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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共66条记录   Apolipoprotein E Promotes beta-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels [作者：Lee, CYD; Tse, W; Smith, JD; Landreth, GE,期刊：Journal of Biological Chemistry, 页码：2032-2044 , 文章类型： Article，,卷期：2012年287-3] Allelic variation in the apolipoprotein E (APOE) gene is the major risk factor of sporadic Alzheimer disease. ApoE is the primary cholesterol carrier in the brain. Previously, we demonstrated that intracellular degradati... Novel Mechanism for Fc epsilon RI-mediated Signal Transducer and Activator of Transcription 5 (STAT5) Tyrosine Phosphorylation and the Selective Influence of STAT5B over Mast Cell Cytokine Production [作者：Pullen, NA; Barnstein, BO; Falanga, YT; Wang, ZQ; Suzuki, R; Tamang, TDL; Khurana, MC; Harry, EA; Draber, P; Bunting, KD; Mizuno, K; Wilson, BS; Ryan, JJ,期刊：Journal of Biological Chemistry, 页码：2045-2054 , 文章类型： Article，,卷期：2012年287-3] Previous studies indicate that STAT5 expression is required for mast cell development, survival, and IgE-mediated function. STAT5 tyrosine phosphorylation is swiftly and transiently induced by activation of the high affi... Disruption of Kv1.3 Channel Forward Vesicular Trafficking by Hypoxia in Human T Lymphocytes [作者：Chimote, AA; Kuras, Z; Conforti, L,期刊：Journal of Biological Chemistry, 页码：2055-2067 , 文章类型： Article，,卷期：2012年287-3] Hypoxia in solid tumors contributes to decreased immunosurveillance via down-regulation of Kv1.3 channels in T lymphocytes and associated T cell function inhibition. However, the mechanisms responsible for Kv1.3 down-reg... Polyglutamine Expansion Alters the Dynamics and Molecular Architecture of Aggregates in Dentatorubropallidoluysian Atrophy [作者：Hinz, J; Lehnhardt, L; Zakrzewski, S; Zhang, G; Ignatova, Z,期刊：Journal of Biological Chemistry, 页码：2068-2078 , 文章类型： Article，,卷期：2012年287-3] Preferential accumulation of mutant proteins in the nucleus has been suggested to be the molecular culprit that confers cellular toxicity in the neurodegenerative disorders caused by polyglutamine (polyQ) expansion. Here... Hydrolysis of Secreted Sialoglycoprotein Immunoglobulin A (IgA) in ex Vivo and Biochemical Models of Bacterial Vaginosis [作者：Lewis, WG; Robinson, LS; Perry, J; Bick, JL; Peipert, JF; Allsworth, JE; Lewis, AL,期刊：Journal of Biological Chemistry, 页码：2079-2089 , 文章类型： Article，,卷期：2012年287-3] Bacterial vaginosis (BV) is a common polymicrobial imbalance of the vaginal flora associated with a wide variety of obstetric and gynecologic complications including serious infections and preterm birth. As evidenced by ... Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation [作者：Fang, Z; Zhang, T; Dizeyi, N; Chen, S; Wang, HY; Swanson, KD; Cai, CM; Balk, SP; Yuan, X,期刊：Journal of Biological Chemistry, 页码：2090-2098 , 文章类型： Article，,卷期：2012年287-3] Androgen receptor (AR) plays a central role in prostate cancer (PCa) growth, with androgen deprivation or AR down-regulation causing cell-cycle arrest and accumulation of the p27 cyclin-dependent kinase inhibitor. The mo... V2 Vasopressin Receptor (V2R) Mutations in Partial Nephrogenic Diabetes Insipidus Highlight Protean Agonism of V2R Antagonists [作者：Takahashi, K; Makita, N; Manaka, K; Hisano, M; Akioka, Y; Miura, K; Takubo, N; Iida, A; Ueda, N; Hashimoto, M; Fujita, T; Igarashi, T; Sekine, T; Iiri, T,期刊：Journal of Biological Chemistry, 页码：2099-2106 , 文章类型： Article，,卷期：2012年287-3] Inactivating mutations of the V2 vasopressin receptor (V2R) cause cross-linked congenital nephrogenic diabetes insipidus (NDI), resulting in renal resistance to the antidiuretic hormone AVP. In two families showing parti... Zinc Finger Protein ZFP57 Requires Its Co-factor to Recruit DNA Methyltransferases and Maintains DNA Methylation Imprint in Embryonic Stem Cells via Its Transcriptional Repression Domain [作者：Zuo, XP; Sheng, JP; Lau, HT; McDonald, CM; Andrade, M; Cullen, DE; Bell, FT; Iacovino, M; Kyba, M; Xu, GL; Li, XJ,期刊：Journal of Biological Chemistry, 页码：2107-2118 , 文章类型： Article，,卷期：2012年287-3] Previously, we discovered that ZFP57 is a maternal-zygotic effect gene, and it maintains DNA methylation genomic imprint at multiple imprinted regions in mouse embryos. Despite these findings, it remains elusive how DNA ... Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates [作者：Egger, S; Chaikuad, A; Klimacek, M; Kavanagh, KL; Oppermann, U; Nidetzky, B,期刊：Journal of Biological Chemistry, 页码：2119-2129 , 文章类型： Article，,卷期：2012年287-3] Biosynthesis of UDP-glucuronic acid by UDP-glucose 6-dehydrogenase (UGDH) occurs through the four-electron oxidation of the UDP-glucose C6 primary alcohol in two NAD(+)-dependent steps. The catalytic reaction of UGDH is ... Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification [作者：Pastore, C; Topalidou, I; Forouhar, F; Yan, AC; Levy, M; Hunt, JF,期刊：Journal of Biological Chemistry, 页码：2130-2143 , 文章类型： Article，,卷期：2012年287-3] Humans express nine paralogs of the bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dioxygenase that reverses alkylation damage to nucleobases. The biochemical and physiological roles of these paralogs... Interferon-gamma Alters Downstream Signaling Originating from Epidermal Growth Factor Receptor in Intestinal Epithelial Cells FUNCTIONAL CONSEQUENCES FOR ION TRANSPORT [作者：Paul, G; Marchelletta, RR; McCole, DF; Barrett, KE,期刊：Journal of Biological Chemistry, 页码：2144-2155 , 文章类型： Article，,卷期：2012年287-3] The epidermal growth factor receptor (EGFr) regulates many cellular functions, such as proliferation, apoptosis, and ion transport. Our aim was to investigate whether long term treatment with interferon-gamma (IFN-gamma)... Generation and Functional Characterization of Knock-in Mice Harboring the Cardiac Troponin I-R21C Mutation Associated with Hypertrophic Cardiomyopathy [作者：Wang, YC; Pinto, JR; Solis, RS; Dweck, D; Liang, JS; Diaz-Perez, Z; Ge, Y; Walker, JW; Potter, JD,期刊：Journal of Biological Chemistry, 页码：2156-2167 , 文章类型： Article，,卷期：2012年287-3] The R21C substitution in cardiac troponin I (cTnI) is the only identified mutation within its unique N-terminal extension that is associated with hypertrophic cardiomyopathy (HCM) in man. Particularly, this mutation is l... Thematic Minireview Series on Focus on Vision [作者：Palczewski, K,期刊：Journal of Biological Chemistry, 页码：1610-1611 , 文章类型： Editorial Material，,卷期：2012年287-3] Chemistry and Biology of Vision [作者：Palczewski, K,期刊：Journal of Biological Chemistry, 页码：1612-1619 , 文章类型： Review，,卷期：2012年287-3] Visual perception in humans occurs through absorption of electromagnetic radiation from 400 to 780 nm by photoreceptors in the retina. A photon of visible light carries a sufficient amount of energy to cause, when absorb... Engagement of alpha IIb beta 3 (GPIIb/IIIa) with alpha nu beta 3 Integrin Mediates Interaction of Melanoma Cells with Platelets A CONNECTION TO HEMATOGENOUS METASTASIS [作者：Lonsdorf, AS; Kramer, BF; Fahrleitner, M; Schonberger, T; Gnerlich, S; Ring, S; Gehring, S; Schneider, SW; Kruhlak, MJ; Meuth, SG; Nieswandt, B; Gawaz, M; Enk, AH; Langer, HF,期刊：Journal of Biological Chemistry, 页码：2168-2178 , 文章类型： Article，,卷期：2012年287-3] A mutual relationship exists between metastasizing tumor cells and components of the coagulation cascade. The exact mechanisms as to how platelets influence blood-borne metastasis, however, remain poorly understood. Here... Structure-based Analysis of VDAC1 Protein DEFINING OLIGOMER CONTACT SITES [作者：Geula, S; Naveed, H; Liang, J; Shoshan-Barmatz, V,期刊：Journal of Biological Chemistry, 页码：2179-2190 , 文章类型： Article，,卷期：2012年287-3] The outer mitochondrial membrane protein, the voltage-dependent anion channel (VDAC), is increasingly implicated in the control of apoptosis. Oligomeric assembly of VDAC1 was shown to be coupled to apoptosis induction, w...