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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共6条记录   siRNA Based Approaches in Medicinal Chemistry and Drug Discovery [作者：Schiffelers, RM,期刊：Current Topics in Medicinal Chemistry, 页码：67-68 , 文章类型： Editorial Material，,卷期：2012年12-2] RNA Interference-Mediated Validation of Survivin and Apollon/BRUCE as New Therapeutic Targets for Cancer Therapy [作者：Pennati, M; Millo, E; Gandellini, P; Folini, M; Zaffaroni, N,期刊：Current Topics in Medicinal Chemistry, 页码：69-78 , 文章类型： Review，,卷期：2012年12-2] The ability to evade apoptosis is one of the defining hallmarks of cancer. It enables the survival of cancer cells under abnormal growth stimulation and mediates their increased resistance to treatment with cytotoxic dru... Intracellular Localization and Routing of miRNA and RNAi Pathway Components [作者：Ohrt, T; Muetze, J; Svoboda, P; Schwille, P,期刊：Current Topics in Medicinal Chemistry, 页码：79-88 , 文章类型： Review，,卷期：2012年12-2] Several different pathways, generally termed RNA silencing pathways, utilize small RNA molecules guiding sequence-specific silencing effects of ribonucleoprotein effector complexes, traditionally termed RNA-induced silen... Matrix Systems for siRNA Delivery [作者：Naeye, B; Raemdonck, K; Remaut, K; Demeester, J; De Smedt, SC,期刊：Current Topics in Medicinal Chemistry, 页码：89-96 , 文章类型： Review，,卷期：2012年12-2] Over the last decade, considerable effort has been put in the implementation of RNA interference (RNAi) as a treatment for various disorders. As RNAi occurs in the cytoplasm of cells, it is imperative that RNAi mediators... siRNA Delivery with Lipid-based Systems: Promises and Pitfalls [作者：Foged, C,期刊：Current Topics in Medicinal Chemistry, 页码：97-107 , 文章类型： Review，,卷期：2012年12-2] A key hurdle for the further development of RNA interference (RNAi) therapeutics like small interfering RNA (siRNA) is their safe and effective delivery. Lipids are promising and versatile carriers because they are based... Polymeric Carrier Systems for siRNA Delivery [作者：Vader, P; van der Aa, LJ; Storm, G; Schiffelers, RM; Engbersen, JFJ,期刊：Current Topics in Medicinal Chemistry, 页码：108-119 , 文章类型： Review，,卷期：2012年12-2] RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRN...