- Biochemical and thermodynamic characterization of mutated beta 1,4-galactosyltransferase 7 involved in the progeroid form of the Ehlers-Danlos syndrome
[作者:Rahuel-Clermont, S; Daligault, F; Piet, MH; Gulberti, S; Netter, P; Branlant, G; Magdalou, J; Lattard, V,期刊:Biochemical Journal, 页码:303-311 , 文章类型: Article,,卷期:2010年432-Part 2]
- Three mutations of the B4GALT7 gene [encoding beta 1,4-GalT7 (beta 1,4-galactosyltransferase 7)], corresponding to A186D, L206P and R270C, have been identified in patients with the progeroid form of the Ehlers-Danlos syn...
- Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3
[作者:Peskin, AV; Cox, AG; Nagy, P; Morgan, PE; Hampton, MB; Davies, MJ; Winterbourn, CC,期刊:Biochemical Journal, 页码:313-321 , 文章类型: Article,,卷期:2010年432-Part 2]
- Prxs (peroxiredoxins) are a ubiquitous family of cysteine-dependent peroxidases that react rapidly with H2O2 and alkyl hydroperoxides and provide defence against these reactive oxidants. Hydroperoxides are also formed on...
- Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions
[作者:Gaikwad, AB; Gupta, J; Tikoo, K,期刊:Biochemical Journal, 页码:333-341 , 文章类型: Article,,卷期:2010年432-Part 2]
- Little is known regarding the role of hyperglycaemia on histone H3 modifications and, in turn, altering the expression of genes during the development of diabetes-associated complications. In the present study, we have i...
- Natural occurrence and physiological role of a truncated eIF4E in the porcine endometrium during implantation
[作者:Wollenhaupt, K; Reinke, K; Brussow, KP; Albrecht, D; Tiemann, U; Seyfert, HM; Tomek, W,期刊:Biochemical Journal, 页码:353-363 , 文章类型: Article,,卷期:2010年432-Part 2]
- The present study is the first report providing evidence for a physiological role of a truncated form of the mRNA cap-binding protein eIF4E1 (eukaryotic initiation factor 4E1). Our initial observation was that eIF4E, whi...
- Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C
[作者:Ullan, RV; Teijeira, F; Guerra, SM; Vaca, I; Martin, JF,期刊:Biochemical Journal, 页码:227-236 , 文章类型: Article,,卷期:2010年432-Part 2]
- The mechanisms of compartmentalization of intermediates and secretion of penicillins and cephalosporins in beta-lactam antibiotic-producing fungi are of great interest. In Acremonium chrysogenum, there is a compartmental...
- Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor alpha (LXR alpha) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1
[作者:Grefhorst, A; Schreurs, M; Oosterveer, MH; Cortes, VA; Havinga, R; Herling, AW; Reijngoud, DJ; Groen, AK; Kuipers, F,期刊:Biochemical Journal, 页码:249-254 , 文章类型: Article,,卷期:2010年432-Part 2]
- GSD-1 (glycogen storage disease type 1) is caused by an inherited defect in glucose-6-phosphatase activity, resulting in a massive accumulation of hepatic glycogen content and an induction of de novo lipogenesis. The chl...
- Transforming JAK1 mutations exhibit differential signalling, FERM domain requirements and growth responses to interferon-gamma
[作者:Gordon, GM; Lambert, QT; Daniel, KG; Reuther, GW,期刊:Biochemical Journal, 页码:255-265 , 文章类型: Article,,卷期:2010年432-Part 2]
- Recent work has highlighted roles for JAK (Janus kinase) family members in haemopoietic diseases. Although sequencing efforts have uncovered transforming JAK1 mutations in acute leukaemia, they have also identified non-t...
- Guanylate cyclase-G, expressed in the Grueneberg ganglion olfactory subsystem, is activated by bicarbonate
[作者:Chao, YC; Cheng, CJ; Hsieh, HT; Lin, CC; Chen, CC; Yang, RB,期刊:Biochemical Journal, 页码:267-273 , 文章类型: Article,,卷期:2010年432-Part 2]
- GC (guanylate cyclase)-G is the most recently identified member of the receptor GC family. However, the regulation of its activity and protein expression in the mammalian olfactory system remains unclear. In the present ...
- AHSP (alpha-haemoglobin-stabilizing protein) stabilizes apo-alpha-haemoglobin in a partially folded state
[作者:Kumar, KK; Dickson, CF; Weiss, MJ; Mackay, JP; Gell, DA,期刊:Biochemical Journal, 页码:275-282 , 文章类型: Article,,卷期:2010年432-Part 2]
- To produce functional Hb (haemoglobin), nascent a-globin (alpha(o)) and beta-globin (beta(o)) chains must each bind a single haem molecule (to form alpha(h) and beta(h)) and interact together to form heterodimers. The pr...
- Chelation of lysosomal iron protects against ionizing radiation
[作者:Berndt, C; Kurz, T; Seleniuss, M; Fernandes, AP; Edgren, MR; Brunk, UT,期刊:Biochemical Journal, 页码:295-301 , 文章类型: Article,,卷期:2010年432-Part 2]
- Ionizing radiation causes DNA damage and consequent apoptosis, mainly due to the production of hydroxyl radicals (HO center dot) that follows radiolytic splitting of water. However, superoxide (O-2(center dot-)) and H2O2...
- Plasmin on adherent cells: from microvesiculation to apoptosis
[作者:Doeuvre, L; Plawinski, L; Goux, D; Vivien, D; Angles-Cano, E,期刊:Biochemical Journal, 页码:365-373 , 文章类型: Article,,卷期:2010年432-Part 2]
Cell activation by stressors is characterized by a sequence of detectable phenotypic cell changes. A given stimulus, depending on its strength, induces modifications in the activity of membrane phospholipid transporte...
- Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic beta-cells
[作者:Aoyagi, K; Ohara-Imaizumi, M; Nishiwaki, C; Nakamichi, Y; Nagamatsu, S,期刊:Biochemical Journal, 页码:375-386 , 文章类型: Article,,卷期:2010年432-Part 2]
- Functional insulin receptor and its downstream effector PI3K (phosphoinositide 3-kinase) have been identified in pancreatic beta-cells, but their involvement in the regulation of insulin secretion from beta-cells remains...
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