- Haploid Embryonic Stem Cells and the Dominance of Recessive Traits
[作者:Schimenti, J,期刊:Cell Stem Cell, 页码:488-489 , 文章类型: Editorial Material,,卷期:2011年9-6]
- Diploidy, though essential for normal development, is a foil to geneticists. Two recent studies (El ling et al., 2011, this issue of Cell Stem Cell; Leeb and Wutz 2011, Nature), report the isolation of haploid pluripoten...
- Making a Pituitary Gland in a Dish
[作者:Tabar, V,期刊:Cell Stem Cell, 页码:490-491 , 文章类型: Editorial Material,,卷期:2011年9-6]
- The adenohypophysis secretes multiple hormones that control vital physiological functions. A recent article in Nature (Suga et al., 2011) describes a 3D protocol for the derivation of several endocrine pituitary cell typ...
- Epicardial Origin of Cardiac CFU-Fs
[作者:Slukvin, II,期刊:Cell Stem Cell, 页码:492-493 , 文章类型: Editorial Material,,卷期:2011年9-6]
- The epicardium has been recognized as a source of cardiovascular progenitors during embryogenesis and postnatal life. In this issue of Cell Stem Cell, Chong et al. (2011) identify cardiac CFU-Fs as cardiac-resident cells...
- Stem Cell Maintenance of the Mammary Gland: It Takes Two
[作者:Keller, PJ; Arendt, LM; Kuperwasser, C,期刊:Cell Stem Cell, 页码:496-497 , 文章类型: Editorial Material,,卷期:2011年9-6]
- Transplantation assays suggest that multipotent stem cells maintain the two lineages of the mammary gland. Recently in Nature, Van Keymeulen et al. (2011) used lineage tracing to discover unipotent stem cells that mainta...
- Induced Neuronal Cells: How to Make and Define a Neuron
[作者:Yang, N; Ng, YH; Pang, ZPP; Sudhof, TC; Wernig, M,期刊:Cell Stem Cell, 页码:517-525 , 文章类型: Review,,卷期:2011年9-6]
- Cellular plasticity is a major focus of investigation in developmental biology. The recent discovery that induced neuronal (iN) cells can be generated from mouse and human fibroblasts by expression of defined transcripti...
- Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin
[作者:Chong, JJH; Chandrakanthan, V; Xaymardan, M; Asli, NS; Li, J; Ahmed, I; Heffernan, C; Menon, MK; Scarlett, CJ; Rashidianfar, A; Biben, C; Zoellner, H; Colvin, EK; Pimanda, JE; Biankin, AV; Zhou, B; Pu, WT; Prall, OWJ; Harvey, RP,期刊:Cell Stem Cell, 页码:527-540 , 文章类型: Article,,卷期:2011年9-6]
- Colony-forming units fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs, although the relationship between BM and organ-specific CFU-Fs in ho...
- Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells
[作者:Chen, MJ; Li, Y; De Obaldia, ME; Yang, Q; Yzaguirre, AD; Yamada-Inagawa, T; Vink, CS; Bhandoola, A; Dzierzak, E; Speck, NA,期刊:Cell Stem Cell, 页码:541-552 , 文章类型: Article,,卷期:2011年9-6]
- Hematopoietic stem cells (HSCs) and an earlier wave of definitive erythroid/myeloid progenitors (EMPs) differentiate from hemogenic endothelial cells in the conceptus. EMPs can be generated in vitro from embryonic or ind...
- Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells
[作者:Elling, U; Taubenschmid, J; Wirnsberger, G; O'Malley, R; Demers, SP; Vanhaelen, Q; Shukalyuk, AI; Schmauss, G; Schramek, D; Schnuetgen, F; von Melchner, H; Ecker, JR; Stanford, WL; Zuber, J; Stark, A; Penninger, JM,期刊:Cell Stem Cell, 页码:563-574 , 文章类型: Article,,卷期:2011年9-6]
- All somatic mammalian cells carry two copies of chromosomes (diploidy), whereas organisms with a single copy of their genome, such as yeast, provide a basis for recessive genetics. Here we report the generation of haploi...
- The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner
[作者:Wang, T; Chen, KS; Zeng, XM; Yang, JG; Wu, Y; Shi, X; Qin, BM; Zeng, LW; Esteban, MA; Pan, GJ; Pei, DQ,期刊:Cell Stem Cell, 页码:575-587 , 文章类型: Article,,卷期:2011年9-6]
- Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) resets the epigenome to an embryonic-like state. Vitamin C enhances the reprogramming process, but the underlying mechanisms are unclear. Here we...
- Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells
[作者:Carey, BW; Markoulaki, S; Hanna, JH; Faddah, DA; Buganim, Y; Kim, J; Ganz, K; Steine, EJ; Cassady, JP; Creyghton, MP; Welstead, GG; Gao, Q; Jaenisch, R,期刊:Cell Stem Cell, 页码:588-598 , 文章类型: Article,,卷期:2011年9-6]
- We compared two genetically highly defined transgenic systems to identify parameters affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that the level and stoichiometry of reprogramm...
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