- Organocatalytic asymmetric assembly reactions for the syntheses of carbohydrate derivatives by intermolecular Michael-Henry reactions
[作者:Uehara, H; Imashiro, R; Hernandez-Torres, G; Barbas, CF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20672-20677 , 文章类型: Article,,卷期:2010年107-48]
- Given the significance of carbohydrates in life, medicine, and industry, the development of simple and efficient de novo methods to synthesize carbohydrates are highly desirable. Organocatalytic asymmetric assembly react...
- Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism
[作者:Zhu, BZ; Zhu, JG; Mao, L; Kalyanaraman, B; Shan, GQ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20686-20690 , 文章类型: Article,,卷期:2010年107-48]
- Hydroxamic acids, which are best-known for their metal-chelating properties in biomedical research, have been found to effectively detoxify the carcinogenic polyhalogenated quinoid metabolites of pentachlorophenol and ot...
- Measurement of adherent cell mass and growth
[作者:Park, K; Millet, LJ; Kim, N; Li, HA; Jin, XZ; Popescu, G; Aluru, NR; Hsia, KJ; Bashir, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20691-20696 , 文章类型: Article,,卷期:2010年107-48]
- The characterization of physical properties of cells such as their mass and stiffness has been of great interest and can have profound implications in cell biology, tissue engineering, cancer, and disease research. For e...
- Synchronized Northern Hemisphere climate change and solar magnetic cycles during the Maunder Minimum
[作者:Yamaguchi, YT; Yokoyama, Y; Miyahara, H; Sho, K; Nakatsuka, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20697-20702 , 文章类型: Article,,卷期:2010年107-48]
- The Maunder Minimum (A.D. 1645-1715) is a useful period to investigate possible sun-climate linkages as sunspots became exceedingly rare and the characteristics of solar cycles were different from those of today. Here, w...
- In silico investigation of intracranial blast mitigation with relevance to military traumatic brain injury
[作者:Nyein, MK; Jason, AM; Yu, L; Pita, CM; Joannopoulos, JD; Moore, DF; Radovitzky, RA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20703-20708 , 文章类型: Article,,卷期:2010年107-48]
- Blast-induced traumatic brain injury is the most prevalent military injury in Iraq and Afghanistan, yet little is known about the mechanical effects of blasts on the human head, and still less is known about how personal...
- Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability
[作者:Lee, W; Cho, NJ; Xiong, AM; Glenn, JS; Frank, CW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20709-20714 , 文章类型: Article,,卷期:2010年107-48]
- Cell encapsulating poly(ethylene glycol) hydrogels represent a promising approach for constructing 3D cultures designed to more closely approximate in vivo tissue environment. Improved strategies are needed, however, to ...
- Mechanism of replication blocking and bypass of Y-family polymerase eta by bulky acetylaminofluorene DNA adducts
[作者:Schorr, S; Schneider, S; Lammens, K; Hopfner, KP; Carell, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20720-20725 , 文章类型: Article,,卷期:2010年107-48]
- Heterocyclic aromatic amines produce bulky C8 guanine lesions in vivo, which interfere and disrupt DNA and RNA synthesis. These lesions are consequently strong replication blocks. In addition bulky adducts give rise to p...
- Cell-free fusion of bacteria-containing phagosomes with endocytic compartments
[作者:Becken, U; Jeschke, A; Veltman, K; Haas, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20726-20731 , 文章类型: Article,,卷期:2010年107-48]
- Uptake of microorganisms by professional phagocytic cells leads to formation of a new subcellular compartment, the phagosome, which matures by sequential fusion with early and late endocytic compartments, resulting in ox...
- Structure and folding of a designed knotted protein
[作者:King, NP; Jacobitz, AW; Sawaya, MR; Goldschmidt, L; Yeates, TO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20732-20737 , 文章类型: Article,,卷期:2010年107-48]
- A very small number of natural proteins have folded configurations in which the polypeptide backbone is knotted. Relatively little is known about the folding energy landscapes of such proteins, or how they have evolved. ...
- Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission
[作者:Van Prooyen, N; Gold, H; Andresen, V; Schwartz, O; Jones, K; Ruscetti, F; Lockett, S; Gudla, P; Venzon, D; Franchini, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20738-20743 , 文章类型: Article,,卷期:2010年107-48]
- The human T-cell leukemia virus type 1 (HTLV-1) is the cause of adult T-cell leukemia/lymphoma as well as tropical spastic paraparesis/HTLV-1-associated myelopathy. HTLV-1 is transmitted to T cells through the virologica...
- skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration
[作者:Park, CY; Pierce, SA; von Drehle, M; Ivey, KN; Morgan, JA; Blau, HM; Srivastava, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20750-20755 , 文章类型: Article,,卷期:2010年107-48]
- Cardiac and skeletal muscle development and maintenance require complex interactions between DNA-binding proteins and chromatin remodeling factors. We previously reported that Smyd1, a muscle-restricted histone methyltra...
- Most harmful algal bloom species are vitamin B-1 and B-12 auxotrophs
[作者:Tang, YZ; Koch, F; Gobler, CJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20756-20761 , 文章类型: Article,,卷期:2010年107-48]
- Eutrophication can play a central role in promoting harmful algal blooms (HABs), and therefore many HAB studies to date have focused on macronutrients (N, P, Si). Although a majority of algal species require exogenous B ...
- Toxic diatoms and domoic acid in natural and iron enriched waters of the oceanic Pacific
[作者:Silver, MW; Bargu, S; Coale, SL; Benitez-Nelson, CR; Garcia, AC; Roberts, KJ; Sekula-Wood, E; Bruland, KW; Coale, KH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20762-20767 , 文章类型: Article,,卷期:2010年107-48]
- Near-surface waters ranging from the Pacific subarctic (58 degrees N) to the Southern Ocean (66 degrees S) contain the neurotoxin domoic acid (DA), associated with the diatom Pseudo-nitzschia. Of the 35 stations sampled,...
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