- Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange
[作者:Munoz-Galvan, S; Tous, C; Blanco, MG; Schwartz, EK; Ehmsen, KT; West, SC; Heyer, WD; Aguilera, A,期刊:Molecular and Cellular Biology, 页码:1592-1603 , 文章类型: Article,,卷期:2012年32-9]
- Most spontaneous DNA double-strand breaks (DSBs) arise during replication and are repaired by homologous recombination (HR) with the sister chromatid. Many proteins participate in HR, but it is often difficult to determi...
- A Balance between Tel1 and Rif2 Activities Regulates Nucleolytic Processing and Elongation at Telomeres
[作者:Martina, M; Clerici, M; Baldo, V; Bonetti, D; Lucchini, G; Longhese, MP,期刊:Molecular and Cellular Biology, 页码:1604-1617 , 文章类型: Article,,卷期:2012年32-9]
- Generation of G-strand overhangs at Saccharomyces cerevisiae yeast telomeres depends primarily on the MRX (Mre11-Rad50-Xrs2) complex, which is also necessary to maintain telomere length by recruiting the Tel1 kinase. MRX...
- Altered Replication in Human Cells Promotes DMPK (CTG)(n)center dot(CAG)(n) Repeat Instability
[作者:Liu, GQ; Chen, XM; Gao, YZ; Lewis, T; Barthelemy, J; Leffak, M,期刊:Molecular and Cellular Biology, 页码:1618-1632 , 文章类型: Article,,卷期:2012年32-9]
- Myotonic dystrophy type 1 (DM1) is associated with expansion of (CTG)(n)center dot(CAG)(n) trinucleotide repeats (TNRs) in the 3' untranslated region (UTR) of the DMPK gene. Replication origins are cis-acting elements th...
- Histone Demethylase KDM5B Collaborates with TFAP2C and Myc To Repress the Cell Cycle Inhibitor p21(cip) (CDKN1A)
[作者:Wong, PP; Miranda, F; Chan, KYV; Berlato, C; Hurst, HC; Scibetta, AG,期刊:Molecular and Cellular Biology, 页码:1633-1644 , 文章类型: Article,,卷期:2012年32-9]
- The TFAP2C transcription factor has been shown to downregulate transcription of the universal cell cycle inhibitor p21(cip) (CDKN1A). In examining the mechanism of TFAP2C-mediated repression, we have identified a ternary...
- Dynamic Changes in Nucleosome Occupancy Are Not Predictive of Gene Expression Dynamics but Are Linked to Transcription and Chromatin Regulators
[作者:Huebert, DJ; Kuan, PF; Keles, S; Gasch, AP,期刊:Molecular and Cellular Biology, 页码:1645-1653 , 文章类型: Article,,卷期:2012年32-9]
- The response to stressful stimuli requires rapid, precise, and dynamic gene expression changes that must be coordinated across the genome. To gain insight into the temporal ordering of genome reorganization, we investiga...
- Biochemical and Phosphoproteomic Analysis of the Helix-Loop-Helix Protein E47
[作者:Teachenor, R; Beck, K; Wright, LYT; Shen, ZX; Briggs, SP; Murre, C,期刊:Molecular and Cellular Biology, 页码:1671-1682 , 文章类型: Article,,卷期:2012年32-9]
- Numerous in vitro as well as genetic studies have demonstrated that the activities of the E2A proteins are regulated at multiple levels, including modulation of DNA binding by the Id proteins, association with the transc...
- Polycomb Repressive Complex 2-Dependent and -Independent Functions of Jarid2 in Transcriptional Regulation in Drosophila
[作者:Herz, HM; Mohan, M; Garrett, AS; Miller, C; Casto, D; Zhang, Y; Seidel, C; Haug, JS; Florens, L; Washburn, MP; Yamaguchi, M; Shiekhattar, R; Shilatifard, A,期刊:Molecular and Cellular Biology, 页码:1683-1693 , 文章类型: Article,,卷期:2012年32-9]
- Jarid2 was recently identified as an important component of the mammalian Polycomb repressive complex 2 (PRC2), where it has a major effect on PRC2 recruitment in mouse embryonic stem cells. Although Jarid2 is conserved ...
- Oxidant-Induced Cell Death and Nrf2-Dependent Antioxidative Response Are Controlled by Fra-1/AP-1
[作者:Vaz, M; Machireddy, N; Irving, A; Potteti, HR; Chevalier, K; Kalvakolanu, D; Reddy, SP,期刊:Molecular and Cellular Biology, 页码:1694-1709 , 文章类型: Article,,卷期:2012年32-9]
- AP-1 (Jun/Fos) transcription factors play key roles in various biological processes, including cell death. Here we report a novel role for Fra-1 in oxidant-induced cell death controlled by modulating antioxidant gene exp...
- Caenorhabditis elegans Dosage Compensation Regulates Histone H4 Chromatin State on X Chromosomes
[作者:Wells, MB; Snyder, MJ; Custer, LM; Csankovszki, G,期刊:Molecular and Cellular Biology, 页码:1710-1719 , 文章类型: Article,,卷期:2012年32-9]
- Dosage compensation equalizes X-linked gene expression between the sexes. This process is achieved in Caenorhabditis elegans by hermaphrodite-specific, dosage compensation complex (DCC)-mediated, 2-fold X chromosome down...
- Transcriptional Activity of Neural Retina Leucine Zipper (Nrl) Is Regulated by c-Jun N-Terminal Kinase and Tip60 during Retina Development
[作者:Kim, JW; Jang, SM; Kim, CH; An, JH; Choi, KH,期刊:Molecular and Cellular Biology, 页码:1720-1732 , 文章类型: Article,,卷期:2012年32-9]
- Neural retina leucine zipper (Nrl), a key basic motif leucine zipper (bZIP) transcription factor, modulates rod photoreceptor differentiation by activating rod-specific target genes. In searching for factors that might c...
- Rab GTPase-Activating Proteins in Autophagy: Regulation of Endocytic and Autophagy Pathways by Direct Binding to Human ATG8 Modifiers
[作者:Popovic, D; Akutsu, M; Novak, I; Harper, JW; Behrends, C; Dikic, I,期刊:Molecular and Cellular Biology, 页码:1733-1744 , 文章类型: Article,,卷期:2012年32-9]
- Autophagy is an evolutionarily conserved degradation pathway characterized by dynamic rearrangement of membranes that sequester cytoplasm, protein aggregates, organelles, and pathogens for delivery to the vacuole and lys...
- Alternative Splicing within the elk-1 5 ' Untranslated Region Serves To Modulate Initiation Events Downstream of the Highly Conserved Upstream Open Reading Frame 2
[作者:Rahim, G; Araud, T; Jaquier-Gubler, P; Curran, J,期刊:Molecular and Cellular Biology, 页码:1745-1756 , 文章类型: Article,,卷期:2012年32-9]
- The 5' untranslated region (UTR) plays a central role in the regulation of mammalian translation initiation. Key components include RNA structure, upstream AUGs (uAUGs), upstream open reading frames (uORFs), and internal...
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