- Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperones
[作者:Mima, J; Hickey, CM; Xu, H; Jun, Y; Wickner, W,期刊:EMBO journal, 页码:2031-2042 , 文章类型: Article,,卷期:2008年27-15]
- The homotypic fusion of yeast vacuoles, each with 3Q- and 1R-SNARE, requires SNARE chaperones (Sec17p/Sec18p and HOPS) and regulatory lipids (sterol, diacylglycerol and phosphoinositides). Pairs of liposomes of phosphati...
- Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load
[作者:Farhan, H; Weiss, M; Tani, K; Kaufman, RJ; Hauri, HP,期刊:EMBO journal, 页码:2043-2054 , 文章类型: Article,,卷期:2008年27-15]
- The biogenesis of endoplasmic reticulum (ER) exit sites (ERES) involves the formation of phosphatidylinositol-4 phosphate (PI4) and Sec16, but it is entirely unknown how ERES adapt to variations in cargo load. Here, we s...
- Regulation of contractile vacuole formation and activity in Dictyostelium
[作者:Du, F; Edwards, K; Shen, Z; Sun, B; De Lozanne, A; Briggs, S; Firtel, RA,期刊:EMBO journal, 页码:2064-2076 , 文章类型: Article,,卷期:2008年27-15]
- The contractile vacuole (CV) system is the osmoregulatory organelle required for survival for many free-living cells under hypotonic conditions. We identified a new CV regulator, Disgorgin, a TBC-domain-containing protei...
- Extracellular Alix regulates integrin-mediated cell adhesions and extracellular matrix assembly
[作者:Pan, S; Wang, R; Zhou, X; Corvera, J; Kloc, M; Sifers, R; Gallick, GE; Lin, SH; Kuang, J,期刊:EMBO journal, 页码:2077-2090 , 文章类型: Article,,卷期:2008年27-15]
- Alix (ALG-2-interacting protein X), a cytoplasmic adaptor protein involved in endosomal sorting and actin cytoskeleton assembly, is required for the maintenance of fibroblast morphology. As Alix has sequence similarity t...
- Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation
[作者:Stachelscheid, H; Ibrahim, H; Koch, L; Schmitz, A; Tscharntke, M; Wunderlich, FT; Scott, J; Michels, C; Wickenhauser, C; Haase, I; Bruning, JC; Niessen, CM,期刊:EMBO journal, 页码:2091-2101 , 文章类型: Article,,卷期:2008年27-15]
- The lifelong self-renewal of the epidermis is driven by a progenitor cell population with high proliferative potential. To date, the upstream signals that determine this potential have remained largely elusive. Here, we ...
- Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4
[作者:Haas, G; Azevedo, J; Moissiard, G; Geldreich, A; Himber, C; Bureau, M; Fukuhara, T; Keller, M; Voinnet, O,期刊:EMBO journal, 页码:2102-2112 , 文章类型: Article,,卷期:2008年27-15]
Replication of Cauliflower mosaic virus (CaMV), a plant double-stranded DNA virus, requires the viral translational transactivator protein P6. Although P6 is known to form cytoplasmic inclusion bodies (viroplasms) so ...
- Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
[作者:Colin, E; Zala, D; Liot, G; Rangone, H; Borrell-Pages, M; Li, XJ; Saudou, F; Humbert, S,期刊:EMBO journal, 页码:2124-2134 , 文章类型: Article,,卷期:2008年27-15]
- The transport of vesicles in neurons is a highly regulated process, with vesicles moving either anterogradely or retrogradely depending on the nature of the molecular motors, kinesins and dynein, respectively, which prop...
- The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
[作者:Soulat, D; Burckstummer, T; Westermayer, S; Goncalves, A; Bauch, A; Stefanovic, A; Hantschel, O; Bennett, KL; Decker, T; Superti-Furga, G,期刊:EMBO journal, 页码:2135-2146 , 文章类型: Article,,卷期:2008年27-15]
- TANK-binding kinase 1 (TBK1) is of central importance for the induction of type-I interferon (IFN) in response to pathogens. We identified the DEAD-box helicase DDX3X as an interaction partner of TBK1. TBK1 and DDX3X act...
- Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors
[作者:Yao, Y; Harrison, CB; Freddolino, PL; Schulten, K; Mayer, ML,期刊:EMBO journal, 页码:2158-2170 , 文章类型: Article,,卷期:2008年27-15]
- NR3 subtype glutamate receptors have a unique developmental expression profile, but are the least well-characterized members of the NMDA receptor gene family, which have key roles in synaptic plasticity and brain develop...
- Crystal structures of the OmpF porin: function in a colicin translocon
[作者:Yamashita, E; Zhalnina, MV; Zakharov, SD; Sharma, O; Cramer, WA,期刊:EMBO journal, 页码:2171-2180 , 文章类型: Article,,卷期:2008年27-15]
- The OmpF porin in the Escherichia coli outer membrane (OM) is required for the cytotoxic action of group A colicins, which are proposed to insert their translocation and active domains through OmpF pores. A crystal struc...
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