- Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity
[作者：Maestre, C; Delgado-Esteban, M; Gomez-Sanchez, JC; Bolanos, JP; Almeida, A,期刊：EMBO journal, 页码：2736-2745 , 文章类型： Article，,卷期：2008年27-20]
- Anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase that destabilizes cell cycle proteins, is activated by Cdh1 in post-mitotic neurons, where it regulates axonal growth, synaptic plasticity and survival...
- ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription
[作者：Masuda, HP; Cabral, LM; De Veylder, L; Tanurdzic, M; Engler, JD; Geelen, D; Inze, D; Martienssen, RA; Ferreira, PCG; Hemerly, AS,期刊：EMBO journal, 页码：2746-2756 , 文章类型： Article，,卷期：2008年27-20]
- In multicellular organisms, organogenesis requires a tight control of the balance between cell division and cell differentiation. Distinct signalling pathways that connect both cellular processes with developmental cues ...
- The 'P-usher', a novel protein transporter involved in fimbrial assembly and TpsA secretion
[作者：Ruer, S; Ball, G; Filloux, A; de Bentzmann, S,期刊：EMBO journal, 页码：2669-2680 , 文章类型： Article，,卷期：2008年27-20]
- We identified a new bacterial transporter, the Pseudomonas aeruginosa CupB3 protein, which is an outer membrane usher involved in pili assembly. In CupB3, the usher domain has fused during evolution with a POTRA (polypep...
- G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription
[作者：Tachibana, M; Matsumura, Y; Fukuda, M; Kimura, H; Shinkai, Y,期刊：EMBO journal, 页码：2681-2690 , 文章类型： Article，,卷期：2008年27-20]
- Methylation of DNA and lysine 9 of histone H3 (H3K9) are well-conserved epigenetic marks for transcriptional silencing. Although H3K9 methylation directs DNA methylation in filamentous fungi and plants, this pathway has ...
- DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity
[作者：Dong, KB; Maksakova, IA; Mohn, F; Leung, D; Appanah, R; Lee, S; Yang, HW; Lam, LL; Mager, DL; Schubeler, D; Tachibana, M; Shinkai, Y; Lorincz, MC,期刊：EMBO journal, 页码：2691-2701 , 文章类型： Article，,卷期：2008年27-20]
- Histone H3K9 methylation is required for DNA methylation and silencing of repetitive elements in plants and filamentous fungi. In mammalian cells however, deletion of the H3K9 histone methyltransferases (HMTases) Suv39h1...
- Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions
[作者：Shorter, J; Lindquist, S,期刊：EMBO journal, 页码：2712-2724 , 文章类型： Article，,卷期：2008年27-20]
- Self-templating amyloid forms of Sup35 constitute the yeast prion [PSI+]. How the protein-remodelling factor, Hsp104, collaborates with other chaperones to regulate [PSI+] inheritance remains poorly delineated. Here, we ...
- Curing of the [URE3] prion by Btn2p, a Batten disease-related protein
[作者：Kryndushkin, DS; Shewmaker, F; Wickner, RB,期刊：EMBO journal, 页码：2725-2735 , 文章类型： Article，,卷期：2008年27-20]
- [URE3] is a prion (infectious protein), a self-propagating amyloid form of Ure2p, a regulator of yeast nitrogen catabolism. We find that overproduction of Btn2p, or its homologue Ypr158 (Cur1p), cures [URE3]. Btn2p is re...
- An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies
[作者：Bosnakovski, D; Xu, ZH; Gang, EJ; Galindo, CL; Liu, MJ; Simsek, T; Garner, HR; Agha-Mohammadi, S; Tassin, A; Coppee, F; Belayew, A; Perlingeiro, RR; Kyba, M,期刊：EMBO journal, 页码：2766-2779 , 文章类型： Article，,卷期：2008年27-20]
- Facioscapulohumeral muscular dystrophy (FSHD) is caused by an unusual deletion with neomorphic activity. This deletion derepresses genes in cis; however which candidate gene causes the FSHD phenotype, and through what me...
- Structural insights into mechanism and specificity of O-GlcNAc transferase
[作者：Clarke, AJ; Hurtado-Guerrero, R; Pathak, S; Schuttelkopf, AW; Borodkin, V; Shepherd, SM; Ibrahim, AFM; van Aalten, DMF,期刊：EMBO journal, 页码：2780-2788 , 文章类型： Article，,卷期：2008年27-20]
- Post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. O-GlcN...
- Structural and functional coupling of Hsp90-and Sgt1-centred multi-protein complexes
[作者：Zhang, MH; Boter, M; Li, KY; Kadota, Y; Panaretou, B; Prodromou, C; Shirasu, K; Pearl, LH,期刊：EMBO journal, 页码：2789-2798 , 文章类型： Article，,卷期：2008年27-20]
- Sgt1 is an adaptor protein implicated in a variety of processes, including formation of the kinetochore complex in yeast, and regulation of innate immunity systems in plants and animals. Sgt1 has been found to associate ...
- Turning of the receptor-binding domains opens up the murine leukaemia virus Env for membrane fusion
[作者：Wu, SR; Sjoberg, M; Wallin, M; Lindqvist, B; Ekstrom, M; Hebert, H; Koeck, PJB; Garoff, H,期刊：EMBO journal, 页码：2799-2808 , 文章类型： Article，,卷期：2008年27-20]
- The activity of the membrane fusion protein Env of Moloney mouse leukaemia virus is controlled by isomerization of the disulphide that couples its transmembrane (TM) and surface (SU) subunits. We have arrested Env activa...
- IKK alpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer
[作者：Descargues, P; Sil, AK; Karin, M,期刊：EMBO journal, 页码：2639-2647 , 文章类型： Review，,卷期：2008年27-20]
- I kappa B kinase alpha (IKK alpha), one of the two catalytic subunits of the IKK complex involved in nuclear factor kappa B (NF-kappa B) activation, also functions as a molecular switch that controls epidermal differenti...
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