- Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material
[作者：Westerlund, M; Belin, AC; Anvret, A; Hakansson, A; Nissbrandt, H; Lind, C; Sydow, O; Olson, L; Galter, D,期刊：FASEB Journal, 页码：3509-3514 , 文章类型： Article，,卷期：2008年22-10]
- Alterations of brain and plasma a-synuclein levels and SNCA gene variability have been implicated in the pathogenesis of Parkinson's disease (PD). We therefore measured a-synuclein protein levels in postmortem PD and con...
- Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases
[作者：Troeberg, L; Fushimi, K; Khokha, R; Emonard, H; Ghosh, P; Nagase, H,期刊：FASEB Journal, 页码：3515-3524 , 文章类型： Article，,卷期：2008年22-10]
- Degradation of the cartilage proteoglycan aggrecan is a key early event in the development of osteoarthritis. Adamalysin with thrombospondin motifs (ADAMTS) A and ADAMTS-5 are considered to be the main enzymes responsibl...
- VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
[作者：Fan, XJ; Krieg, S; Kuo, CJ; Wiegand, SJ; Rabinovitch, M; Druzin, ML; Brenner, RM; Giudice, LC; Nayak, NR,期刊：FASEB Journal, 页码：3571-3580 , 文章类型： Article，,卷期：2008年22-10]
- Despite extensive literature on vascular endothelial growth factor (VEGF) expression and regulation by steroid hormones, the lack of clear understanding of the mechanisms of angiogenesis in the endometrium is a major lim...
- Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes
[作者：Chen, JQ; Hui, ST; Couto, FM; Mungrue, IN; Davis, DB; Attie, AD; Lusis, AJ; Davis, RA; Shalev, A,期刊：FASEB Journal, 页码：3581-3594 , 文章类型： Article，,卷期：2008年22-10]
- Pancreatic beta-cell loss through apoptosis represents a key factor in the pathogenesis of diabetes; however, no effective approaches to block this process and preserve endogenous beta-cell mass are currently available. ...
- Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design
[作者：Ng, AKL; Zhang, HM; Tan, KM; Li, ZL; Liu, JH; Chan, PKS; Li, SM; Chan, WY; Au, SWN; Joachimiak, A; Walz, T; Wang, JH; Shaw, PC,期刊：FASEB Journal, 页码：3638-3647 , 文章类型： Article，,卷期：2008年22-10]
- The threat of a pandemic outbreak of influenza virus A H5N1 has become a major concern worldwide. The nucleoprotein (NP) of the virus binds the RNA genome and acts as a key adaptor between the virus and the host cell. It...
- Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I-K,I-slow1 and I-to,I-f
[作者：Roepke, TK; Kontogeorgis, A; Ovanez, C; Xu, XH; Young, JB; Purtell, K; Goldstein, PA; Christini, DJ; Peters, NS; Akar, FG; Gutstein, DE; Lerner, DJ; Abbott, GW,期刊：FASEB Journal, 页码：3648-3660 , 文章类型： Article，,卷期：2008年22-10]
- Mutations in human KCNE2, which encodes the MiRP1 potassium channel ancillary subunit, associate with long QT syndrome (LQTS), a defect in ventricular repolarization. The precise cardiac role of MiRP1 remains controversi...
- LPA(1) is essential for lymphatic vessel development in zebrafish
[作者：Lee, SJ; Chan, TH; Chen, TC; Liao, BK; Hwang, PP; Lee, H,期刊：FASEB Journal, 页码：3706-3715 , 文章类型： Article，,卷期：2008年22-10]
- Lysophosphatidic acid (LPA) has long been implicated in regulating vascular development via endothelial cell-expressed G protein-coupled receptors. However, because of a lack of notable vascular defects reported in LPA r...
- A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
[作者：Raucci, A; Cugusi, S; Antonelli, A; Barabino, SM; Monti, L; Bierhaus, A; Reiss, K; Saftig, P; Bianchi, ME,期刊：FASEB Journal, 页码：3716-3727 , 文章类型： Article，,卷期：2008年22-10]
- The receptor for advanced glycation endproducts (RAGE) mediates responses to cell danger and stress. When bound by its many ligands (which include advanced glycation endproducts, certain members of the S100/calgranulin f...
- Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance
[作者：Einstein, FH; Fishman, S; Bauman, J; Thompson, RF; Huffman, DM; Atzmon, G; Barzilai, N; Muzumdar, RH,期刊：FASEB Journal, 页码：3450-3457 , 文章类型： Article，,卷期：2008年22-10]
- Calorie restriction improves life span whereas nutrient excess leads to obesity and unfavorable metabolic consequences, supporting the role for a cellular "nutrient sensor" in aging. Hexosamine biosynthetic pathway (HBP)...
- Vascularized tissue-engineered chambers promote survival and function of transplanted islets and improve glycemic control (vol 20, pg 565, 2006)
[作者：Knight, KR; Uda, Y; Findlay, MW; Brown, DL; Cronin, KJ; Jamieson, E; Tai, T; Keramidaris, E; Penington, AJ; Rophael, J; Harrison, LC; Morrison, WA,期刊：FASEB Journal, 页码：3747-3747 , 文章类型： Correction，,卷期：2008年22-10]
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- Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy
[作者：Sveinbjornsson, B; Rasmuson, A; Baryawno, N; Wan, M; Pettersen, I; Ponthan, F; Orrego, A; Haeggstrom, JZ; Johnsen, JI; Kogner, P,期刊：FASEB Journal, 页码：3525-3536 , 文章类型： Article，,卷期：2008年22-10]
- The metabolism of arachidonic acid by the cyclooxygenase (COX) or lipoxygenase (LO) pathways generates eicosanoids that have been implicated in the pathogenesis of a variety of human diseases, including cancer. In this s...
- mu-opioid receptor activation in live cells
[作者：Vukojevic, V; Ming, Y; D'Addario, C; Hansen, M; Langel, U; Schulz, R; Johansson, B; Rigler, R; Terenius, L,期刊：FASEB Journal, 页码：3537-3548 , 文章类型： Article，,卷期：2008年22-10]
- Interaction of the mu-opioid receptor (MOP) with selected ligands was investigated in live cells using advanced imaging by confocal laser scanning microscopy integrated with fluorescence correlation spectroscopy and fluo...
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