- NEU3 Sialidase Strictly Modulates GM3 Levels in Skeletal Myoblasts C2C12 Thus Favoring Their Differentiation and Protecting Them from Apoptosis
[作者:Anastasia, L; Papini, N; Colazzo, F; Palazzolo, G; Tringali, C; Dileo, L; Piccoli, M; Conforti, E; Sitzia, C; Monti, E; Sampaolesi, M; Tettamanti, G; Venerando, B,期刊:Journal of Biological Chemistry, 页码:36265-36271 , 文章类型: Article,,卷期:2008年283-52]
- Membrane-bound sialidase NEU3, often referred to as the "ganglioside sialidase," has a critical regulatory function on the sialoglycosphingolipid pattern of the cell membrane, with an anti-apoptotic function, especially ...
- PfbA, a Novel Plasmin- and Fibronectin-binding Protein of Streptococcus pneumoniae, Contributes to Fibronectin-dependent Adhesion and Antiphagocytosis
[作者:Yamaguchi, M; Terao, Y; Mori, Y; Hamada, S; Kawabata, S,期刊:Journal of Biological Chemistry, 页码:36272-36279 , 文章类型: Article,,卷期:2008年283-52]
- Streptococcus pneumoniae is a major causative agent of mortality throughout the world. The initial event in invasive pneumococcal disease is the attachment of pneumococci to epithelial cells in the upper respiratory trac...
- Caspase 8 Promotes Peripheral Localization and Activation of Rab5
[作者:Torres, VA; Mielgo, A; Barila, D; Anderson, DH; Stupack, D,期刊:Journal of Biological Chemistry, 页码:36280-36289 , 文章类型: Article,,卷期:2008年283-52]
- Caspase 8 is a cysteine protease that initiates apoptotic signaling via the extrinsic pathway in a manner dependent upon association with early endosomes. Previously, we identified caspase 8 as an effector of migration, ...
- Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase
[作者:Dvir-Ginzberg, M; Gagarina, V; Lee, EJ; Hall, DJ,期刊:Journal of Biological Chemistry, 页码:36300-36310 , 文章类型: Article,,卷期:2008年283-52]
- SirT1 is an NAD-dependent histone deacetylase that regulates gene expression, differentiation, development, and organism life span. Here we investigate the function of SirT1 in human chondrocytes derived from osteoarthri...
- HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase
[作者:Durkin, SS; Guo, X; Fryrear, KA; Mihaylova, VT; Gupta, SK; Belgnaoui, SM; Haoudi, A; Kupfer, GM; Semmes, OJ,期刊:Journal of Biological Chemistry, 页码:36311-36320 , 文章类型: Article,,卷期:2008年283-52]
- Human T-cell leukemia virus type-1 is the causative agent for adult T-cell leukemia. Previous research has established that the viral oncoprotein Tax mediates the transformation process by impairing cell cycle control an...
- Absolute Side-chain Structure at Position 13 Is Required for the Inhibitory Activity of Bromein
[作者:Sawano, Y; Hatano, K; Miyakawa, T; Tanokura, M,期刊:Journal of Biological Chemistry, 页码:36338-36343 , 文章类型: Article,,卷期:2008年283-52]
- Bromelain isoinhibitor (bromein), a cysteine proteinase inhibitor from pineapple stem, has a unique double-chain structure. The bromein precursor protein includes three homologous inhibitor domains, each containing an in...
- Glucose Metabolism Attenuates p53 and Puma-dependent Cell Death upon Growth Factor Deprivation
[作者:Zhao, YX; Coloff, JL; Ferguson, EC; Jacobs, SR; Cui, K; Rathmell, JC,期刊:Journal of Biological Chemistry, 页码:36344-36353 , 文章类型: Article,,卷期:2008年283-52]
- Growth factor stimulation and oncogenic transformation lead to increased glucose metabolism that may provide resistance to cell death. We have previously demonstrated that elevated glucose metabolism characteristic of st...
- Structural and Functional Analysis of a Glycoside Hydrolase Family 97 Enzyme from Bacteroides thetaiotaomicron
[作者:Kitamura, M; Okuyama, M; Tanzawa, F; Mori, H; Kitago, Y; Watanabe, N; Kimura, A; Tanaka, I; Yao, M,期刊:Journal of Biological Chemistry, 页码:36328-36337 , 文章类型: Article,,卷期:2008年283-52]
- SusB, an 84-kDa alpha-glucoside hydrolase involved in the starch utilization system (sus) of Bacteroides thetaiotaomicron, belongs to glycoside hydrolase (GH) family 97. We have determined the enzymatic characteristics a...
- IMP Dehydrogenase Type 1 Associates with Polyribosomes Translating Rhodopsin mRNA
[作者:Mortimer, SE; Xu, D; McGrew, D; Hamaguchi, N; Lim, HC; Bowne, SJ; Daiger, SP; Hedstrom, L,期刊:Journal of Biological Chemistry, 页码:36354-36360 , 文章类型: Article,,卷期:2008年283-52]
- IMP dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis. Here we show that both IMPDH type 1 (IMPDH1) and IMPDH type 2 are associated with polyribosomes, suggesting that these housekeeping...
- DNA Repair and Free Radicals, New Insights into the Mechanism of Spore Photoproduct Lyase Revealed by Single Amino Acid Substitution
[作者:Chandor-Proust, A; Berteau, O; Douki, T; Gasparutto, D; Ollagnier-De-Choudens, S; Fontecave, M; Atta, M,期刊:Journal of Biological Chemistry, 页码:36361-36368 , 文章类型: Article,,卷期:2008年283-52]
- The major DNA photoproduct in UV-irradiated Bacillus subtilis spores is the thymine dimer named spore photoproduct (SP, 5-(alpha-thyminyl)-5,6-dihydrothymine). The SP lesion has been found to be efficiently repaired by S...
- ATP/ADP Binding to a Novel Nucleotide Binding Domain of the Reticulocyte-binding Protein Py235 of Plasmodium yoelii
[作者:Ramalingam, JK; Hunke, C; Gao, XH; Grurber, G; Preiser, PR,期刊:Journal of Biological Chemistry, 页码:36386-36396 , 文章类型: Article,,卷期:2008年283-52]
- The mechanism by which a malaria merozoite recognizes a suitable host cell is mediated by a cascade of receptor-ligand interactions. In addition to the availability of the appropriate receptors, intracellular ATP plays a...
- Diffusion and Directed Movement IN VITRO MOTILE PROPERTIES OF FISSION YEAST KINESIN-14 Pkl1
[作者:Furuta, K; Edamatsu, M; Maeda, Y; Toyoshima, YY,期刊:Journal of Biological Chemistry, 页码:36465-36473 , 文章类型: Article,,卷期:2008年283-52]
- Fission yeast Pkl1 is a kinesin-14A family member that is known to be localized at the cellular spindle and is capable of hydrolyzing ATP. However, its motility has not been detected. Here, we show that Pkl1 is a slow, m...
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