- NOD1 Activators Link Innate Immunity to Insulin Resistance
[作者：Schertzer, JD; Tamrakar, AK; Magalhaes, JG; Pereira, S; Bilan, PJ; Fullerton, MD; Liu, Z; Steinberg, GR; Giacca, A; Philpott, DJ; Klip, A,期刊：Diabetes, 页码：2206-2215 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-Insulin resistance associates with chronic inflammation, and participatory elements of the immune system are emerging. We hypothesized that bacterial elements acting on distinct intracellular pattern recognitio...
- Oxidative Phosphorylation Flexibility in the Liver of Mice Resistant to High-Fat Diet-Induced Hepatic Steatosis
[作者：Poussin, C; Ibberson, M; Hall, D; Ding, J; Soto, J; Abel, ED; Thorens, B,期刊：Diabetes, 页码：2216-2224 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-To identify metabolic pathways that may underlie susceptibility or resistance to high-fat diet-induced hepatic steatosis. RESEARCH DESIGN AND METHODS-We performed comparative transcriptomic analysis of the live...
- Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats
[作者：Torres, TP; Fujimoto, Y; Donahue, EP; Printz, RL; Houseknecht, KL; Treadway, JL; Shiota, M,期刊：Diabetes, 页码：2225-2233 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-Examine whether normalizing net hepatic glycogenesis restores endogenous glucose production and hepatic glucose phosphorylation in response to diabetic levels of plasma glucose and insulin in Zucker diabetic fa...
- Cyanidin-3-O-beta-Glucoside and Protocatechuic Acid Exert Insulin-Like Effects by Upregulating PPAR gamma Activity in Human Omental Adipocytes
[作者：Scazzocchio, B; Vari, R; Filesi, C; D'Archivio, M; Santangelo, C; Giovannini, C; Iacovelli, A; Silecchia, G; Volti, GL; Galvano, F; Masella, R,期刊：Diabetes, 页码：2234-2244 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-Insulin resistance (IR) represents an independent risk factor for metabolic, cardiovascular, and neoplastic disorders. Preventing/attenuating IR is a major objective to be reached to preserve population health....
- Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-delta
[作者：Cabou, C; Vachoux, C; Campistron, G; Drucker, DJ; Burcelin, R,期刊：Diabetes, 页码：2245-2256 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-Glucagon-like peptide 1 (GLP-1) is a gut-brain hormone that regulates food intake, energy metabolism, and cardiovascular functions. In the brain, through a currently unknown molecular mechanism, it simultaneous...
- Increased VLDL-Triglyceride Secretion Precedes Impaired Control of Endogenous Glucose Production in Obese, Normoglycemic Men
[作者：Sorensen, LP; Sondergaard, E; Nellemann, B; Christiansen, JS; Gormsen, LC; Nielsen, S,期刊：Diabetes, 页码：2257-2264 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-To assess basal and insulin-mediated VLDL-triglyceride (TG) kinetics and the relationship between VLDL-TG secretion and hepatic insulin resistance assessed by endogenous glucose production (EGP) in obese and le...
- Therapeutic Impact of Leptin on Diabetes, Diabetic Complications, and Longevity in Insulin-Deficient Diabetic Mice
[作者：Naito, M; Fujikura, J; Ebihara, K; Miyanaga, F; Yokoi, H; Kusakabe, T; Yamamoto, Y; Son, C; Mukoyama, M; Hosoda, K; Nakao, K,期刊：Diabetes, 页码：2265-2273 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-The aim of the current study was to evaluate the long-term effects of leptin on glucose metabolism, diabetes complications, and life span in an insulin-dependent diabetes model, the Akita mouse. RESEARCH DESIGN...
- Continued Postnatal Administration of Resveratrol Prevents Diet-Induced Metabolic Syndrome in Rat Offspring Born Growth Restricted
[作者：Dolinsky, VW; Rueda-Clausen, CF; Morton, JS; Davidge, ST; Dyck, JRB,期刊：Diabetes, 页码：2274-2284 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-A prenatal hypoxic insult leading to intrauterine growth restriction (IUGR) increases the susceptibility to develop metabolic syndrome (MetS) later in life. Since resveratrol (Resv), the polyphenol produced by ...
- Apolipoprotein E4 Exaggerates Diabetic Dyslipidemia and Atherosclerosis in Mice Lacking the LDL Receptor
[作者：Johnson, LA; Arbones-Mainar, JM; Fox, RG; Pendse, AA; Altenburg, MK; Kim, HS; Maeda, N,期刊：Diabetes, 页码：2285-2294 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-We investigated the differential roles of apolipoprotein E (apoE) isoforms in modulating diabetic dyslipidemia- a potential cause of the increased cardiovascular disease risk of patients with diabetes. RESEARCH...
- Physical Activity Attenuates the Effect of Low Birth Weight on Insulin Resistance in Adolescents Findings From Two Observational Studies
[作者：Ortega, FB; Ruiz, JR; Hurtig-Wennlof, A; Meirhaeghe, A; Gonzalez-Gross, M; Moreno, LA; Molnar, D; Kafatos, A; Gottrand, F; Widhalm, K; Labayen, I; Sjostrom, M,期刊：Diabetes, 页码：2295-2299 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-To examine whether physical activity influences the association between birth weight and insulin resistance in adolescents. RESEARCH DESIGN AND METHODS-The study comprised adolescents who participated in two cr...
- Free Fatty Acid Storage in Human Visceral and Subcutaneous Adipose Tissue Role of Adipocyte Proteins
[作者：Ali, AH; Koutsari, C; Mundi, M; Stegall, MD; Heimbach, JK; Taler, SJ; Nygren, J; Thorell, A; Bogachus, LD; Turcotte, LP; Bernlohr, D; Jensen, MD,期刊：Diabetes, 页码：2300-2307 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-Because direct adipose tissue free fatty acid (FFA) storage may contribute to body fat distribution, we measured FFA (palmitate) storage rates and fatty acid (FA) storage enzymes/proteins in omental and abdomin...
- Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet beta-Cells
[作者：Dezaki, K; Damdindorj, B; Sone, H; Dyachok, O; Tengholm, A; Gylfe, E; Kurashina, T; Yoshida, M; Kakei, M; Yada, T,期刊：Diabetes, 页码：2315-2324 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-Ghrelin reportedly restricts insulin release in islet beta-cells via the G alpha(i2) subtype of G-proteins and thereby regulates glucose homeostasis. This study explored whether ghrelin regulates cAMP signaling...
- Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4(+) T Cells
[作者：Debug, T; Baker, RL; Reisdorph, N; Reisdorph, R; Powell, RL; Armstrong, M; Barbour, G; Bradley, B; Haskins, K,期刊：Diabetes, 页码：2325-2330 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-To investigate autoantigens in beta-cells, we have used a panel of pathogenic T-cell clones that were derived from the NOD mouse. Our particular focus in this study was on the identification of the target antig...
- Immunosuppressive Effects of Streptozotocin-Induced Diabetes Result in Absolute Lymphopenia and a Relative Increase of T Regulatory Cells
[作者：Muller, YD; Golshayan, D; Ehirchiou, D; Wyss, JC; Giovannoni, L; Meier, R; Serre-Beinier, V; Yung, GP; Morel, P; Buhler, LH; Seebach, JD,期刊：Diabetes, 页码：2331-2340 , 文章类型： Article，,卷期：2011年60-9]
- OBJECTIVE-Streptozotocin (STZ) is the most widely used diabetogenic agent in animal models of islet transplantation. However, the immunomodifying effects of STZ and the ensuing hyperglycemia on lymphocyte subsets, partic...
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