- Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase
[作者:Kranendonk, M; Marohnic, CC; Panda, SP; Duarte, MP; Oliveira, JS; Masters, BSS; Rueff, J,期刊:Archives of Biochemistry and Biophysics , 页码:93-99 , 文章类型: Article,,卷期:2008年475-2]
- Y459H and V492E mutations of cytochrome P450 reductase (CYPOR) cause Antley-Bixler syndrome due to diminished binding of the FAD cofactor. To address whether these mutations impaired the interaction with drug-metabolizin...
- Distinct effects on splicing of two monoclonal antibodies directed against the amino-terminal domain of galectin-3
[作者:Gray, RM; Davis, MJ; Ruby, KM; Voss, PG; Patterson, RJ; Wang, JL,期刊:Archives of Biochemistry and Biophysics , 页码:100-108 , 文章类型: Article,,卷期:2008年475-2]
- Previous experiments had established that galectin-3 (Gal3) is a factor involved in cell-free splicing of pre-mRNA. Addition of monoclonal antibody NCL-GAL3, whose epitope maps to the NH2-terminal 14 amino acids of Gal3,...
- A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS)
[作者:Choi, SE; Lee, YJ; Jang, HJ; Lee, KW; Kim, YS; Jun, HS; Kang, SS; Chun, J; Kang, Y,期刊:Archives of Biochemistry and Biophysics , 页码:109-114 , 文章类型: Article,,卷期:2008年475-2]
- Free fatty acids (FFAs) are believed to be a stimulus to elicit beta cell dysfunction. The present study was undertaken to determine whether endoplasmic reticulum (ER) stress was involved in palmitate-induced inhibition ...
- Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents
[作者:Yang, QL; Li, Y; Dou, DF; Gan, XD; Mohan, S; Groutas, CS; Stevenson, LE; Lai, Z; Alliston, KR; Zhong, JY; Williams, TD; Groutas, WC,期刊:Archives of Biochemistry and Biophysics , 页码:115-120 , 文章类型: Article,,卷期:2008年475-2]
- A new class of carbamylating agents based on the cyclosulfamide scaffold is reported. These compounds were found to be efficient time-dependent inhibitors of human neutrophil elastase (HNE). Exploitation of the three sit...
- Dynamics and cooperativity of Trp-cage folding
[作者:Hu, ZH; Tang, YH; Wang, HF; Zhang, X; Lei, M,期刊:Archives of Biochemistry and Biophysics , 页码:140-147 , 文章类型: Article,,卷期:2008年475-2]
- In this study, multiple independent molecular dynamics (MD) simulations on Trp-cage folding were performed at 300, 325 and 375 K using generalized Born (GB) implicit solvent model. The orientational movement of the side-...
- Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death
[作者:Cheng, Y; Qiu, F; Huang, J; Tashiro, S; Onodera, S; Ikejima, T,期刊:Archives of Biochemistry and Biophysics , 页码:148-155 , 文章类型: Article,,卷期:2008年475-2]
- Calpain, calcium-dependent cysteine protease, is reported here to impose the crucial influence on oridonin-induced L929 cell apoptosis and autophagy. We found that inhibition of calpain increased oridonin-induced Bax act...
- Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose
[作者:Liu, WH; Liu, PQ; Tao, S; Deng, YH; Li, XJ; Lan, T; Zhang, XY; Guo, FF; Huang, WG; Chen, FY; Huang, HQ; Zhou, SF,期刊:Archives of Biochemistry and Biophysics , 页码:128-134 , 文章类型: Article,,卷期:2008年475-2]
- Diabetic nephropathy (DN), one of the most serious microvascular complications of diabetes mellitus, is a major cause of end-stage renal disease. Berberine is one of the main constituents of Coptidis rhizoma and Cortex p...
- Proteasome inhibitors induce apoptosis of prostate cancer cells by inducing nuclear translocation of I kappa B alpha
[作者:Vu, HY; Juvekar, A; Ghosh, C; Ramaswami, S; Le, DH; Vancurova, I,期刊:Archives of Biochemistry and Biophysics , 页码:156-163 , 文章类型: Article,,卷期:2008年475-2]
- Proteasome inhibitors are known to suppress the proteasome-mediated degradation of I kappa B alpha in stimulated cells. This results in the cytoplasmic retention of NF kappa B and its reduced nuclear transcriptional acti...
- Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone
[作者:Hummel, MA; Gannett, PM; Aguilar, J; Tracy, TS,期刊:Archives of Biochemistry and Biophysics , 页码:175-183 , 文章类型: Article,,卷期:2008年475-2]
- CYP2C9 polymorphisms result in reduced enzyme catalytic activity and greater activation by effector molecules as compared to wild-type protein, with the mechanism(s) for these changes in activity not fully elucidated. Th...
|