- The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer
[作者:Yu, J; Cao, Q; Yu, J; Wu, L; Dallol, A; Li, J; Chen, G; Grasso, C; Cao, X; Lonigro, RJ; Varambally, S; Mehra, R; Palanisamy, N; Wu, JY; Latif, F; Chinnaiyan, AM,期刊:Oncogene, 页码:5370-5380 , 文章类型: Article,,卷期:2010年29-39]
- The neuronal repellent SLIT2 is repressed in a number of cancer types primarily through promoter hypermethylation. SLIT2, however, has not been studied in prostate cancer. Through genome-wide location analysis we identif...
- The BH3-only protein Bad confers breast cancer taxane sensitivity through a nonapoptotic mechanism
[作者:Craik, AC; Veldhoen, RA; Czernick, M; Buckland, TW; Kyselytzia, K; Ghosh, S; Lai, R; Damaraju, S; Underhill, DA; Mackey, JR; Goping, IS,期刊:Oncogene, 页码:5381-5391 , 文章类型: Article,,卷期:2010年29-39]
- Antimitotic agents such as taxanes (paclitaxel and docetaxel) have greatly advanced the treatment of breast cancer, although variable patient response and drug toxicity are major limitations. Lack of validated predictive...
- The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo
[作者:Merdzhanova, G; Gout, S; Keramidas, M; Edmond, V; Coll, JL; Brambilla, C; Brambilla, E; Gazzeri, S; Eymin, B,期刊:Oncogene, 页码:5392-5403 , 文章类型: Article,,卷期:2010年29-39]
- The transcription factor E2F1 has a crucial role in the control of cell growth and has been shown to regulate neoangiogenesis in a p53-dependent manner through inhibition of activity of the VEGF-A (vascular endothelial g...
- RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma
[作者:Zhang, Y; Jiang, X; Qin, X; Ye, D; Yi, Z; Liu, M; Bai, O; Liu, W; Xie, X; Wang, Z; Fang, J; Chen, Y,期刊:Oncogene, 页码:5404-5415 , 文章类型: Article,,卷期:2010年29-39]
- Vascular endothelial growth factors (VEGFs) are crucial regulators of angiogenesis and vasculogenesis. The autocrine VEGF signaling is required for maintaining the homeostasis of vasculature. Dysregulation of angiogenesi...
- Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP beta/zeta signaling by menin
[作者:Feng, ZJ; Gao, SB; Wu, Y; Xu, XF; Hua, X; Jin, GH,期刊:Oncogene, 页码:5416-5426 , 文章类型: Article,,卷期:2010年29-39]
- Menin encoded by the multiple endocrine neoplasia type 1 (MEN1) gene is associated with chromatin and the nuclear matrix and exerts multiple biological functions including regulation of cell proliferation and adhesion. M...
- Phosphorylated p68 RNA helicase activates snail1 transcription by promoting HDAC1 dissociation from the snail1 promoter
[作者:Carter, CL; Lin, C; Liu, CY; Yang, L; Liu, ZR,期刊:Oncogene, 页码:5427-5436 , 文章类型: Article,,卷期:2010年29-39]
- The nuclear p68 RNA helicase is a prototypical member of the DEAD-box family of RNA helicases. p68 RNA helicase has been implicated in cell proliferation and early organ development and maturation. However, the functiona...
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