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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Philosophies of Funding [作者：O'Malley, MA; Elliott, KC; Haufe, C; Burian, RM,期刊：Cell, 页码：611-615 , 文章类型： Article，,卷期：2009年138-4] Successful scientific practice encompasses broader and more varied modes of investigation than can be captured by focusing on hypothesis-driven research. We examine the emphases that major US and UK funding agencies plac... iPS Cells: Insights into Basic Biology [作者：Ramalho-Santos, M,期刊：Cell, 页码：616-618 , 文章类型： Article，,卷期：2009年138-4] The discovery that adult somatic cells can be induced to become pluripotent by overexpression of a few key transcription factors provides an exciting new window into the basic biology of pluripotency and differentiation.... Only Two Ways to Achieve Perfection [作者：Artyukhin, AB; Wu, LF; Altschuler, SJ,期刊：Cell, 页码：619-621 , 文章类型： Article，,卷期：2009年138-4] The functional repertoire of a network is determined by its topology. Ma et al. (2009) analyze enzyme networks with three nodes and take a reverse-engineering approach to ask how many core network topologies can establis... Clamping down on Transposon Targeting [作者：Chandler, M,期刊：Cell, 页码：621-623 , 文章类型： Article，,卷期：2009年138-4] The sliding beta clamp subunit of the DNA replication machinery in the bacterium Escherichia coli coordinates multiple functions in the cell beyond genome duplication. In this issue, Parks et al. (2009) find that the bet... Breast Cancer Stem Cells: Eradication by Differentiation Therapy? [作者：Beug, H,期刊：Cell, 页码：623-625 , 文章类型： Article，,卷期：2009年138-4] During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-thr... Plant Phase Transitions Make a SPLash [作者：Fornara, F; Coupland, G,期刊：Cell, 页码：625-627 , 文章类型： Article，,卷期：2009年138-4] During post-embryonic development, plants undergo a series of phase transitions, from juvenile to adult and from the vegetative to the reproductive phase. Recent findings reported in Cell (Wang et al., 2009; Wu et al., 2... Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening [作者：Gupta, PB; Onder, TT; Jiang, GZ; Tao, K; Kuperwasser, C; Weinberg, RA; Lander, ES,期刊：Cell, 页码：645-659 , 文章类型： Article，,卷期：2009年138-4] Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe h... LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer [作者：Wang, Y; Zhang, H; Chen, YP; Sun, YM; Yang, F; Yu, WH; Liang, J; Sun, LY; Yang, XH; Shi, L; Li, RF; Li, YY; Zhang, Y; Li, Q; Yi, X; Shang, YF,期刊：Cell, 页码：660-672 , 文章类型： Article，,卷期：2009年138-4] Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal development and has been linked to several high-risk cancers. Here, we report that LSD1 is an integral component of the Mi-2/nucleosome remo... Widespread Shortening of 3 ' UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells [作者：Mayr, C; Bartel, DP,期刊：Cell, 页码：673-684 , 文章类型： Article，,卷期：2009年138-4] In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed without alteration of the proto-oncogene. H... Transposition into Replicating DNA Occurs through Interaction with the Processivity Factor [作者：Parks, AR; Li, ZP; Shi, QJ; Owens, RM; Jin, MM; Peters, JE,期刊：Cell, 页码：685-695 , 文章类型： Article，,卷期：2009年138-4] The bacterial transposon Tn7 directs transposition into actively replicating DNA by a mechanism involving the transposon-encoded protein TnsE. Here we show that TnsE physically and functionally interacts with the process... TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation [作者：Heo, I; Joo, C; Kim, YK; Ha, M; Yoon, MJ; Cho, J; Yeom, KH; Han, J; Kim, VN,期刊：Cell, 页码：696-708 , 文章类型： Article，,卷期：2009年138-4] As key regulators in cellular functions, microRNAs (miRNAs) themselves need to be tightly controlled. Lin28, a pluripotency factor, was reported to downregulate let-7 miRNA by inducing uridylation of let-7 precursor (pre... Synaptotagmin-Mediated Bending of the Target Membrane Is a Critical Step in Ca2+-Regulated Fusion [作者：Hui, EF; Johnson, CP; Yao, J; Dunning, FM; Chapman, ER,期刊：Cell, 页码：709-721 , 文章类型： Article，,卷期：2009年138-4] Decades ago it was proposed that exocytosis involves invagination of the target membrane, resulting in a highly localized site of contact between the bilayers destined to fuse. The vesicle protein synaptotagmin-I (syt... Nanog Is the Gateway to the Pluripotent Ground State [作者：Silva, J; Nichols, J; Theunissen, TW; Guo, G; van Oosten, AL; Barrandon, O; Wray, J; Yamanaka, S; Chambers, I; Smith, A,期刊：Cell, 页码：722-737 , 文章类型： Article，,卷期：2009年138-4] Pluripotency is generated naturally during mammalian development through formation of the epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell reprogramming. Here we present eviden... miR156-Regulated SPL Transcription Factors Define an Endogenous Flowering Pathway in Arabidopsis thaliana [作者：Wang, JW; Czech, B; Weigel, D,期刊：Cell, 页码：738-749 , 文章类型： Article，,卷期：2009年138-4] The FT gene integrates several external and endogenous cues controlling flowering, including information on day length. A complex of the mobile FT protein and the bZIP transcription factor FD in turn has a central role i... The Sequential Action of miR156 and miR172 Regulates Developmental Timing in Arabidopsis [作者：Wu, G; Park, MY; Conway, SR; Wang, JW; Weigel, D; Poethig, RS,期刊：Cell, 页码：750-759 , 文章类型： Article，,卷期：2009年138-4] The transition from the juvenile to the adult phase of shoot development in plants is accompanied by changes in vegetative morphology and an increase in reproductive potential. Here, we describe the regulatory mechanism ... Defining Network Topologies that Can Achieve Biochemical Adaptation [作者：Ma, WZ; Trusina, A; El-Samad, H; Lim, WA; Tang, C,期刊：Cell, 页码：760-773 , 文章类型： Article，,卷期：2009年138-4] Many signaling systems show adaptation-the ability to reset themselves after responding to a stimulus. We computationally searched all possible three-node enzyme network topologies to identify those that could perform ad...