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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Determination of bacterial rod shape by a novel cytoskeletal membrane protein [作者：Shiomi, D; Sakai, M; Niki, H,期刊：EMBO journal, 页码：3081-3091 , 文章类型： Article，,卷期：2008年27-23] Cell shape is critical for growth, and some genes are involved in bacterial cell morphogenesis. Here, we report a novel gene, rodZ, required for the determination of rod shape in Escherichia coli. Cells lacking rodZ no l... G(q)-coupled receptors as mechanosensors mediating myogenic vasoconstriction [作者：Schnitzler, MMY; Storch, U; Meibers, S; Nurwakagari, P; Breit, A; Essin, K; Gollasch, M; Gudermann, T,期刊：EMBO journal, 页码：3092-3103 , 文章类型： Article，,卷期：2008年27-23] Despite the central physiological function of the myogenic response, the underlying signalling pathways and the identity of mechanosensors in vascular smooth muscle (VSM) are still elusive. In contrast to present thinkin... P2Y(6) receptor-G alpha(12/13) signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis [作者：Nishida, M; Sato, Y; Uemura, A; Narita, Y; Tozaki-Saitoh, H; Nakaya, M; Ide, T; Suzuki, K; Inoue, K; Nagao, T; Kurose, H,期刊：EMBO journal, 页码：3104-3115 , 文章类型： Article，,卷期：2008年27-23] Cardiac fibrosis, characterized by excessive deposition of extracellular matrix proteins, is one of the causes of heart failure, and it contributes to the impairment of cardiac function. Fibrosis of various tissues, incl... Silencing and transcriptional properties of the imprinted Airn ncRNA are independent of the endogenous promoter [作者：Stricker, SH; Steenpass, L; Pauler, FM; Santoro, F; Latos, PA; Huang, R; Koerner, MV; Sloane, MA; Warczok, KE; Barlow, DP,期刊：EMBO journal, 页码：3116-3128 , 文章类型： Article，,卷期：2008年27-23] The Airn macro ncRNA is the master regulator of imprinted expression in the Igf2r imprinted gene cluster where it silences three flanking genes in cis. Airn transcription shows unusual features normally viewed as promote... A protein that replaces the entire cellular eIF4F complex [作者：Mir, MA; Panganiban, AT,期刊：EMBO journal, 页码：3129-3139 , 文章类型： Article，,卷期：2008年27-23] The eIF4F cap-binding complex mediates the initiation of cellular mRNA translation. eIF4F is composed of eIF4E, which binds to the mRNA cap, eIF4G, which indirectly links the mRNA cap with the 43S pre-initiation complex,... Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair [作者：Chou, WC; Wang, HC; Wong, FH; Ding, SL; Wu, PE; Shieh, SY; Shen, CY,期刊：EMBO journal, 页码：3140-3150 , 文章类型： Article，,卷期：2008年27-23] The DNA damage response (DDR) has an essential function in maintaining genomic stability. Ataxia telangiectasiamutated (ATM)-checkpoint kinase 2 (Chk2) and ATM- and Rad3-related (ATR)-Chk1, triggered, respectively, by DN... Cytokinesis of neuroepithelial cells can divide their basal process before anaphase [作者：Kosodo, Y; Toida, K; Dubreuil, V; Alexandre, P; Schenk, J; Kiyokage, E; Attardo, A; Mora-Bermudez, F; Arii, T; Clarke, JDW; Huttner, WB,期刊：EMBO journal, 页码：3151-3163 , 文章类型： Article，,卷期：2008年27-23] Neuroepithelial (NE) cells, the primary stem and progenitor cells of the vertebrate central nervous system, are highly polarized and elongated. They retain a basal process extending to the basal lamina, while undergoing ... Structural determinants of Kv beta 1.3-induced channel inactivation: a hairpin modulated by PIP2 [作者：Decher, N; Gonzalez, T; Streit, AK; Sachse, FB; Renigunta, V; Soom, M; Heinemann, SH; Daut, J; Sanguinetti, MC,期刊：EMBO journal, 页码：3164-3174 , 文章类型： Article，,卷期：2008年27-23] Inactivation of voltage-gated Kv1 channels can be altered by Kv beta subunits, which block the ion-conducting pore to induce a rapid ('N-type') inactivation. Here, we investigate the mechanisms and structural basis of Kv... Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure [作者：Komander, D; Garg, R; Wan, PTC; Ridley, AJ; Barford, D,期刊：EMBO journal, 页码：3175-3185 , 文章类型： Article，,卷期：2008年27-23] The ROCK-I serine/threonine protein kinase mediates the effects of RhoA to promote the formation of actin stress fibres and integrin-based focal adhesions. ROCK-I phosphorylates the unconventional G-protein RhoE on multi... Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase [作者：Mieczkowski, C; Iavarone, AT; Alber, T,期刊：EMBO journal, 页码：3186-3197 , 文章类型： Article，,卷期：2008年27-23] Many Ser/Thr protein kinases are activated by autophosphorylation, but the mechanism of this process has not been defined. We determined the crystal structure of a mutant of the Ser/Thr kinase domain (KD) of the mycobact... Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL [作者：Mouilleron, S; Guettler, S; Langer, CA; Treisman, R; McDonald, NQ,期刊：EMBO journal, 页码：3198-3208 , 文章类型： Article，,卷期：2008年27-23] Serum response factor transcriptional activity is controlled through interactions with regulatory cofactors such as the coactivator MAL/MRTF-A (myocardin-related transcription factor A). MAL is itself regulated in vivo b... Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein [作者：Luo, DH; Xu, T; Watson, RP; Scherer-Becker, D; Sampath, A; Jahnke, W; Yeong, SS; Wang, CH; Lim, SP; Strongin, A; Vasudevan, SG; Lescar, J,期刊：EMBO journal, 页码：3209-3219 , 文章类型： Article，,卷期：2008年27-23] Together with the NS5 polymerase, the NS3 helicase has a pivotal function in flavivirus RNA replication and constitutes an important drug target. We captured the dengue virus NS3 helicase at several stages along the cata...