个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共33条记录   At what age do biomedical scientists do their best work? [作者：Falagas, ME; Ierodiakonou, V; Alexiou, VG,期刊：FASEB Journal, 页码：4067-4070 , 文章类型： Article，,卷期：2008年22-12] Several human characteristics that influence scientific research performance, including set goals, mental and physical abilities, education, and experience, may vary considerably during the life cycle of scientists. We s... Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans [作者：Jakubowski, H; Boers, GHJ; Strauss, KA,期刊：FASEB Journal, 页码：4071-4076 , 文章类型： Article，,卷期：2008年22-12] Severely elevated plasma homocysteine (Hcy) levels observed in genetic disorders of Hcy metabolism are associated with pathologies in multiple organs and lead to premature death due to vascular complications. In addition... Nucleosome-releasing factor: a new role for factor VII-activating protease (FSAP) [作者：Zeerleder, S; Zwart, B; Velthuis, HT; Stephan, F; Manoe, R; Rensink, I; Aarden, LA,期刊：FASEB Journal, 页码：4077-4084 , 文章类型： Article，,卷期：2008年22-12] Plasma proteins such as early complement components and IgM are involved in the removal of late apoptotic or secondary necrotic (sn) cells. We have recently described how a plasma protease that could be inhibited by the ... Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3 ' untranslated region: a role for microRNA23b [作者：Wu, QF; Law, PY; Wei, LN; Loh, HH,期刊：FASEB Journal, 页码：4085-4095 , 文章类型： Article，,卷期：2008年22-12] Expression of the mu opioid receptor (MOR1) protein is regulated temporally and spatially. Although transcription of its gene has been studied extensively, regulation of MOR1 protein production at the level of translatio... Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX? [作者：Jadin, L; Wu, XL; Ding, H; Frost, GI; Onclinx, C; Triggs-Raine, B; Flamion, B,期刊：FASEB Journal, 页码：4316-4326 , 文章类型： Article，,卷期：2008年22-12] The metabolism of hyaluronan (HA) relies on HA synthases and hyaluronidases, among which hyaluronidase-1 (HYAL1) and -2 (HYAL2) have been proposed as key actors. Congenital HYAL1 deficiency leads to mucopolysaccharidosis... Increased blood pressure in mice lacking cytochrome P450 2J5 [作者：Athirakul, K; Bradbury, JA; Graves, JP; DeGraff, LM; Ma, JX; Zhao, Y; Couse, JF; Quigley, R; Harder, DR; Zhao, XY; Imig, JD; Pedersen, TL; Newman, JW; Hammock, BD; Conley, AJ; Korach, KS; Coffman, TM; Zeldin, DC,期刊：FASEB Journal, 页码：4096-4108 , 文章类型： Article，,卷期：2008年22-12] The cytochrome P450 (CYP) enzymes participate in a wide range of biochemical functions, including metabolism of arachidonic acid and steroid hormones. Mouse CYP2J5 is abundant in the kidney where its products, the cis-ep... The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity [作者：Yuki, K; Astrof, NS; Bracken, C; Yoo, R; Silkworth, W; Soriano, SG; Shimaoka, M,期刊：FASEB Journal, 页码：4109-4116 , 文章类型： Article，,卷期：2008年22-12] The molecular and structural basis of anesthetic interactions with conformations and functionalities of cell surface receptors remains to be elucidated. We have demonstrated that the widely used volatile anesthetic isofl... The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters [作者：van Roermund, CWT; Visser, WF; Ijlst, L; van Cruchten, A; Boek, M; Kulik, W; Waterham, HR; Wanders, RJA,期刊：FASEB Journal, 页码：4201-4208 , 文章类型： Article，,卷期：2008年22-12] Peroxisomes play a major role in human cellular lipid metabolism, including the beta-oxidation of fatty acids. The most frequent peroxisomal disorder is X-linked adrenoleukodystrophy (X-ALD), which is caused by mutations... Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase [作者：Albiston, AL; Morton, CJ; Ng, HL; Pham, V; Yeatman, HR; Ye, S; Fernando, RN; De Bundel, D; Ascher, DB; Mendelsohn, FAO; Parker, MW; Chai, SY,期刊：FASEB Journal, 页码：4209-4217 , 文章类型： Article，,卷期：2008年22-12] Approximately one-quarter of people over the age of 65 are estimated to suffer some form of cognitive impairment, underscoring the need for effective cognitive-enhancing agents. Insulin-regulated aminopeptidase (IRAP) is... Inhibition of a eukaryotic initiation factor (eIF2B delta/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans [作者：Tohyama, D; Yamaguchi, A; Yamashita, T,期刊：FASEB Journal, 页码：4327-4337 , 文章类型： Article，,卷期：2008年22-12] The critical role of protein synthesis in regulating lifespan has been evidenced. This study shows that adult-onset RNAi inactivation of eukaryotic initiation factor 2B delta (eIF2B delta/F11A3.2), a subunit of eIF2B, ex... Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells [作者：Atanasov, AG; Leiser, D; Roesselet, C; Noti, M; Corazza, N; Schoonjans, K; Brunner, T,期刊：FASEB Journal, 页码：4117-4125 , 文章类型： Article，,卷期：2008年22-12] Glucocorticoids are anti-inflammatory steroids with important applications in the treatment of inflammatory diseases. Endogenous glucocorticoids are mainly produced by the adrenal glands, although there is increasing evi... MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy [作者：Wang, Q; Wang, YL; Minto, AW; Wang, JH; Shi, Q; Li, XM; Quigg, RJ,期刊：FASEB Journal, 页码：4126-4135 , 文章类型： Article，,卷期：2008年22-12] Intrinsic glomerular cells in a diabetic milieu have transcriptional activation of genes that influence the development of diabetic nephropathy. The cellular repertoire of microRNAs can regulate translation of these expr... Apelin/APJ signaling system: a potential link between adipose tissue and endothelial angiogenic processes [作者：Kunduzova, O; Alet, N; Delesque-Touchard, N; Millet, L; Castan-Laurell, I; Muller, C; Dray, C; Schaeffer, P; Herault, JP; Savi, P; Bono, F; Valet, P,期刊：FASEB Journal, 页码：4146-4153 , 文章类型： Article，,卷期：2008年22-12] Adipose tissue is an active endocrine organ that produces a variety of secretory factors involved in the initiation of angiogenic processes. The bioactive peptide apelin is the endogenous ligand of the G protein-coupled ... A promising cancer gene therapy agent based on the matrix protein of vesicular stomatitis virus [作者：Zhao, JM; Wen, YJ; Li, Q; Wang, YS; Wu, HB; Xu, JR; Chen, XC; Wu, Y; Fan, LY; Yang, HS; Liu, T; Ding, ZY; Du, XB; Diao, P; Li, J; Wu, HB; Kan, B; Lei, S; Deng, HX; Mao, YQ; Zhao, X; Wei, YQ,期刊：FASEB Journal, 页码：4272-4280 , 文章类型： Article，,卷期：2008年22-12] The matrix (M) protein of vesicular stomatitis virus (VSV) plays a key role in inducing cell apoptosis during infection. To investigate whether M protein-mediated apoptosis could be used in cancer therapy, its cDNA was a... NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure [作者：Flockhart, RJ; Diffey, BL; Farr, PM; Lloyd, J; Reynolds, NJ,期刊：FASEB Journal, 页码：4218-4227 , 文章类型： Article，,卷期：2008年22-12] The nuclear factor of activated T cells (NFAT) transcription factors are regulated by calcium/calcineurin signals and play important roles in T cells, muscle, bone, and neural tissue. NFAT is expressed in the epidermis, ... Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion [作者：Leoni, G; Patel, HB; Sampaio, ALF; Gavins, FNE; Murray, JF; Grieco, P; Getting, SJ; Perretti, M,期刊：FASEB Journal, 页码：4228-4238 , 文章类型： Article，,卷期：2008年22-12] The existence of anti-inflammatory circuits centered on melanocortin receptors (MCRs) has been supported by the inhibitory properties displayed by melanocortin peptides in models of inflammation and tissue injury. Here w...