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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共30条记录   Recent developments and biological activities of thiazolidinone derivatives: A review [作者：JAIN ABHISHEK KUMAR; VAIDYA ANKUR; RAVICHANDRAN VEERASAMY; KASHAW SUSHIL KUMAR; AGRAWAL RAM KISHORE,期刊：Bioorganic & Medicinal Chemistry, 页码：3378-3395 , 文章类型： Review，,卷期：2012年20-11] Thiazolidinone is considered as a biologically important active scaffold that possesses almost all types of biological activities. Successful introduction of ralitoline as a potent anti-convulsant, etozoline as a antihyp... N-4-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: Cytotoxicity against human tumor cells, structure-activity relationship studies and investigation on the mechanism of action [作者：SOARES MARCELLA A; LESSA JOSANE A; MENDES ISOLDA C; DA SILVA JEFERSON G; DOS SANTOS RAQUEL G; SALUM LIVIA B; DAGHESTANI HIKMAT; ANDRICOPULO ADRIANO D; DAY BILLY W; VOGT ANDREAS; PESQUERO JORGE L; ROCHA WILLIAN R; BERALDO HELOISA,期刊：Bioorganic & Medicinal Chemistry, 页码：3396-3409 , 文章类型： Article，,卷期：2012年20-11] N-4-Phenyl 2-acetylpyridine thiosemicarbazone (H2Ac4Ph; N-(phenyl)-2-(1-(pyridin-2-yl)ethylidene) hydrazinecarbothioamide) and its N-4-ortho-, -meta- and -para-fluorophenyl (H2Ac4oFPh, H2Ac4mFPh, H2Ac4pFPh), N-4-ortho-, ... Radiosynthesis of a F-18-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo [作者：KNIESS TORSTEN; LAUBE MARKUS; BERGMANN RALF; SEHN FABIAN; GRAF FRANZISKA; STEINBACH JOERG; WUEST FRANK; PIETZSCH JENS,期刊：Bioorganic & Medicinal Chemistry, 页码：3410-3421 , 文章类型： Article，,卷期：2012年20-11] The radiosynthesis of 3-(4-[F-18]fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-indole [F-18]-3 as potential PET radiotracer for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo is described. [F-... Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction [作者：JI CHENG; LIN WEIMIN; MORASKI GARRETT C; THANASSI JANE A; PUCCI MICHAEL J; FRANZBLAU SCOTT G; MOELLMANN UTE; MILLER MARVIN J,期刊：Bioorganic & Medicinal Chemistry, 页码：3422-3428 , 文章类型： Article，,卷期：2012年20-11] Several novel oxazolidinone antibiotics with a spiropiperazinyl substituent at the 4'-position of the phenyl ring were synthesized through nitroso Diels-Alder chemistry and the in vitro antibacterial activities were eval... Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists [作者：MARINOZZI MAURA; CAROTTI ANDREA; SANSONE EMANUELE; MACCHIARULO ANTONIO; ROSATELLI EMILIANO; SARDELLA ROCCALDO; NATALINI BENEDETTO; RIZZO GIOVANNI; ADORINI LUCIANO; PASSERI DANIELA; DE FRANCO FRANCESCA; PRUZANSKI MARK; PELLICCIARI ROBERTO,期刊：Bioorganic & Medicinal Chemistry, 页码：3429-3445 , 文章类型： Article，,卷期：2012年20-11] A virtual screening procedure was applied to the discovery of structurally diverse non-steroidal Farnesoid X Receptor (FXR) agonists. From 117 compounds selected by virtual screening, a total of 47 compounds were found t... Free energy calculations on the binding of novel thiolactomycin derivatives to E. coli fatty acid synthase I [作者：STEINBRECHER THOMAS; CASE DAVID A; LABAHN ANDREAS,期刊：Bioorganic & Medicinal Chemistry, 页码：3446-3453 , 文章类型： Article，,卷期：2012年20-11] Finding novel antibiotics to combat the rise of drug resistance in harmful bacteria is of enormous importance for human health. Computational drug design can be employed to aid synthetic chemists in the search for new po... Alstiphyllanines I-O, ajmaline type alkaloids from Alstonia macrophylla showing vasorelaxant activity [作者：ARAI HIROKO; ZAIMA KAZUMASA; MITSUTA ERIKA; TAMAMOTO HARUKA; SAITO AIKO; HIRASAWA YUSUKE; RAHMAN ABDUL; KUSUMAWATI IDHA; ZAINI NOOR CHOLIES; MORITA HIROSHI,期刊：Bioorganic & Medicinal Chemistry, 页码：3454-3459 , 文章类型： Article，,卷期：2012年20-11] Seven new ajmaline type alkaloids, alstiphyllanines I-O (1-7) were isolated from the leaves of Alstonia macrophylla together with six related alkaloids (8-13). Structures and stereochemistry of 1-7 were fully elucidated ... Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonist [作者：BAN SHINTARO; OYAMA TAKUJI; KASUGA JUNICHI; OHGANE KENJI; NISHIO YOSHINO; MORIKAWA KOSUKE; HASHIMOTO YUICHI; MIYACHI HIROYUKI,期刊：Bioorganic & Medicinal Chemistry, 页码：3460-3464 , 文章类型： Article，,卷期：2012年20-11] Based on X-ray crystallographic analysis of a peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonist complexed with human PPARs ligand binding domain (LBD), we previously reported the design and synth... Development of a new enzyme-responsive self-immolative spacer conjugate applicable to the controlled drug release [作者：JIN HUIJUAN; LU JING; WU XUE,期刊：Bioorganic & Medicinal Chemistry, 页码：3465-3469 , 文章类型： Article，,卷期：2012年20-11] A new self-immolative spacer conjugate based on a chemical adaptor unit aiming at controlled releasing drugs was designed and synthesized. It releases a fluorophore which was used as a model drug via a spontaneous cycliz... Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site [作者：ABE YUKIKO; NAKAGAWA OSAMU; YAMAGUCHI RIE; SASAKI SHIGEKI,期刊：Bioorganic & Medicinal Chemistry, 页码：3470-3479 , 文章类型： Article，,卷期：2012年20-11] DNA is continuously damaged by endogenous and exogenous factors such as oxidative stress or DNA alkylating agents. These damaged nucleobases are removed by DNA N-glycosylase and form apurinic/apyrimidinic sites (AP sites... Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents [作者：KAMAL AHMED; MALLAREDDY ADLA; SURESH PAIDAKULA; SHAIK THOKHIR B; NAYAK V LAKSHMA; KISHOR CHANDAN; SHETTI RAJESH V C R N C; RAO N SANKARA; TAMBOLI JAKI R; RAMAKRISHNA S; ADDLAGATTA ANTHONY,期刊：Bioorganic & Medicinal Chemistry, 页码：3480-3492 , 文章类型： Article，,卷期：2012年20-11] A series of chalcone-amidobenzothiazole conjugates (9a-k and 10a,b) have been synthesized and evaluated for their anticancer activity. All these compounds exhibited potent activity and the IC50 of two potential compounds... Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol [作者：CHO SUENGMOK; PARK JIHAE; PAE AE NIM; HAN DAESEOK; KIM DONGSOO; CHO NAMCHUL; NO KYOUNG TAI; YANG HYEJIN; YOON MINSEOK; LEE CHANGHO; SHIMIZU MAKOTO; BAEK NAMIN,期刊：Bioorganic & Medicinal Chemistry, 页码：3493-3501 , 文章类型： Article，,卷期：2012年20-11] Licorice (Glycyrrhiza glabra, GG) is one of the most frequently used herbal medicines worldwide, and its various biological activities have been widely studied. GG is reported to have neurological properties such as anti... Synthesis and evaluation of gamma-lactam analogs of PGE(2) as EP4 and EP2/EP4 agonists [作者：KAMBE TOHRU; MARUYAMA TORU; NAKAI YOSHIHIKO; OIDA HIROJI; MARUYAMA TAKAYUKI; ABE NOBUTAKA; NISHIURA AKIO; NAKAI HISAO; TODA MASAAKI,期刊：Bioorganic & Medicinal Chemistry, 页码：3502-3522 , 文章类型： Article，,卷期：2012年20-11] To identify topically effective EP4 agonists and EP2/EP4 dual agonists with excellent subtype selectivity, further optimization of the 16-phenyl omega-chain moiety of the gamma-lactam 5-thia prostaglandin E analog and th... Activity landscape modeling of PPAR ligands with dual-activity difference maps [作者：MENDEZLUCIO OSCAR; PEREZVILLANUEVA JAIME; CASTILLO RAFAEL; MEDINAFRANCO JOSE L,期刊：Bioorganic & Medicinal Chemistry, 页码：3523-3532 , 文章类型： Article，,卷期：2012年20-11] Activation of peroxisome proliferator-activated receptor (PPAR) subtypes offers a promising strategy for the treatment of diabetes mellitus and metabolic diseases. Selective and dual PPAR agonists have been developed and... Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives [作者：BARROS FRANCISCO W A; SILVA TERESINHA GONCALVES; DA ROCHA PITTA MARINA GALDINO; BEZERRA DANIEL P; COSTALOTUFO LETICIA V; DE MORAES MANOEL ODORICO; PESSOA CLAUDIA; DE MOURA MARIA ALINE F B; DE ABREU FABIANE C; ALVES DE LIMA MARIA DO CARMO; GALDINO SUELY LINS; PITTA IVAN DA ROCHA; GOULART MARILIA O F,期刊：Bioorganic & Medicinal Chemistry, 页码：3533-3539 , 文章类型： Article，,卷期：2012年20-11] Although their exact role in controlling tumour growth and apoptosis in humans remains undefined, acridine and thiazolidine compounds have been shown to act as tumour suppressors in most cancers. Based on this finding, a... An unusually cold active nitroreductase for prodrug activations [作者：CELIK AYHAN; YETIS GULDEN,期刊：Bioorganic & Medicinal Chemistry, 页码：3540-3550 , 文章类型： Article，,卷期：2012年20-11] A set of PCR primers based on the genome sequence were used to clone a gene encoding a hypothetical nitroreductases (named as Ssap-NtrB) from uropathogenic staphylococcus, Staphylococcus saprophyticus strain ATCC 15305, ...