- Multimodality Imaging of beta-Cells in Mouse Models of Type 1 and 2 Diabetes
[作者：Yong, J; Rasooly, J; Dang, H; Lu, YX; Middleton, B; Zhang, ZS; Hon, L; Namavari, M; Stout, DB; Atkinson, MA; Tian, JD; Gambhir, SS; Kaufman, DL,期刊：Diabetes, 页码：1383-1392 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE-beta-Cells that express an imaging reporter have provided powerful tools for studying beta-cell development, islet transplantation, and beta-cell autoimmunity. To further expedite diabetes research, we generate...
- Drosophila Insulin Pathway Mutants Affect Visual Physiology and Brain Function Besides Growth, Lipid, and Carbohydrate Metabolism
[作者：Murillo-Maldonado, JM; Sanchez-Chavez, G; Salgado, LM; Salceda, R; Riesgo-Escovar, JR,期刊：Diabetes, 页码：1632-1636 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE Type 2 diabetes is the most common form of diabetes worldwide. Some of its complications, such as retinopathy and neuropathy, are long-term and protracted, with an unclear etiology. Given this problem, genetic ...
- FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
[作者：Hertel, JK; Johansson, S; Sonestedt, E; Jonsson, A; Lie, RT; Platou, CGP; Nilsson, PM; Rukh, G; Midthjell, K; Hveem, K; Melander, O; Groop, L; Lyssenko, V; Molven, A; Orho-Melander, M; Njolstad, PR,期刊：Diabetes, 页码：1637-1644 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE-FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO) influences BMI across adu...
- Generation of Stable Pluripotent Stem Cells From NOD Mouse Tail-Tip Fibroblasts
[作者：Liu, J; Ashton, MP; Sumer, H; O'Bryan, MK; Brodnicki, TC; Verma, PJ,期刊：Diabetes, 页码：1393-1398 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE-The NOD mouse strain has been widely used to investigate the pathology and genetic susceptibility for type 1 diabetes. Induced pluripotent stem cells (iPSCs) derived from this unique mouse strain would enable n...
- O-G1cNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver
[作者：Guinez, C; Filhoulaud, G; Rayah-Benhamed, F; Mannier, S; Dubuquoy, C; Dentin, R; Moldes, M; Burnol, AF; Yang, XY; Lefebvre, T; Girard, J; Postic, C,期刊：Diabetes, 页码：1399-1413 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE Carbohydrate-responsive element-binding protein (ChREBP) is a key transcription factor that mediates the effects of glucose on glycolytic and lipogenic genes in the liver. We have previously reported that liver...
- Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling
[作者：Denroche, HC; Levi, J; Wideman, RD; Sequeira, RM; Huynh, FK; Covey, SD; Kieffer, TJ,期刊：Diabetes, 页码：1414-1423 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE Leptin therapy has been found to reverse hyperglycemia and prevent mortality in several rodent models of type I diabetes. Yet the mechanism of leptin-mediated reversal of hyperglycemia has not been fully define...
- Central Leptin Signaling Is Required to Normalize Myocardial Fatty Acid Oxidation Rates in Caloric-Restricted ob/ob Mice
[作者：Sloan, C; Tuinei, J; Nemetz, K; Frandsen, J; Soto, J; Wride, N; Sempokuya, T; Alegria, L; Bugger, H; Abel, ED,期刊：Diabetes, 页码：1424-1434 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE ob/ob and db/db mice manifest myocardial hypertrophy, insulin resistance, altered substrate utilization, mitochondrial dysfunction, and lipid accumulation. This study was designed to determine the contribution ...
- Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis
[作者：Luo, XL; Zhang, YX; Ruan, XB; Jiang, XM; Zhu, L; Wang, X; Ding, QR; Liu, WZ; Pan, Y; Wang, ZZ; Chen, Y,期刊：Diabetes, 页码：1435-1445 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE-Most animals experience fasting-feeding cycles throughout their lives. It is well known that the liver plays a central role in regulating glycogen metabolism. However, how hepatic glycogenesis is coordinated wi...
- Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance
[作者：Mulvihill, EE; Assini, JM; Lee, JK; Allister, EM; Sutherland, BG; Koppes, JB; Sawyez, CG; Edwards, JY; Telford, DE; Charbonneau, A; St-Pierre, P; Marette, A; Huff, MW,期刊：Diabetes, 页码：1446-1457 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE-Increased plasma concentrations of apolipoprotein B100 often present in patients with insulin resistance and confer increased risk for the development of atherosclerosis. Naturally occurring polyphenolic compou...
- Pigment Epithelium-Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase
[作者：Borg, ML; Andrews, ZB; Duh, EJ; Zechner, R; Meikle, PJ; Watt, MJ,期刊：Diabetes, 页码：1458-1466 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE-Pigment epithelium-derived factor (PEDF) is an adipocyte-secreted factor involved in the development of insulin resistance in obesity. Previous studies have identified PEDF as a regulator of triacylglycerol met...
- Effect of Acute Hypoglycemia on Human Cerebral Glucose Metabolism Measured by C-13 Magnetic Resonance Spectroscopy
[作者：van de Ven, KCC; de Galan, BE; van der Graaf, M; Shestov, AA; Henry, PG; Tack, CJJ; Heerschap, A,期刊：Diabetes, 页码：1467-1473 , 文章类型： Article，,卷期：2011年60-5]
- OBJECT WE-To investigate the effect of acute insulin-induced hypoglycemia on cerebral glucose metabolism in healthy humans, measured by C-13 magnetic resonance spectroscopy (MRS). RESEARCH DESIGN AND METHODS-Hyperinsulin...
- Recombinant Human Leptin Treatment Does Not Improve Insulin Action in Obese Subjects With Type 2 Diabetes
[作者：Mittendorfer, B; Horowitz, JF; DePaoli, AM; McCamish, MA; Patterson, BW; Klein, S,期刊：Diabetes, 页码：1474-1477 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE-Leptin therapy improves insulin sensitivity in people with leptin deficiency, but it is not known whether it improves insulin action in people who are not leptin deficient. The purpose of the current study was ...
- Improved Insulin Sensitivity by GLUT12 Overexpression in Mice
[作者：Purcell, SH; Aerni-Flessner, LB; Willcockson, AR; Diggs-Andrews, KA; Fisher, SJ; Moley, KH,期刊：Diabetes, 页码：1478-1482 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE Evidence suggests that insulin-sensitive glucose transporters (GLUTs) other than GLUT4 may exist. To investigate whether GLUT12 may represent another insulin-sensitive GLUT, transgenic (TG) mice that overexpres...
- Metformin Inhibits Nuclear Receptor TR4-Mediated Hepatic Stearoyl-CoA Desaturase 1 Gene Expression With Altered Insulin Sensitivity
[作者：Kim, E; Liu, NC; Yu, IC; Lin, HY; Lee, YF; Sparks, JD; Chen, LM; Chang, C,期刊：Diabetes, 页码：1493-1503 , 文章类型： Article，,卷期：2011年60-5]
- OBJECTIVE-TR4 is a nuclear receptor without clear pathophysiological roles. We investigated the roles of hepatic TR4 in the regulation of lipogenesis and insulin sensitivity in vivo and in vitro. RESEARCH DESIGN AND METH...
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