2)GlyDH in Cardio-specific ARC Transgenic Mice
[作者:Pyo, JO; Nah, J; Kim, HJ; Chang, JW; Song, YW; Yang, DK; Jo, DG; Kim, HR; Chae, HJ; Chae, SW; Hwang, SY; Kim, SJ; Kim, HJ; Cho, C; Oh, CG; Park, WJ; Jung, YK,期刊:Journal of Biological Chemistry, 页码:30707-30714 , 文章类型: Article,,卷期:2008年283-45]
- The ischemic death of cardiomyocytes is associated in heart disease and heart failure. However, the molecular mechanism underlying ischemic cell death is not well defined. To examine the function of apoptosis repressor w...
- Impaired Regulation of Brain Mitochondria by Extramitochondrial Ca2+ in Transgenic Huntington Disease Rats
[作者:Gellerich, FN; Gizatullina, Z; Nguyen, HP; Trumbeckaite, S; Vielhaber, S; Seppet, E; Zierz, S; Landwehrmeyer, B; Riess, O; von Horsten, S; Striggow, F,期刊:Journal of Biological Chemistry, 页码:30715-30724 , 文章类型: Article,,卷期:2008年283-45]
- Huntington disease ( HD) is characterized by polyglutamine expansions of huntingtin (htt), but the underlying pathomechanisms have remained unclear. We studied brain mitochondria of transgenic HD rats with 51 glutamine r...
- Fbxw7 Acts as an E3 Ubiquitin Ligase That Targets c-Myb for Nemo-like Kinase (NLK)-induced Degradation
[作者:Kanei-Ishii, C; Nomura, T; Takagi, T; Watanabe, N; Nakayama, KI; Ishii, S,期刊:Journal of Biological Chemistry, 页码:30540-30548 , 文章类型: Article,,卷期:2008年283-45]
- The c-myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via a pathway involving TAK1 (transforming growth factor-beta-activated kinase 1), HIPK2 (homeodomain-interacting protein kinase 2), and...
- Characterization of Truncated Forms of Abnormal Prion Protein in Creutzfeldt-Jakob Disease
[作者:Notari, S; Strammiello, R; Capellari, S; Giese, A; Cescatti, M; Grassi, J; Ghetti, B; Langeveld, JPM; Zou, WQ; Gambetti, P; Kretzschmar, HA; Parchi, P,期刊:Journal of Biological Chemistry, 页码:30557-30565 , 文章类型: Article,,卷期:2008年283-45]
- In prion disease, the abnormal conformer of the cellular prion protein, PrPSc, deposits in fibrillar protein aggregates in brain and other organs. Limited exposure of PrPSc to proteolytic digestion in vitro generates a c...
- Glycogen Synthase Kinase 3 beta Is a Novel Regulator of High Glucose- and High Insulin-induced Extracellular Matrix Protein Synthesis in Renal Proximal Tubular Epithelial Cells
[作者:Mariappan, MM; Shetty, M; Sataranatarajan, K; Choudhury, GG; Kasinath, BS,期刊:Journal of Biological Chemistry, 页码:30566-30575 , 文章类型: Article,,卷期:2008年283-45]
- High glucose (30 mM) and high insulin (1 nM), pathogenic factors of type 2 diabetes, increased mRNA expression and synthesis of laminin beta 1 and fibronectin after 24 h of incubation in kidney proximal tubular epithelia...
- Laminin-332 Is a Substrate for Hepsin, a Protease Associated with Prostate Cancer Progression
[作者:Tripathi, M; Nandana, S; Yamashita, H; Ganesan, R; Kirchhofer, D; Quaranta, V,期刊:Journal of Biological Chemistry, 页码:30576-30584 , 文章类型: Article,,卷期:2008年283-45]
- Hepsin, a cell surface protease, is widely reported to be over-expressed in more than 90% of human prostate tumors. Hepsin expression correlates with tumor progression, making it a significant marker and target for prost...
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