- Tumors induce complex DNA damage in distant proliferative tissues in vivo
[作者:Redon, CE; Dickey, JS; Nakamura, AJ; Kareva, IG; Naf, D; Nowsheen, S; Kryston, TB; Bonner, WM; Georgakilas, AG; Sedelnikova, OA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17992-17997 , 文章类型: Article,,卷期:2010年107-42]
- That tumors cause changes in surrounding tissues is well documented, but whether they also affect distant tissues is uncertain. Such knowledge may be important in understanding the relationship between cancer and overall...
- Duration of antigen receptor signaling determines T-cell tolerance or activation
[作者:Katzman, SD; O'Gorman, WE; Villarino, AV; Gallo, E; Friedman, RS; Krummel, MF; Nolan, GP; Abbas, AK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18085-18090 , 文章类型: Article,,卷期:2010年107-42]
- The early events that determine the decision between lymphocyte tolerance and activation are not well-understood. Using a model of systemic self-antigen recognition by CD4(+) T cells, we show, using single-cell biochemic...
- Development of a highly efficacious vaccinia-based dual vaccine against smallpox and anthrax, two important bioterror entities
[作者:Merkel, TJ; Perera, PY; Kelly, VK; Verma, A; Llewellyn, ZN; Waldmann, TA; Mosca, JD; Perera, LP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18091-18096 , 文章类型: Article,,卷期:2010年107-42]
- Bioterrorism poses a daunting challenge to global security and public health in the 21st century. Variola major virus, the etiological agent of smallpox, and Bacillus anthracis, the bacterial pathogen responsible for ant...
- Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy
[作者:Konno, T; Chen, D; Wang, LB; Wakimoto, H; Teekakirikul, P; Nayor, M; Kawana, M; Eminaga, S; Gorham, JM; Pandya, K; Smithies, O; Naya, FJ; Olson, EN; Seidman, JG; Seidman, CE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18097-18102 , 文章类型: Article,,卷期:2010年107-42]
- Unknown molecular responses to sarcomere protein gene mutations account for pathologic remodeling in hypertrophic cardiomyopathy (HCM), producing myocyte growth and increased cardiac fibrosis. To determine if hypertrophi...
- Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension
[作者:Hadchouel, J; Soukaseum, C; Busst, C; Zhou, XO; Baudrie, V; Zurrer, T; Cambillau, M; Elghozi, JL; Lifton, RP; Loffing, J; Jeunemaitre, X,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18109-18114 , 文章类型: Article,,卷期:2010年107-42]
- Mutations in WNK1 and WNK4 lead to familial hyperkalemic hypertension (FHHt). Because FHHt associates net positive Na+ balance together with K+ and H+ renal retention, the identification of WNK1 and WNK4 led to a new par...
- Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models
[作者:Liu, HP; Patel, MR; Prescher, JA; Patsialou, A; Qian, DL; Lin, JH; Wen, S; Chang, YF; Bachmann, MH; Shimono, Y; Dalerba, P; Adorno, M; Lobo, N; Bueno, J; Dirbas, FM; Goswami, S; Somlo, G; Condeelis, J; Contag, CH; Gambhir, SS; Clarke, MF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18115-18120 , 文章类型: Article,,卷期:2010年107-42]
- To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models r...
- NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis
[作者:Zhang, M; Brewer, AC; Schroder, K; Santos, CXC; Grieve, DJ; Wang, MS; Anilkumar, N; Yu, B; Dong, XB; Walker, SJ; Brandes, RP; Shah, AM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18121-18126 , 文章类型: Article,,卷期:2010年107-42]
- Cardiac failure occurs when the heart fails to adapt to chronic stresses. Reactive oxygen species (ROS)-dependent signaling is implicated in cardiac stress responses, but the role of different ROS sources remains unclear...
- Electrical transport along bacterial nanowires from Shewanella oneidensis MR-1
[作者:El-Naggar, MY; Wanger, G; Leung, KM; Yuzvinsky, TD; Southam, G; Yang, J; Lau, WM; Nealson, KH; Gorby, YA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18127-18131 , 文章类型: Article,,卷期:2010年107-42]
- Bacterial nanowires are extracellular appendages that have been suggested as pathways for electron transport in phylogenetically diverse microorganisms, including dissimilatory metal-reducing bacteria and photosynthetic ...
- Bifidobacterium animalis subsp lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes
[作者:Veiga, P; Gallini, CA; Beal, C; Michaud, M; Delaney, ML; DuBois, A; Khlebnikov, A; Vlieg, JETV; Punit, S; Glickman, JN; Onderdonk, A; Glimcher, LH; Garrett, WS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18132-18137 , 文章类型: Article,,卷期:2010年107-42]
- Intestinal health requires the coexistence of eukaryotic self with the gut microbiota and dysregulated host-microbial interactions can result in intestinal inflammation. Here, we show that colitis improved in T-bet(-/-)R...
- Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function
[作者:Thompson, MA; Casolari, JM; Badieirostami, M; Brown, PO; Moerner, WE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17864-17871 , 文章类型: Article,,卷期:2010年107-42]
- Optical imaging of single biomolecules and complexes in living cells provides a useful window into cellular processes. However, the three-dimensional dynamics of most important biomolecules in living cells remains essent...
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