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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Allostery and the dynamic oligomerization of porphobilinogen synthase [作者：Jaffe, EK; Lawrence, SH,期刊：Archives of Biochemistry and Biophysics , 页码：144-153 , 文章类型： Review，,卷期：2012年519-2] The structural basis for allosteric regulation of porphobilinogen synthase (PBGS) is modulation of a quaternary structure equilibrium between octamer and hexamer (via dimers), which is represented schematically as 8mer <... Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex [作者：Dunn, MF,期刊：Archives of Biochemistry and Biophysics , 页码：154-166 , 文章类型： Review，,卷期：2012年519-2] The tryptophan synthase alpha(2)beta(2) bi-enzyme complex catalyzes the last two steps in the synthesis of L-tryptophan (L-Trp). The alpha-subunit catalyzes cleavage of 3-indole-D-glycerol 3'-phosphate (IGP) to give indo... Allosteric regulation in Acetohydroxyacid Synthases (AHASs) - Different structures and kinetic behavior in isozymes in the same organisms [作者：Barak, Z; Chipman, DM,期刊：Archives of Biochemistry and Biophysics , 页码：167-174 , 文章类型： Review，,卷期：2012年519-2] Acetohydroxyacid Synthases (AHASs) have separate small regulatory subunits which specifically activate the catalytic subunits with which they are associated. The binding sites for the inhibitory amino acid(s) (valine or ... Contrasting catalytic and allosteric mechanisms for phosphoglycerate dehydrogenases [作者：Grant, GA,期刊：Archives of Biochemistry and Biophysics , 页码：175-185 , 文章类型： Review，,卷期：2012年519-2] D-3-Phosphoglycerate dehydrogenases (PGDH) exist with at least three different structural motifs and the enzymes from different species display distinctly different mechanisms. In many species, particularly bacteria, the... The many faces of aspartate kinases [作者：Dumas, R; Cobessi, D; Robin, AY; Ferrer, JL; Curien, G,期刊：Archives of Biochemistry and Biophysics , 页码：186-193 , 文章类型： Review，,卷期：2012年519-2] Based on recent X-ray structures and biochemical characterizations of aspartate kinases from different species, we show in this review how various organizations of a regulatory domain have contributed to the different me... Allosteric regulation of phenylalanine hydroxylase [作者：Fitzpatrick, PF,期刊：Archives of Biochemistry and Biophysics , 页码：194-201 , 文章类型： Review，,卷期：2012年519-2] The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physi... Structural and functional characterization of alpha-isopropylmalate synthase and citramalate synthase, members of the LeuA dimer superfamily [作者：Frantom, PA,期刊：Archives of Biochemistry and Biophysics , 页码：202-209 , 文章类型： Review，,卷期：2012年519-2] The manipulation of modular regulatory domains from allosteric enzymes represents a possible mechanism to engineer allostery into non-allosteric systems. Currently, there is insufficient understanding of the structure/fu... Metal site occupancy and allosteric switching in bacterial metal sensor proteins [作者：Guerra, AJ; Giedroc, DP,期刊：Archives of Biochemistry and Biophysics , 页码：210-222 , 文章类型： Review，,卷期：2012年519-2] All prokaryotes encode a panel of metal sensor or metalloregulatory proteins that govern the expression of genes that allows an organism to quickly adapt to toxicity or deprivation of both biologically essential transiti... NMR insights into protein allostery [作者：Manley, G; Loria, JP,期刊：Archives of Biochemistry and Biophysics , 页码：223-231 , 文章类型： Review，,卷期：2012年519-2] Allosterism is one of nature's principal methods for regulating protein function. Allosterism utilizes ligand binding at one site to regulate the function of the protein by modulating the structure and dynamics of a dist... Special Issue: Allosteric Regulation Introduction [作者：Grant, GA,期刊：Archives of Biochemistry and Biophysics , 页码：67-68 , 文章类型： Editorial Material，,卷期：2012年519-2] The structure and allosteric regulation of mammalian glutamate dehydrogenase [作者：Li, M; Li, CH; Allen, A; Stanley, CA; Smith, TJ,期刊：Archives of Biochemistry and Biophysics , 页码：69-80 , 文章类型： Review，,卷期：2012年519-2] Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of L-glutamate to 2-oxoglutarate. Only in the animal kingdom is this enzyme heavily allosterically regulated by ... Allostery and cooperativity in Escherichia coli aspartate transcarbamoylase [作者：Kantrowitz, ER,期刊：Archives of Biochemistry and Biophysics , 页码：81-90 , 文章类型： Review，,卷期：2012年519-2] The allosteric enzyme aspartate transcarbamoylase (ATCase) from Escherichia coil has been the subject of investigations for approximately 50 years. This enzyme controls the rate of pyrimidine nucleotide biosynthesis by f... A novel type of allosteric regulation: Functional cooperativity in monomeric proteins [作者：Denisov, IG; Sligar, SG,期刊：Archives of Biochemistry and Biophysics , 页码：91-102 , 文章类型： Review，,卷期：2012年519-2] Cooperative functional properties and allosteric regulation in cytochromes P450 play an important role in xenobiotic metabolism and define one of the main mechanisms of drug-drug interactions. Recent experimental results... Homotropic allosteric regulation in monomeric mammalian glucokinase [作者：Larion, M; Miller, BG,期刊：Archives of Biochemistry and Biophysics , 页码：103-111 , 文章类型： Review，,卷期：2012年519-2] Glucokinase catalyzes the ATP-dependent phosphorylation of glucose, a chemical transformation that represents the rate-limiting step of glycolytic metabolism in the liver and pancreas. Glucokinase is a central regulator ... Ligand binding and structural changes associated with allostery in yeast NAD(+)-specific isocitrate dehydrogenase [作者：McAlister-Henn, L,期刊：Archives of Biochemistry and Biophysics , 页码：112-117 , 文章类型： Article，,卷期：2012年519-2] Yeast NAD(+)-specific isocitrate dehydrogenase (IDH) is an octameric enzyme composed of four each of regulatory IDH1 and catalytic IDH2 subunits that share 42% sequence identity. IDH2 contains catalytic isocitrate/Mg2+ a... Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA [作者：Adina-Zada, A; Zeczycki, TN; Attwood, PV,期刊：Archives of Biochemistry and Biophysics , 页码：118-130 , 文章类型： Review，,卷期：2012年519-2] In this review we examine the effects of the allosteric activator, acetyl CoA on both the structure and catalytic activities of pyruvate carboxylase. We describe how the binding of acetyl CoA produces gross changes to th...