- Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method
[作者:Li, L; Liu, LN; Feller, S; Allen, C; Shivakumar, R; Fratantoni, J; Wolfraim, LA; Fujisaki, H; Campana, D; Chopas, N; Dzekunov, S; Peshwa, M,期刊:Cancer gene therapy, 页码:147-154 , 文章类型: Article,,卷期:2010年17-3]
- Natural killer (NK) cells hold promise for cancer therapy. NK cytotoxicity can be enhanced by expression of chimeric antigen receptors that re-direct specificity toward target cells by engaging cell surface molecules exp...
- In vitro and in vivo delivery of novel anticancer fusion protein MULT1E/FasTI via adenoviral vectors
[作者:Kotturi, HSR; Li, J; Branham-O'Connor, M; Yu, X; Wagner, TE; Wei, Y,期刊:Cancer gene therapy, 页码:164-170 , 文章类型: Article,,卷期:2010年17-3]
- We previously demonstrated that a novel fusion protein MULT1E/FasTI expressed by TC-1 tumor cells inhibited tumor growth by simultaneously activating NKG2D expressing cells, such as NK cells, through the MULT1E portion a...
- Inhibition of tumor growth and induction of apoptosis in prostate cancer cell lines by overexpression of tissue inhibitor of matrix metalloproteinase-3
[作者:Zhang, L; Zhao, L; Zhao, D; Lin, G; Guo, B; Li, Y; Liang, Z; Zhao, XJ; Fang, X,期刊:Cancer gene therapy, 页码:171-179 , 文章类型: Article,,卷期:2010年17-3]
- The destruction of extracellular matrix by matrix metalloproteinases is a key event in cancer progression. The tissue inhibitors of metalloproteinases can restrain tumor growth by inhibiting these enzymes. We sought to d...
- Antitumor activity of Ad-IU2, a prostate-specific replication-competent adenovirus encoding the apoptosis inducer, TRAIL
[作者:Jimenez, JA; Li, X; Zhang, YP; Bae, KH; Mohammadi, Y; Pandya, P; Kao, C; Gardner, TA,期刊:Cancer gene therapy, 页码:180-191 , 文章类型: Article,,卷期:2010年17-3]
- In this study, we analyzed the preclinical utility and antitumor efficacy of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) delivered by Ad-IU2, a prostate-specific replication-competent adenovirus (PSRC...
- The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells
[作者:Huang, Q; Liu, XZ; Kang, CS; Wang, GX; Zhong, Y; Pu, PY,期刊:Cancer gene therapy, 页码:192-202 , 文章类型: Article,,卷期:2010年17-3]
- The disseminated neoplastic foci of malignant gliomas are essentially responsible for the limited efficacy of current available therapeutic modalities. Bone marrow-derived stem cells (BMSCs) have the ability to migrate i...
- An HDAC inhibitor enhances the antitumor activity of a CMV promoter-driven DNA vaccine
[作者:Lai, MD; Chen, CS; Yang, CR; Yuan, SY; Tsai, JJ; Tu, CF; Wang, CC; Yen, MC; Lin, CC,期刊:Cancer gene therapy, 页码:203-211 , 文章类型: Article,,卷期:2010年17-3]
- The cytomegalovirus (CMV) promoter is considered to be one of the strongest promoters for driving the in vivo expression of genes encoded by DNA vaccines. However, the efficacy of DNA vaccines has so far been disappointi...
- Silencing of HIF-1 alpha suppresses tumorigenicity of renal cell carcinoma through induction of apoptosis
[作者:Xu, K; Ding, Q; Fang, Z; Zheng, J; Gao, P; Lu, Y; Zhang, Y,期刊:Cancer gene therapy, 页码:212-222 , 文章类型: Article,,卷期:2010年17-3]
- Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a main responder to intracellular hypoxia and is overexpressed in many human cancers, including renal cell carcinoma (RCC). To better understanding of the role of HIF-1 a...
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