- NMD: RNA biology meets human genetic medicine
[作者:Bhuvanagiri, M; Schlitter, AM; Hentze, MW; Kulozik, AE,期刊:Biochemical Journal, 页码:365-377 , 文章类型: Review,,卷期:2010年430-Part 3]
- NMD (nonsense-mediated mRNA decay) belongs to the best-studied mRNA surveillance systems of the cell, limiting the synthesis of truncated and potentially harmful proteins on the one hand and playing an initially unexpect...
- Functional diversity of the hnRNPs: past, present and perspectives
[作者:Han, SP; Tang, YH; Smith, R,期刊:Biochemical Journal, 页码:379-392 , 文章类型: Review,,卷期:2010年430-Part 3]
- The hnRNPs (heterogeneous nuclear ribonucleoproteins) are RNA-binding proteins with important roles in multiple aspects of nucleic acid metabolism, including the packaging of nascent transcripts, alternative splicing and...
- 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
[作者:Nichols, RJ; Dzamko, N; Morrice, NA; Campbell, DG; Deak, M; Ordureau, A; Macartney, T; Tong, YR; Shen, J; Prescott, AR; Alessi, DR,期刊:Biochemical Journal, 页码:393-404 , 文章类型: Article,,卷期:2010年430-Part 3]
- LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of Parkinson's disease patients, but still little is understood about how it is regulated or functions. In the present study we have demonst...
- Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization
[作者:Dzamko, N; Deak, M; Hentati, F; Reith, AD; Prescott, AR; Alessi, DR; Nichols, RJ,期刊:Biochemical Journal, 页码:405-413 , 文章类型: Article,,卷期:2010年430-Part 3]
- LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of Parkinson's disease patients. Since a common mutation that replaces Gly(2019) with a serine residue enhances kinase catalytic activity, s...
- Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta 5-subunit
[作者:Blackburn, C; Gigstad, KM; Hales, P; Garcia, K; Jones, M; Bruzzese, FJ; Barrett, C; Liu, JX; Soucy, TA; Sappal, DS; Bump, N; Olhava, EJ; Fleming, P; Dick, LR; Tsu, C; Sintchak, MD; Blank, JL,期刊:Biochemical Journal, 页码:461-476 , 文章类型: Article,,卷期:2010年430-Part 3]
- The mammalian 26S proteasome is a 2500 kDa multi-catalytic complex involved in intracellular protein degradation. We describe the synthesis and properties of a novel series of non-covalent di-peptide inhibitors of the pr...
- The hydrophobic core region governs mutant prion protein aggregation and intracellular retention
[作者:Biasini, E; Tapella, L; Restelli, E; Pozzoli, M; Massignan, T; Chiesa, R,期刊:Biochemical Journal, 页码:477-486 , 文章类型: Article,,卷期:2010年430-Part 3]
- Approx. 15% of human prion diseases have a pattern of autosomal dominant inheritance, and are linked to mutations in the gene encoding PrP (prion protein), a GPI (glycosylphosphatidylinositol)-anchored protein whose func...
- Determinants of activity in glutaredoxins: an in vitro evolved Grx1-like variant of Escherichia coli Grx3
[作者:Elgan, TH; Planson, AG; Beckwith, J; Guntert, P; Berndt, KD,期刊:Biochemical Journal, 页码:487-495 , 文章类型: Article,,卷期:2010年430-Part 3]
- The Escherichia coil glutaredox ins 1 and 3 (Grx 1 and Grx3) are structurally similar (37 % sequence identity), yet have different activities in vivo. Unlike Grx3, Grx 1 efficiently reduces protein disulfides in proteins...
- Zn(II) ions co-secreted with insulin suppress inherent amyloidogenic properties of monomeric insulin
[作者:Noormagi, A; Gavrilova, J; Smirnova, J; Tougu, V; Palumaa, P,期刊:Biochemical Journal, 页码:511-518 , 文章类型: Article,,卷期:2010年430-Part 3]
- Insulin, a 51-residue peptide hormone, is an intrinsically amyloidogenic peptide, forming amyloid fibrils in vitro. In the secretory granules, insulin is densely packed together with Zn(II) into crystals of Zn(2)Insulin(...
- Extensive sphingolipid depletion does not affect lipid raft integrity or lipid raft localization and efflux function of the ABC transporter MRP1
[作者:Klappe, K; Dijkhuis, AJ; Hummel, I; van Dam, A; Ivanova, PT; Milne, SB; Myers, DS; Brown, HA; Permentier, H; Kok, JW,期刊:Biochemical Journal, 页码:519-529 , 文章类型: Article,,卷期:2010年430-Part 3]
- We show that highly efficient depletion of sphingolipids in two different cell lines does not abrogate the ability to isolate Lubrol-based DRMs (detergent-resistant membranes) or detergent-free lipid rafts from these cel...
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