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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共51条记录   Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca(2+)-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet beta-Cells [作者：Demozay, D; Tsunekawa, S; Briaud, I; Shah, R; Rhodes, CJ,期刊：Diabetes, 页码：2892-2902 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-Insulin receptor substrate-2 (IRS-2) plays an essential role in pancreatic islet beta-cells by promoting growth and survival. IRS-2 turnover is rapid in primary beta-cells, but its expression is highly regulate... Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes [作者：Ferraro, A; Socci, C; Stabilini, A; Valle, A; Monti, P; Piemonti, L; Nano, R; Olek, S; Maffi, P; Scavini, M; Secchi, A; Staudacher, C; Bonifacio, E; Battaglia, M,期刊：Diabetes, 页码：2903-2913 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-Autoimmune diseases, including type 1 diabetes, are thought to have a Th17-cell bias and/or a T-regulatory cell (Treg) defect. Understanding whether this is a hallmark of patients with type 1 diabetes is a cruc... Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell-Directed Type 1 Diabetes Therapies [作者：Serreze, DV; Chapman, HD; Niens, M; Dunn, R; Kehry, MR; Driver, JP; Haller, M; Wasserfal, C; Atkinson, MA,期刊：Diabetes, 页码：2914-2921 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-Consistent with studies in NOD mice, early clinical trials addressing whether depletion of B cells by the Rituximab CD20-specific antibody provides an effective means for type 1 diabetes reversal have produced ... Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice [作者：Oeser, JK; Parekh, VV; Wang, YD; Jegadeesh, NK; Sarkar, SA; Wong, R; Lee, CE; Pound, LD; Hutton, JC; Van Kaer, L; O'Brien, RM,期刊：Diabetes, 页码：2922-2927 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), now known as G6PC2, is a major target of autoreactive T cells implicated in the pathogenesis of type 1 diabetes in both mice and hu... Targeted Inhibition of Calpain Reduces Myocardial Hypertrophy and Fibrosis in Mouse Models of Type 1 Diabetes [作者：Li, Y; Ma, J; Zhu, HQ; Singh, M; Hill, D; Greer, PA; Arnold, JM; Abel, ED; Peng, TQ,期刊：Diabetes, 页码：2985-2994 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-Recently we have shown that calpain-1 activation contributes to cardiomyocyte apoptosis induced by hyperglycemia. This study was undertaken to investigate whether targeted disruption of calpain would reduce myo... Intervention With an Erythropoietin-Derived Peptide Protects Against Neuroglial and Vascular Degeneration During Diabetic Retinopathy [作者：McVicar, CM; Hamilton, R; Colhoun, LM; Gardiner, TA; Brines, M; Cerami, A; Stitt, AW,期刊：Diabetes, 页码：2995-3005 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-Erythropoietin (EPO) may be protective for early stage diabetic retinopathy, although there are concerns that it could exacerbate retinal angiogenesis and thrombosis. A peptide based on the EPO helix-B domain (... Prospectively Determined Impact of Type 1 Diabetes on Brain Volume During Development [作者：Perantie, DC; Koller, JM; Weaver, PM; Lugar, HM; Black, KJ; White, NH; Hershey, T,期刊：Diabetes, 页码：3006-3014 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE The impact of type 1 diabetes mellitus (T1DM) on the developing central nervous system is not well understood. Cross-sectional, retrospective studies suggest that exposure to glycemic extremes during developmen... Arginase-2 Mediates Diabetic Renal Injury [作者：Morris, SM; Gao, T; Cooper, TK; Kepka-Lenhart, D; Awad, AS,期刊：Diabetes, 页码：3015-3022 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-To determine 1) whether renal arginase activity or expression is increased in diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN). RESEARCH DESIGN AND METHODS-The impact of... Abrogation of MMP-9 Gene Protects Against the Development of Retinopathy in Diabetic Mice by Preventing Mitochondrial Damage [作者：Kowluru, RA; Mohammad, G; dos Santos, JM; Zhong, Q,期刊：Diabetes, 页码：3023-3033 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-In the development of diabetic retinopathy, mitochondrial dysfunction is considered to play an important role in the apoptosis of retinal capillary cells. Diabetes activates matrix metalloproteinase-9 (MMP-9) i... A Novel Cellular Defect in Diabetes Membrane Repair Failure [作者：Howard, AC; McNeil, AK; Xiong, F; Xiong, WC; McNeil, PL,期刊：Diabetes, 页码：3034-3043 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-Skeletal muscle myopathy is a common diabetes complication. One possible cause of myopathy is myocyte failure to repair contraction-generated plasma membrane injuries. Here, we test the hypothesis that diabetes... APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice [作者：Wang, Y; Cheng, KKY; Lam, KSL; Wu, DH; Wang, Y; Huang, Y; Vanhoutte, PM; Sweeney, G; Li, YM; Xu, AM,期刊：Diabetes, 页码：3044-3054 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-Insulin stimulates both nitric oxide (NO)-dependent vasodilation and endothelin-1 (ET-1)-dependent vasoconstriction. However, the cellular mechanisms that control the dual vascular effects of insulin remain unc... Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy [作者：Zheng, HT; Whitman, SA; Wu, W; Wondrak, GT; Wong, PK; Fang, DY; Zhang, DD,期刊：Diabetes, 页码：3055-3066 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function during the course of streptozotocin (STZ)-induced diabe... C-peptide Response and HLA Genotypes in Subjects With Recent-Onset Type 1 Diabetes After Immunotherapy With DiaPep277 An Exploratory Study [作者：Buzzetti, R; Cernea, S; Petrone, A; Capizzi, M; Spoletini, M; Zampetti, S; Guglielmi, C; Venditti, C; Pozzilli, P,期刊：Diabetes, 页码：3067-3072 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-To investigate whether lower risk HLA class II genotypes would influence the efficacy of DiaPep277 therapy in protecting beta-cell function evaluated by C-peptide secretion in recent-onset type I diabetic subje... Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients With Type 1 Diabetes [作者：Syreeni, A; El-Osta, A; Forsblom, C; Sandholm, N; Parkkonen, M; Tarnow, L; Parving, HH; McKnight, AJ; Maxwell, AP; Cooper, ME; Groop, PH,期刊：Diabetes, 页码：3073-3080 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-Hyperglycemia plays a pivotal role in the development and progression of vascular complications, which are the major sources of morbidity and mortality in diabetes. Furthermore, these vascular complications oft... FUT2 Nonsecretor Status Links Type 1 Diabetes Susceptibility and Resistance to Infection [作者：Smyth, DJ; Cooper, JD; Howson, JMM; Clarke, P; Downes, K; Mistry, T; Stevens, H; Walker, NM; Todd, JA,期刊：Diabetes, 页码：3081-3084 , 文章类型： Article，,卷期：2011年60-11] OBJECTIVE-FUT2 encodes the alpha(1,2) fucosyltransferase that determines blood group secretor status. Homozygotes (A/A) for the common nonsense mutation rs601338A>G (W143X) are non-secretors and are unable to express his... Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the beta-cell sulfonylurea receptor SUR1 (vol 60, pg 1797, 2011) [作者：MacMullen, CM; Zhou, Q; Snider, KE; Tewson, PH; Becker, SA; Aziz, AR; Ganguly, A; Shyng, SL; Stanley, CA,期刊：Diabetes, 页码：3097-3097 , 文章类型： Correction，,卷期：2011年60-11]