- Stress-protective signalling of prion protein is corrupted by scrapie prions
[作者:Rambold, AS; Muller, V; Ron, U; Ben-Tal, N; Winklhofer, KF; Tatzelt, J,期刊:EMBO journal, 页码:1974-1984 , 文章类型: Article,,卷期:2008年27-14]
- Studies in transgenic mice revealed that neurodegeneration induced by scrapie prion (PrPSc) propagation is dependent on neuronal expression of the cellular prion protein PrPC. On the other hand, there is evidence that Pr...
- Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
[作者:Ikenoue, T; Inoki, K; Yang, Q; Zhou, X; Guan, KL,期刊:EMBO journal, 页码:1919-1931 , 文章类型: Article,,卷期:2008年27-14]
- Protein kinase C (PKC) is involved in a wide array of cellular processes such as cell proliferation, differentiation and apoptosis. Phosphorylation of both turn motif (TM) and hydrophobic motif (HM) are important for PKC...
- The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
[作者:Facchinetti, V; Ouyang, WM; Wei, H; Soto, N; Lazorchak, A; Gould, C; Lowry, C; Newton, AC; Mao, YX; Miao, RQ; Sessa, WC; Qin, J; Zhang, PM; Su, B; Jacinto, E,期刊:EMBO journal, 页码:1932-1943 , 文章类型: Article,,卷期:2008年27-14]
- The target of rapamycin (TOR), as part of the rapamycin-sensitive TOR complex 1 (TORC1), regulates various aspects of protein synthesis. Whether TOR functions in this process as part of TORC2 remains to be elucidated. He...
- Molecular basis for maintenance of fidelity during the CCA-adding reaction by a CCA-adding enzyme
[作者:Toh, Y; Numata, T; Watanabe, K; Takeshita, D; Nureki, O; Tomita, K,期刊:EMBO journal, 页码:1944-1952 , 文章类型: Article,,卷期:2008年27-14]
- CCA-adding enzyme builds the 3'-end CCA of tRNA without a nucleic acid template. The mechanism for the maintenance of fidelity during the CCA-adding reaction remains elusive. Here, we present almost a dozen complex struc...
- Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
[作者:Jazayeri, A; Balestrini, A; Garner, E; Haber, JE; Costanzo, V,期刊:EMBO journal, 页码:1953-1962 , 文章类型: Article,,卷期:2008年27-14]
- DNA double-strand breaks (DSBs) can be processed by the Mre11-Rad50-Nbs1 (MRN) complex, which is essential to promote ataxia telangiectasia-mutated (ATM) activation. However, the molecular mechanisms linking MRN activity...
- Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
[作者:Wu, JH; Li, W; Craddock, BP; Foreman, KW; Mulvihill, MJ; Ji, QS; Miller, WT; Hubbard, SR,期刊:EMBO journal, 页码:1985-1994 , 文章类型: Article,,卷期:2008年27-14]
- The insulin-like growth factor-1 receptor (IGF1R) is a receptor tyrosine kinase (RTK) that has a critical role in mitogenic signalling during embryogenesis and an antiapoptotic role in the survival and progression of man...
- Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II
[作者:Stieglitz, B; Bee, C; Schwarz, D; Yildiz, O; Moshnikova, A; Khokhlatchev, A; Herrmann, C,期刊:EMBO journal, 页码:1995-2005 , 文章类型: Article,,卷期:2008年27-14]
- A class of putative Ras effectors called Ras association domain family (RASSF) represents non-enzymatic adaptors that were shown to be important in tumour suppression. RASSF5, a member of this family, exists in two splic...
- Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization
[作者:Lamber, EP; Vanhille, L; Textor, LC; Kachalova, GS; Sieweke, MH; Wilmanns, M,期刊:EMBO journal, 页码:2006-2017 , 文章类型: Article,,卷期:2008年27-14]
- The function of the Ets-1 transcription factor is regulated by two regions that flank its DNA-binding domain. A previously established mechanism for auto-inhibition of monomeric Ets-1 on DNA response elements with a sing...
- Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
[作者:Bhati, M; Lee, C; Nancarrow, AL; Lee, M; Craig, VJ; Bach, I; Guss, JM; Mackay, JP; Matthews, JM,期刊:EMBO journal, 页码:2018-2029 , 文章类型: Article,,卷期:2008年27-14]
- LIM-homeodomain (LIM-HD) transcription factors form a combinatorial 'LIM code' that contributes to the specification of cell types. In the ventral spinal cord, the binary LIM homeobox protein 3 (Lhx3)/LIM domain-binding ...
- Structure of Escherichia coli tyrosine kinase Etk reveals a novel activation mechanism (vol 27, pg 1758, 2008)
[作者:Lee, DC; Zheng, JM; She, YM; Jia, ZC,期刊:EMBO journal, 页码:2030-2030 , 文章类型: Correction,,卷期:2008年27-14]
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